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Home Fluorides 1186688-54-9
1186688-54-9,MFCD20261405
Catalog No.:AA00HEMR

1186688-54-9 | 4,4-Difluoropiperidin-3-ol hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
97%
in stock  
$299.00   $209.00
- +
250mg
97%
in stock  
$553.00   $387.00
- +
1g
97%
in stock  
$1,537.00   $1,076.00
- +
5g
97%
in stock  
$5,664.00   $3,965.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HEMR
Chemical Name:
4,4-Difluoropiperidin-3-ol hydrochloride
CAS Number:
1186688-54-9
Molecular Formula:
C5H10ClF2NO
Molecular Weight:
173.5888
MDL Number:
MFCD20261405
SMILES:
OC1CNCCC1(F)F.Cl
Properties
Computed Properties
 
Complexity:
107  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:MERCK&COINC-EP2264026,2010,A1Locationinpatent:Page/Pagecolumn46

1186688-54-9   
(S)-2-cyclopropyl-10-((2,5-dichloropyrimidin-4-yl)amino)-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-1,4oxazepino2,3-cquinolin-6(7H)-one 
 
10-((5-chloro-2-((S)-4,4-difluoro-3-hydroxypiperidin-1-yl)-pyrimidin-4-yl)amino)-2-cyclopropyl-3,3-difluoro-7-methyl-1,2,3,4-tetrahydro-1,4oxazepino2,3-cquinolin-6(7H)-one 

[1]Huckvale,Rosemary;Harnden,AliceC.;Cheung,Kwai-MingJ.;Pierrat,OlivierA.;Talbot,Rachel;Box,GaryM.;Henley,AlanT.;DeHavenBrandon,AlexisK.;Hallsworth,AlbertE.;Bright,MichaelD.;Akpinar,HafizeAysin;Miller,DanielS.J.;Tarantino,Dalia;Gowan,Sharon;Hayes,Angela;Gunnell,EmmaA.;Brennan,Alfie;Davis,OwenA.;Johnson,LouiseD.;DeKlerk,Selby;McAndrew,Craig;LeBihan,Yann-Vaï;Meniconi,Mirco;Burke,Rosemary;Kirkin,Vladimir;VanMontfort,RobL.M.;Raynaud,FlorenceI.;Rossanese,OliviaW.;Bellenie,BenjaminR.;Hoelder,Swen[JournalofMedicinalChemistry,2022,vol.65,#12,p.8191-8207]

1186688-54-9   
5-((2,5-dichloropyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzodimidazol-2-one 
 
5-((5-chloro-2-(4,4-difluoro-3-hydroxypiperidin-1-yl)pyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzodimidazol-2-one 

[1]Huckvale,Rosemary;Harnden,AliceC.;Cheung,Kwai-MingJ.;Pierrat,OlivierA.;Talbot,Rachel;Box,GaryM.;Henley,AlanT.;DeHavenBrandon,AlexisK.;Hallsworth,AlbertE.;Bright,MichaelD.;Akpinar,HafizeAysin;Miller,DanielS.J.;Tarantino,Dalia;Gowan,Sharon;Hayes,Angela;Gunnell,EmmaA.;Brennan,Alfie;Davis,OwenA.;Johnson,LouiseD.;DeKlerk,Selby;McAndrew,Craig;LeBihan,Yann-Vaï;Meniconi,Mirco;Burke,Rosemary;Kirkin,Vladimir;VanMontfort,RobL.M.;Raynaud,FlorenceI.;Rossanese,OliviaW.;Bellenie,BenjaminR.;Hoelder,Swen[JournalofMedicinalChemistry,2022,vol.65,#12,p.8191-8207]

Literature
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Tags:1186688-54-9 Molecular Formula|1186688-54-9 MDL|1186688-54-9 SMILES|1186688-54-9 4,4-Difluoropiperidin-3-ol hydrochloride