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1235318-89-4,MFCD21340285
Catalog No.:AA000KNT

1235318-89-4 | 2-Pyrimidinamine, 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
in stock  
$156.00   $109.00
- +
10mg
95%
in stock  
$256.00   $179.00
- +
25mg
95%
in stock  
$358.00   $250.00
- +
250mg
95%
in stock  
$1,422.00   $995.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000KNT
Chemical Name:
2-Pyrimidinamine, 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
CAS Number:
1235318-89-4
Molecular Formula:
C12H12N6S
Molecular Weight:
272.3289
MDL Number:
MFCD21340285
SMILES:
Cc1ccnc(n1)Nc1sc(c(n1)c1c[nH]nc1)C
Properties
Computed Properties
 
Complexity:
304  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.2  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.370-374

Literature

Title: A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease.

Journal: The Journal of pharmacology and experimental therapeutics 20121001

Title: Fujinaga M, et al. Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)Cmethylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)CADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4). Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4.

Title: Ponnazhagan R, et al. The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. J Neuroimmune Pharmacol. 2016 Jun;11(2):231-7.

Title: Kalinichev M, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505.

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Tags:1235318-89-4 Molecular Formula|1235318-89-4 MDL|1235318-89-4 SMILES|1235318-89-4 2-Pyrimidinamine, 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
Catalog No.: AA000KNT
1235318-89-4,MFCD21340285
1235318-89-4 | 2-Pyrimidinamine, 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
Pack Size： 5mg
Purity： 95%
in stock
$156.00 $109.00
Pack Size： 10mg
Purity： 95%
in stock
$256.00 $179.00
Pack Size： 25mg
Purity： 95%
in stock
$358.00 $250.00
Pack Size： 250mg
Purity： 95%
in stock
$1,422.00 $995.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000KNT
Chemical Name: 2-Pyrimidinamine, 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
CAS Number: 1235318-89-4
Molecular Formula: C12H12N6S
Molecular Weight: 272.3289
MDL Number: MFCD21340285
SMILES: Cc1ccnc(n1)Nc1sc(c(n1)c1c[nH]nc1)C
Properties
Complexity: 304  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.2  
Downstream Synthesis Route
1235313-79-7    130645-48-6    1235318-89-4 

[1]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.370-374

Literature fold

Title: A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease.

Journal: The Journal of pharmacology and experimental therapeutics20121001

Title: Fujinaga M, et al. Radiosynthesis and evaluation of 5-methyl-N-(4-[(11)Cmethylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine ([(11)CADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4). Bioorg Med Chem Lett. 2016 Jan 15;26(2):370-4.

Title: Ponnazhagan R, et al. The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. J Neuroimmune Pharmacol. 2016 Jun;11(2):231-7.

Title: Kalinichev M, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. J Pharmacol Exp Ther. 2014 Sep;350(3):495-505.

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