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1188-38-1,MFCD00047874
Catalog No.:AA00383G

1188-38-1 | N-Carbamyl-l-glutamic acid

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250mg
97%
in stock  
$7.00   $5.00
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1g
97%
in stock  
$21.00   $15.00
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5g
97%
in stock  
$25.00   $18.00
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10g
97%
in stock  
$42.00   $29.00
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25g
97%
in stock  
$65.00   $46.00
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100g
97%
in stock  
$146.00   $103.00
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500g
97%
in stock  
$458.00   $321.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00383G
Chemical Name:
N-Carbamyl-l-glutamic acid
CAS Number:
1188-38-1
Molecular Formula:
C6H10N2O5
Molecular Weight:
190.1540
MDL Number:
MFCD00047874
SMILES:
OC(=O)CC[C@@H](C(=O)O)NC(=O)N
Properties
Computed Properties
 
Complexity:
227  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
-2.4  

Literature

Title: Effects of dietary L-arginine or N-carbamylglutamate supplementation during late gestation of sows on the miR-15b/16, miR-221/222, VEGFA and eNOS expression in umbilical vein.

Journal: Amino acids 20120601

Title: A novel biochemically salvageable animal model of hyperammonemia devoid of N-acetylglutamate synthase.

Journal: Molecular genetics and metabolism 20120601

Title: Effect of dietary arginine and N-carbamoylglutamate supplementation on reproduction and gene expression of eNOS, VEGFA and PlGF1 in placenta in late pregnancy of sows.

Journal: Animal reproduction science 20120601

Title: N-carbamylglutamate enhances pregnancy outcome in rats through activation of the PI3K/PKB/mTOR signaling pathway.

Journal: PloS one 20120101

Title: N-carbamylglutamate enhancement of ureagenesis leads to discovery of a novel deleterious mutation in a newly defined enhancer of the NAGS gene and to effective therapy.

Journal: Human mutation 20111001

Title: The HepaRG cell line is suitable for bioartificial liver application.

Journal: The international journal of biochemistry & cell biology 20111001

Title: Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase.

Journal: The Journal of biological chemistry 20110624

Title: N-carbamylglutamate treatment for acute neonatal hyperammonemia in isovaleric acidemia.

Journal: European journal of pediatrics 20110601

Title: New developments in the treatment of hyperammonemia: emerging use of carglumic acid.

Journal: International journal of general medicine 20110101

Title: MR spectroscopy-based brain metabolite profiling in propionic acidaemia: metabolic changes in the basal ganglia during acute decompensation and effect of liver transplantation.

Journal: Orphanet journal of rare diseases 20110101

Title: Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency.

Journal: Therapeutics and clinical risk management 20110101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20101201

Title: Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet.

Journal: Amino acids 20100801

Title: N-carbamylglutamate augments ureagenesis and reduces ammonia and glutamine in propionic acidemia.

Journal: Pediatrics 20100701

Title: Carglumic acid approved to treat genetic hyperammonemia.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100501

Title: Outpatient treatment of propionic acidemia-associated hyperammonemia with N-carbamoyl-L-glutamate in an infant.

Journal: Clinical therapeutics 20100401

Title: Favourable long-term outcome after immediate treatment of neonatal hyperammonemia due to N-acetylglutamate synthase deficiency.

Journal: European journal of pediatrics 20100201

Title: Biochemical efficacy of N-carbamylglutamate in neonatal severe hyperammonaemia due to propionic acidaemia.

Journal: European journal of pediatrics 20100101

Title: N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria.

Journal: Neonatology 20100101

Title: N-acetylglutamate synthase: structure, function and defects.

Journal: Molecular genetics and metabolism 20100101

Title: Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis.

Journal: Molecular genetics and metabolism 20091201

Title: [N-carbamyl glutamate treatment in hyperammoniemia decompensated propionic acidaemia].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20091201

Title: The first use of N-carbamylglutamate in a patient with decompensated maple syrup urine disease.

Journal: Metabolic brain disease 20090901

Title: Pricing of orphan drugs.

Journal: Lancet (London, England) 20090207

Title: Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes.

Journal: Genome biology 20090101

Title: N-carbamylglutamate for neonatal hyperammonaemia in propionic acidaemia.

Journal: Journal of inherited metabolic disease 20081201

Title: N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers.

Journal: Pediatric research 20080801

Title: [A newborn infant with hyperventilation].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080626

Title: Carglumic acid: a second look. Confirmed progress in a rare urea cycle disorder.

Journal: Prescrire international 20080401

Title: Carglumic acid: an additional therapy in the treatment of organic acidurias with hyperammonemia?

Journal: Orphanet journal of rare diseases 20080101

Title: Mutations and polymorphisms in the human N-acetylglutamate synthase (NAGS) gene.

Journal: Human mutation 20070801

Title: A trial with N-carbamylglutamate may not detect all patients with NAGS deficiency and neonatal onset.

Journal: Journal of inherited metabolic disease 20070601

Title: Metabolic fates of ammonia-N in ruminal epithelial and duodenal mucosal cells isolated from growing sheep.

Journal: Journal of dairy science 20051101

Title: Neonatal hyperammonemia: the N-carbamoyl-L-glutamic acid test.

Journal: The Journal of pediatrics 20050801

Title: Misleading diagnosis of partial N-acetylglutamate synthase deficiency based on enzyme measurement corrected by mutation analysis.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20050101

Title: N-carbamylglutamate protects patients with decompensated propionic aciduria from hyperammonaemia.

Journal: Journal of inherited metabolic disease 20050101

Title: Restoration of ureagenesis in N-acetylglutamate synthase deficiency by N-carbamylglutamate.

Journal: The Journal of pediatrics 20041001

Title: Urea synthesis by ruminal epithelial and duodenal mucosal cells from growing sheep.

Journal: Journal of dairy science 20040601

Title: Mammalian N-acetylglutamate synthase.

Journal: Molecular genetics and metabolism 20040401

Title: Carglumic acid: new preparation. An advance in rare urea cycle disorders.

Journal: Prescrire international 20040201

Title: Hyperammonaemia as a cause of psychosis in an adolescent.

Journal: European journal of pediatrics 20031101

Title: N-carbamylglutamate enhances ammonia detoxification in a patient with decompensated methylmalonic aciduria.

Journal: Molecular genetics and metabolism 20030801

Title: N-acetylglutamate synthase deficiency and the treatment of hyperammonemic encephalopathy.

Journal: Annals of neurology 20021201

Title: Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.

Journal: Journal of hepatology 20011201

Title: Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients.

Journal: Pediatric research 20010901

Title: [Orphan drugs and metabolic disorders].

Journal: Revista de neurologia 20010801

Title: Chen CT, et al. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015 Nov 15;5(12):3560-9.

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Tags:1188-38-1 Molecular Formula|1188-38-1 MDL|1188-38-1 SMILES|1188-38-1 N-Carbamyl-l-glutamic acid