119431-25-3,MFCD00866651
Catalog No.:AA000INS

119431-25-3 | 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-

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1mg
99+%
in stock  
$29.00   $20.00
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5mg
99+%
in stock  
$65.00   $46.00
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10mg
99+%
in stock  
$96.00   $68.00
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25mg
99+%
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$164.00   $115.00
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50mg
99+%
in stock  
$213.00   $149.00
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100mg
99+%
in stock  
$319.00   $223.00
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250mg
99+%
in stock  
$478.00   $335.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000INS
Chemical Name:
1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-
CAS Number:
119431-25-3
Molecular Formula:
C20H23ClFNO
Molecular Weight:
347.8541
MDL Number:
MFCD00866651
SMILES:
Fc1ccc(cc1)CC1CCN(CC1)CC(c1ccc(cc1)Cl)O
Properties
Computed Properties
 
Complexity:
359  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.5  

Downstream Synthesis Route

[1]Pabel,Joerg;Hoefner,Georg;Wanner,KlausTh.[BioorganicandMedicinalChemistryLetters,2000,vol.10,#12,p.1377-1380]

[1]Pabel,Joerg;Hoefner,Georg;Wanner,KlausTh.[BioorganicandMedicinalChemistryLetters,2000,vol.10,#12,p.1377-1380]

[1]Pabel,Joerg;Hoefner,Georg;Wanner,KlausTh.[BioorganicandMedicinalChemistryLetters,2000,vol.10,#12,p.1377-1380]

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.

Journal: PloS one 20120101

Title: A complex interaction between glycine/NMDA receptors and serotonergic/noradrenergic antidepressants in the forced swim test in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20111101

Title: The effects of a single memantine treatment on behavioral alterations associated with binge alcohol exposure in neonatal rats.

Journal: Neurotoxicology and teratology 20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182.

Journal: Enzyme research 20110101

Title: Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.

Journal: Bioorganic & medicinal chemistry 20101115

Title: Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors.

Journal: Journal of pharmaceutical and biomedical analysis 20101102

Title: The site specific demethylation in the 5'-regulatory area of NMDA receptor 2B subunit gene associated with CIE-induced up-regulation of transcription.

Journal: PloS one 20100101

Title: Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease.

Journal: Molecular neurodegeneration 20100101

Title: A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full.

Journal: Trials 20100101

Title: A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

Journal: Analytical biochemistry 20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Pharmacology and therapeutic potential of sigma(1) receptor ligands.

Journal: Current neuropharmacology 20081201

Title: Hypoxia-ischemia and retinal ganglion cell damage.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20081201

Title: Alcohol related changes in regulation of NMDA receptor functions.

Journal: Current neuropharmacology 20080301

Title: Pigment epithelium-derived factor protects retinal ganglion cells.

Journal: BMC neuroscience 20070101

Title: Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia.

Journal: Current medicinal chemistry 20070101

Title: The sequential analysis of repeated binary responses: a score test for the case of three time points.

Journal: Statistics in medicine 20060715

Title: Adaptation of USP types II and IV controlled release assays for sparingly soluble compounds by direct eluent HPLC analysis.

Journal: Pharmaceutical development and technology 20060201

Title: NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.

Journal: Current drug targets. CNS and neurological disorders 20050401

Title: Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits.

Journal: Psychopharmacology 20040901

Title: Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk.

Journal: British journal of pharmacology 20040901

Title: Glutamate-dependent regulation of cholinergic phenotype in hypothalamic neurons.

Journal: Neuroreport 20031219

Title: Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Journal: The Lancet. Neurology 20021001

Title: Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations.

Journal: Neurobiology of learning and memory 20020901

Title: Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: An MCASE approach to the search of a cure for Parkinson's Disease.

Journal: BMC pharmacology 20020101

Title: NR2B selective NMDA receptor antagonists.

Journal: Current pharmaceutical design 20020101

Title: Glutamate AMPA receptor antagonist treatment for ischaemic stroke.

Journal: Current medical research and opinion 20020101

Title: NMDA antagonists produce site-selective impairment of accuracy in a delayed nonmatch-to-sample task in rats.

Journal: Neuropharmacology 20011201

Title: The NMDA receptor complex: a promising target for novel antiepileptic strategies.

Journal: Current medicinal chemistry 20010901

Title: NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent.

Journal: Behavioural pharmacology 20010401

Title: Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex.

Journal: Polish journal of pharmacology 19930101

Title: Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.

Title: Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143(1):152-8.

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SDS
Related Products of 119431-25-3
Tags:119431-25-3 Molecular Formula|119431-25-3 MDL|119431-25-3 SMILES|119431-25-3 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-
Catalog No.: AA000INS
119431-25-3,MFCD00866651
119431-25-3 | 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-
Pack Size: 1mg
Purity: 99+%
in stock
$29.00 $20.00
Pack Size: 5mg
Purity: 99+%
in stock
$65.00 $46.00
Pack Size: 10mg
Purity: 99+%
in stock
$96.00 $68.00
Pack Size: 25mg
Purity: 99+%
in stock
$164.00 $115.00
Pack Size: 50mg
Purity: 99+%
in stock
$213.00 $149.00
Pack Size: 100mg
Purity: 99+%
in stock
$319.00 $223.00
Pack Size: 250mg
Purity: 99+%
in stock
$478.00 $335.00
Quantity
- +
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Technical Information
Catalog Number: AA000INS
Chemical Name: 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-
CAS Number: 119431-25-3
Molecular Formula: C20H23ClFNO
Molecular Weight: 347.8541
MDL Number: MFCD00866651
SMILES: Fc1ccc(cc1)CC1CCN(CC1)CC(c1ccc(cc1)Cl)O
Properties
Complexity: 359  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.5  
Downstream Synthesis Route
291773-74-5    119431-25-3 

[1]Pabel,Joerg;Hoefner,Georg;Wanner,KlausTh.[BioorganicandMedicinalChemistryLetters,2000,vol.10,#12,p.1377-1380]

92822-03-2    119431-25-3 

[1]Pabel,Joerg;Hoefner,Georg;Wanner,KlausTh.[BioorganicandMedicinalChemistryLetters,2000,vol.10,#12,p.1377-1380]

536-38-9    119431-25-3 

[1]Pabel,Joerg;Hoefner,Georg;Wanner,KlausTh.[BioorganicandMedicinalChemistryLetters,2000,vol.10,#12,p.1377-1380]

Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.

Journal: PloS one20120101

Title: A complex interaction between glycine/NMDA receptors and serotonergic/noradrenergic antidepressants in the forced swim test in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20111101

Title: The effects of a single memantine treatment on behavioral alterations associated with binge alcohol exposure in neonatal rats.

Journal: Neurotoxicology and teratology20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences20110101

Title: Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182.

Journal: Enzyme research20110101

Title: Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.

Journal: Bioorganic & medicinal chemistry20101115

Title: Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors.

Journal: Journal of pharmaceutical and biomedical analysis20101102

Title: The site specific demethylation in the 5'-regulatory area of NMDA receptor 2B subunit gene associated with CIE-induced up-regulation of transcription.

Journal: PloS one20100101

Title: Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease.

Journal: Molecular neurodegeneration20100101

Title: A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full.

Journal: Trials20100101

Title: A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.

Journal: Analytical biochemistry20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Pharmacology and therapeutic potential of sigma(1) receptor ligands.

Journal: Current neuropharmacology20081201

Title: Hypoxia-ischemia and retinal ganglion cell damage.

Journal: Clinical ophthalmology (Auckland, N.Z.)20081201

Title: Alcohol related changes in regulation of NMDA receptor functions.

Journal: Current neuropharmacology20080301

Title: Pigment epithelium-derived factor protects retinal ganglion cells.

Journal: BMC neuroscience20070101

Title: Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia.

Journal: Current medicinal chemistry20070101

Title: The sequential analysis of repeated binary responses: a score test for the case of three time points.

Journal: Statistics in medicine20060715

Title: Adaptation of USP types II and IV controlled release assays for sparingly soluble compounds by direct eluent HPLC analysis.

Journal: Pharmaceutical development and technology20060201

Title: NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.

Journal: Current drug targets. CNS and neurological disorders20050401

Title: Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits.

Journal: Psychopharmacology20040901

Title: Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk.

Journal: British journal of pharmacology20040901

Title: Glutamate-dependent regulation of cholinergic phenotype in hypothalamic neurons.

Journal: Neuroreport20031219

Title: Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

Journal: The Lancet. Neurology20021001

Title: Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations.

Journal: Neurobiology of learning and memory20020901

Title: Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20020801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: An MCASE approach to the search of a cure for Parkinson's Disease.

Journal: BMC pharmacology20020101

Title: NR2B selective NMDA receptor antagonists.

Journal: Current pharmaceutical design20020101

Title: Glutamate AMPA receptor antagonist treatment for ischaemic stroke.

Journal: Current medical research and opinion20020101

Title: NMDA antagonists produce site-selective impairment of accuracy in a delayed nonmatch-to-sample task in rats.

Journal: Neuropharmacology20011201

Title: The NMDA receptor complex: a promising target for novel antiepileptic strategies.

Journal: Current medicinal chemistry20010901

Title: NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent.

Journal: Behavioural pharmacology20010401

Title: Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex.

Journal: Polish journal of pharmacology19930101

Title: Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.

Title: Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143(1):152-8.

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