Home Amines 1194044-20-6
1194044-20-6,MFCD18074525
Catalog No.:AA000IN9

1194044-20-6 | (4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine

Pack Size
Purity
Availability
Price(USD)
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1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$276.00   $193.00
- +
10mg
≥98%
in stock  
$488.00   $341.00
- +
100mg
98%
in stock  
$660.00   $462.00
- +
250mg
98%
in stock  
$1,268.00   $888.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000IN9
Chemical Name:
(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
CAS Number:
1194044-20-6
Molecular Formula:
C15H14F2N4S
Molecular Weight:
320.3603
MDL Number:
MFCD18074525
SMILES:
NC1=N[C@](CCS1)(C)c1cc(c2cncnc2)c(cc1F)F
Properties
Computed Properties
 
Complexity:
430  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.1  

Literature

Title: Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111116

Title: May PC, et al. Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor. J Neurosci. 2011 Nov 16;31(46):16507-16516.

Title: Zhang X, et al. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9734-9.

Title: Ghosh AK, et al. Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer's Disease. ChemMedChem. 2015 Sep;10(9):1463-6

Title: Filser S, et al. Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions. Biol Psychiatry. 2015 Apr 15;77(8):729-39.

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SDS
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Tags:1194044-20-6 Molecular Formula|1194044-20-6 MDL|1194044-20-6 SMILES|1194044-20-6 (4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine