Home Other Building Blocks 1195-08-0
1195-08-0,MFCD00192185
Catalog No.:AA000IT5

1195-08-0 | 5-Formyluracil

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100mg
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$12.00   $8.00
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250mg
95%
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$16.00   $11.00
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1g
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$19.00   $14.00
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5g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000IT5
Chemical Name:
5-Formyluracil
CAS Number:
1195-08-0
Molecular Formula:
C5H4N2O3
Molecular Weight:
140.0969
MDL Number:
MFCD00192185
SMILES:
O=Cc1c[nH]c(=O)[nH]c1=O
Properties
Properties
 
Form:
Solid  
MP:
>300 °C  
Stability:
Air Sensitive  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
231  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
-1  

Literature

Title: Profiling cytosine oxidation in DNA by LC-MS/MS.

Journal: Chemical research in toxicology 20120917

Title: A blueprint for a mutationist theory of replicative strand asymmetries formation.

Journal: Current genomics 20120301

Title: The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44.

Journal: PloS one 20120101

Title: Structural and functional properties of CiNTH, an endonuclease III homologue of the ascidian Ciona intestinalis: critical role of N-terminal region.

Journal: Genes & genetic systems 20120101

Title: Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes.

Journal: PloS one 20110101

Title: Solid-phase molecular recognition of cytosine based on proton-transfer reaction. Part II. supramolecular architecture in the cocrystals of cytosine and its 5-Fluoroderivative with 5-Nitrouracil.

Journal: Chemistry Central journal 20110101

Title: Selective recognition of uracil and its derivatives using a DNA repair enzyme structural mimic.

Journal: The Journal of organic chemistry 20100115

Title: Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions.

Journal: Journal of nucleic acids 20100101

Title: Early Steps in the DNA Base Excision Repair Pathway of a Fission Yeast Schizosaccharomyces pombe.

Journal: Journal of nucleic acids 20100101

Title: Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine.

Journal: Journal of nucleic acids 20100101

Title: Insights into the structures of DNA damaged by hydroxyl radical: crystal structures of DNA duplexes containing 5-formyluracil.

Journal: Journal of nucleic acids 20100101

Title: Thymine hydroperoxide as a potential source of singlet molecular oxygen in DNA.

Journal: Free radical biology & medicine 20090815

Title: Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1.

Journal: International journal of radiation biology 20090501

Title: Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin.

Journal: Bioinorganic chemistry and applications 20090101

Title: An unusual syn conformation of 5-formyluracil stabilized by supramolecular interactions.

Journal: Acta crystallographica. Section C, Crystal structure communications 20071101

Title: Recombinant Schizosaccharomyces pombe Nth1 protein exhibits DNA glycosylase activities for 8-oxo-7,8-dihydroguanine and thymine residues oxidized in the methyl group.

Journal: Journal of radiation research 20070901

Title: Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil, with standard DNA bases at the BSSE-free DFT and MP2 theory levels.

Journal: Organic & biomolecular chemistry 20070521

Title: The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.

Journal: FEMS microbiology letters 20070501

Title: A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.

Journal: British journal of cancer 20070226

Title: Synthesis of DNA duplexes containing complexes of 5-modified pyrimidine bases and metal ions.

Journal: Nucleic acids symposium series (2004) 20070101

Title: Voltammetric determination of gamma radiation-induced DNA damage.

Journal: Analytical biochemistry 20060801

Title: A new protein superfamily includes two novel 3-methyladenine DNA glycosylases from Bacillus cereus, AlkC and AlkD.

Journal: Molecular microbiology 20060301

Title: Recognition of oxidized thymine base on the single-stranded DNA by replication protein A.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: New Dihydro OO'Bis(Salicylidene) 2,2' Aminobenzothiazolyl Borate Complexes: Kinetic and Voltammetric Studies of Dimethyltin Copper Complex with Guanine, Adenine, and Calf Thymus DNA.

Journal: Bioinorganic chemistry and applications 20060101

Title: Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes.

Journal: Bioinorganic chemistry and applications 20060101

Title: Stable, specific, and reversible base pairing via Schiff base.

Journal: Journal of the American Chemical Society 20051130

Title: Enhancement of the in vitro transcription by T7 RNA polymerase of short DNA templates containing oxidative thymine lesions.

Journal: Comptes rendus biologies 20050901

Title: Repair of oxidative damage of thymine by HeLa whole-cell extracts: simultaneous analysis using a microsupport and comparison with traditional PAGE analysis.

Journal: Biochimie 20050201

Title: DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.

Journal: DNA repair 20050102

Title: Schiff base-mediated base pairing.

Journal: Nucleic acids symposium series (2004) 20050101

Title: 5-Formyluracil-induced perturbations of DNA function.

Journal: Biochemistry 20040518

Title: Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.

Journal: Radiation research 20040401

Title: Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases.

Journal: Biochemistry 20040316

Title: Radiation-induced DNA damage: formation, measurement, and biochemical features.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20040101

Title: Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase.

Journal: Respiratory research 20040101

Title: The transcription factor, NFI/CTF plays a positive regulatory role in expression of the hSMUG1 gene.

Journal: DNA repair 20031209

Title: Mammalian 5-formyluracil-DNA glycosylase. 1. Identification and characterization of a novel activity that releases 5-formyluracil from DNA.

Journal: Biochemistry 20030506

Title: Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.

Journal: Biochemistry 20030506

Title: Ntg1 and Ntg2 proteins as 5-formyluracil-DNA glycosylases/AP lyases in Saccharomyces cerevisiae.

Journal: International journal of radiation biology 20030501

Title: Cu(II) complexes with heterocyclic substituted thiosemicarbazones: the case of 5-formyluracil. Synthesis, characterization, x-ray structures, DNA interaction studies, and biological activity.

Journal: Inorganic chemistry 20030324

Title: Repair of the mutagenic DNA oxidation product, 5-formyluracil.

Journal: DNA repair 20030203

Title: Identification and characterization of mammalian 5-formyluracil-DNA glycosylase.

Journal: Nucleic acids research. Supplement (2001) 20030101

Title: Fragmentation of deprotonated ions of oligodeoxynucleotides carrying a 5-formyluracil or 2-aminoimidazolone.

Journal: Journal of the American Society for Mass Spectrometry 20021001

Title: Water mediated Dickerson-Drew-type crystal of DNA dodecamer containing 2'-deoxy-5-formyluridine.

Journal: Biophysical chemistry 20020328

Title: Induction of T --> G and T --> A transversions by 5-formyluracil in mammalian cells.

Journal: Mutation research 20020115

Title: Kinetic analysis of nucleotides incorporated opposite oxidized thymine bases on template DNA.

Journal: Nucleic acids research. Supplement (2001) 20020101

Title: Cellular effects of 5-formyluracil in DNA.

Journal: Mutation research 20010712

Title: Oxidation of thymine to 5-formyluracil in DNA promotes misincorporation of dGMP and subsequent elongation of a mismatched primer terminus by DNA polymerase.

Journal: The Journal of biological chemistry 20010511

Title: Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.

Journal: Mutation research 20010509

Title: Role of the Escherichia coli and human DNA glycosylases that remove 5-formyluracil from DNA in the prevention of mutations.

Journal: Journal of radiation research 20010301

Title: 5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism.

Journal: Toxicology letters 20010203

Title: Crystallization and preliminary X-ray analysis of a DNA dodecamer containing 2'-deoxy-5-formyluridine; what is the role of magnesium cation in crystallization of Dickerson-type DNA dodecamers?

Journal: Acta crystallographica. Section D, Biological crystallography 20010201

Title: Synthesis, characterisation, X-ray structure and biological activity of three new 5-formyluracil thiosemicarbazone complexes.

Journal: Journal of inorganic biochemistry 20010115

Title: Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli.

Journal: International journal of radiation biology 20010101

Title: Binding activity of replication protein A to single-stranded DNA containing oxidized pyrimidine base.

Journal: Nucleic acids research. Supplement (2001) 20010101

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