+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
119509-24-9,MFCD01664873
Catalog No.:AA000IUH

119509-24-9 | 2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$336.00   $235.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000IUH
Chemical Name:
2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-
CAS Number:
119509-24-9
Molecular Formula:
C15H21Cl2NO5
Molecular Weight:
366.2369
MDL Number:
MFCD01664873
SMILES:
C[C@H](C(=O)c1c(O)c(OC)c([nH]c1=O)OC)C[C@@H]([C@H](CCl)Cl)C
Properties
Computed Properties
 
Complexity:
544  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.8  

Literature

Title: A common mechanism links differently acting complex II inhibitors to cardioprotection: modulation of mitochondrial reactive oxygen species production.

Journal: Molecular pharmacology 20110501

Title: Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency.

Journal: Cell death and differentiation 20101201

Title: Synthetic atpenin analogs: Potent mitochondrial inhibitors of mammalian and fungal succinate-ubiquinone oxidoreductase.

Journal: Bioorganic & medicinal chemistry letters 20100301

Title: The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.

Journal: Acta biochimica Polonica 20100101

Title: Enantioselective total synthesis of atpenin A5.

Journal: The Journal of antibiotics 20090601

Title: The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.

Journal: Basic research in cardiology 20090301

Title: Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists.

Journal: PloS one 20090101

Title: Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction.

Journal: The Journal of biological chemistry 20060317

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 119509-24-9
137813-88-8

137813-88-8

 1231944-64-1

1231944-64-1
Building Blocks
More >
Historical Records
106368-34-7

106368-34-7

 1250429-03-8

1250429-03-8

 1991-98-6

1991-98-6

 1031969-33-1

1031969-33-1

 446852-23-9

446852-23-9

 361168-62-9

361168-62-9
Tags:119509-24-9 Molecular Formula|119509-24-9 MDL|119509-24-9 SMILES|119509-24-9 2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-
Catalog No.: AA000IUH
119509-24-9,MFCD01664873
119509-24-9 | 2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-
Pack Size： 1mg
Purity： ≥95%
in stock
$336.00 $235.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000IUH
Chemical Name: 2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-
CAS Number: 119509-24-9
Molecular Formula: C15H21Cl2NO5
Molecular Weight: 366.2369
MDL Number: MFCD01664873
SMILES: C[C@H](C(=O)c1c(O)c(OC)c([nH]c1=O)OC)C[C@@H]([C@H](CCl)Cl)C
Properties
Complexity: 544  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.8  
Literature fold

Title: A common mechanism links differently acting complex II inhibitors to cardioprotection: modulation of mitochondrial reactive oxygen species production.

Journal: Molecular pharmacology20110501

Title: Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency.

Journal: Cell death and differentiation20101201

Title: Synthetic atpenin analogs: Potent mitochondrial inhibitors of mammalian and fungal succinate-ubiquinone oxidoreductase.

Journal: Bioorganic & medicinal chemistry letters20100301

Title: The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.

Journal: Acta biochimica Polonica20100101

Title: Enantioselective total synthesis of atpenin A5.

Journal: The Journal of antibiotics20090601

Title: The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.

Journal: Basic research in cardiology20090301

Title: Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists.

Journal: PloS one20090101

Title: Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction.

Journal: The Journal of biological chemistry20060317

Related Products of of 119509-24-9
137813-88-8
137813-88-8
1231944-64-1
1231944-64-1
Building Blocks More >
1227578-45-1
1227578-45-1
2-Chloro-4-methoxy-6-methylpyridine
AA000J93 | MFCD16610591
1228230-82-7
1228230-82-7
3-(Methoxymethyl)-azetidine trifluoroacetate
AA000JHB | MFCD17016141
1229186-69-9
1229186-69-9
4-Amino-1-methylcyclohexanol hydrochloride
AA000JOR | MFCD19687277
1231930-33-8
1231930-33-8
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1h-benzo[d]imidazole
AA000K2F | MFCD16660227
1233698-83-3
1233698-83-3
6-Chloro-2-(dimethylamino)nicotinaldehyde
AA000KDC | MFCD21333091
1235318-89-4
1235318-89-4
2-Pyrimidinamine, 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
AA000KNT | MFCD21340285
123770-63-8
123770-63-8
(5-Isopropylisoxazol-3-yl)methanol
AA000KZZ | MFCD09859255
124-41-4
124-41-4
Methanol, sodium salt (1:1)
AA000LAG | MFCD00012179
1242156-53-1
1242156-53-1
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
AA000LM7 | MFCD22572858
124467-36-3
124467-36-3
2-Chloro-7,8-dihydroquinolin-5(6h)-one
AA000LZI | MFCD08692066
Historical Records
106368-34-7
106368-34-7
1250429-03-8
1250429-03-8
1991-98-6
1991-98-6
1031969-33-1
1031969-33-1
446852-23-9
446852-23-9
361168-62-9
361168-62-9
Submit
© 2017 AA BLOCKS, INC. All rights reserved.