Home Oxazoles 1197300-24-5
1197300-24-5,MFCD17169972
Catalog No.:AA000PHA

1197300-24-5 | 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide

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1mg
98%
in stock  
$12.00   $8.00
- +
5mg
98%
in stock  
$27.00   $19.00
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10mg
98%
in stock  
$39.00   $28.00
- +
25mg
98%
in stock  
$66.00   $47.00
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100mg
98%
in stock  
$187.00   $131.00
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250mg
98%
in stock  
$317.00   $222.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000PHA
Chemical Name:
3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide
CAS Number:
1197300-24-5
Molecular Formula:
C18H14Cl2N2O2
Molecular Weight:
361.2220
MDL Number:
MFCD17169972
SMILES:
Clc1ccc(cc1)N(C(=O)c1c(C)onc1c1ccccc1Cl)C
Properties
Computed Properties
 
Complexity:
443  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
4.7  

Downstream Synthesis Route

[1]Evans,KarenA.;Budzik,BrianW.;Ross,SeanA.;Wisnoski,DavidD.;Jin,Jian;Rivero,RalphA.;Vimal,Mythily;Szewczyk,GeorgeR.;Jayawickreme,Channa;Moncol,DavidL.;Rimele,ThomasJ.;Armour,SusanL.;Weaver,SusanP.;Griffin,RobertJ.;Tadepalli,SarvaM.;Jeune,MichaelR.;Shearer,ToddW.;Chen,ZibinB.;Chen,Lihong;Anderson,DonaldL.;Becherer,J.David;DeLosFrailes,Maite;Colilla,FranciscoJavier[JournalofMedicinalChemistry,2009,vol.52,#24,p.7962-7965]

Literature

Title: Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20121001

Title: Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.

Journal: Journal of medicinal chemistry 20091224

Title: Evans KA, et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem. 2009 Dec 24;52(24):7962-5.

Title: Caldwell A, Grundy L, Harrington AM, Garcia-Caraballo S, Castro J, Bunnett NW, Brierley SM. TGR5 agonists induce peripheral and central hypersensitivity to bladder distension. Sci Rep. 2022 Jun 15;12(1):9920.

Title: Castellanos-Jankiewicz A, et al. Hypothalamic bile acid-TGR5 signaling protects from obesity. Cell Metab. 2021 Jul 6;33(7):1483-1492.e10.

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SDS
Tags:1197300-24-5 Molecular Formula|1197300-24-5 MDL|1197300-24-5 SMILES|1197300-24-5 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide