Home Other Building Blocks 1196723-93-9
1196723-93-9,MFCD22580417
Catalog No.:AA0097CO

1196723-93-9 | HSF1A

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
98%
in stock  
$268.00   $188.00
- +
5mg
99%
in stock  
$303.00   $212.00
- +
10mg
98%
in stock  
$524.00   $367.00
- +
25mg
99%
in stock  
$892.00   $625.00
- +
50mg
98%
in stock  
$1,690.00   $1,183.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0097CO
Chemical Name:
HSF1A
CAS Number:
1196723-93-9
Molecular Formula:
C21H19N3O2S2
Molecular Weight:
409.5245
MDL Number:
MFCD22580417
SMILES:
CCc1ccc(cc1)S(=O)(=O)Nc1cc(nn1c1ccccc1)c1cccs1
Properties
Computed Properties
 
Complexity:
595  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.9  

Downstream Synthesis Route

[1]Patent:US2011/112073,2011,A1

[1]Patent:US2011/112073,2011,A1.Locationinpatent:Page/Pagecolumn21-22

Literature

Title: Neef DW, et al. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955-66.

Title: Neef DW, et al. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010 Jan 19;8(1):e1000291.

Title: Huang CY, et al. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016 Nov 3;7(11):e2455.

Title: Marcus Steinemann, et al. The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585.

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SDS
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