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Home Other Building Blocks 1188910-76-0
1188910-76-0,MFCD22124524
Catalog No.:AA0039PW

1188910-76-0 | CEP-32496

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
5mg
98%
in stock  
$8.00   $6.00
- +
10mg
98%
in stock  
$11.00   $8.00
- +
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Technical Information
Catalog Number:
AA0039PW
Chemical Name:
CEP-32496
CAS Number:
1188910-76-0
Molecular Formula:
C24H22F3N5O5
Molecular Weight:
517.4572
MDL Number:
MFCD22124524
SMILES:
COc1cc2c(ncnc2cc1OC)Oc1cccc(c1)NC(=O)Nc1noc(c1)C(C(F)(F)F)(C)C
Properties
Computed Properties
 
Complexity:
776  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
5  

Literature

Title: Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

Journal: Journal of medicinal chemistry 20120209

Title: Rowbottom MW, et al. Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

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Tags:1188910-76-0 Molecular Formula|1188910-76-0 MDL|1188910-76-0 SMILES|1188910-76-0 CEP-32496