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120138-50-3,MFCD00865105
Catalog No.:AA008X5K

120138-50-3 | Quinupristin

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1mg
97%
in stock  
$145.00   $102.00
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5mg
97%
in stock  
$390.00   $273.00
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10mg
97%
in stock  
$568.00   $398.00
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25mg
97%
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$1,204.00   $843.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA008X5K
Chemical Name:
Quinupristin
CAS Number:
120138-50-3
Molecular Formula:
C54H71N9O13S2
Molecular Weight:
1118.3240
MDL Number:
MFCD00865105
SMILES:
[O-]S(=O)(=O)C.CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](N(C(=O)[C@H]3N(C1=O)CCC3)C)Cc1ccc(cc1)N(C)C)C[C@@H](CS[C@@H]1C[NH+]3CCC1CC3)C(=O)C2)c1ccccc1
Properties
Computed Properties
 
Complexity:
2010  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
73  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  
XLogP3:
4.2  

Literature

Title: Pharmacogenomic strategies against microbial resistance: from bright to bleak to innovative.

Journal: Pharmacogenomics 20100901

Title: [In vitro activities of quinupristin/dalfopristin in combination with vancomycin and gatifloxacin against Staphylococcus aureus and Enterococcus faecium clinical isolates].

Journal: Mikrobiyoloji bulteni 20090101

Title: [Persistent bacteremia caused by methicillin-resistant Staphylococcus aureus].

Journal: Enfermedades infecciosas y microbiologia clinica 20081101

Title: A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080601

Title: Transposon characterization of vancomycin-resistant Enterococcus faecium (VREF) and dissemination of resistance associated with transferable plasmids.

Journal: The Journal of antimicrobial chemotherapy 20070801

Title: [Therapeutic perspectives of linezolid in the management of infections due to multiresistant Gram-positive pathogens].

Journal: Recenti progressi in medicina 20070301

Title: In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus.

Journal: Indian journal of medical microbiology 20070101

Title: Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061201

Title: Prevalence of macrolide resistance genes among staphylococci in Cyprus.

Journal: Journal of chemotherapy (Florence, Italy) 20061001

Title: Newer antibiotics for serious gram-positive infections.

Journal: Cleveland Clinic journal of medicine 20060901

Title: Emergence of Enterococcus faecalis susceptible to quinupristin/dalfopristin in Greece.

Journal: International journal of antimicrobial agents 20060801

Title: Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis originating from endodontic infections in Finland and Lithuania.

Journal: Oral microbiology and immunology 20060601

Title: In vitro activity of quinupristin and dalfopristin in combination and alone against coryneform bacteria.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20051101

Title: In-vitro activity of quinupristin/dalfopristin, levofloxacin and moxifloxacin against fusidic acid and rifampicin-resistant strains of methicillin-resistant Staphylococcus aureus (MRSA) from Malaysian hospitals.

Journal: The Medical journal of Malaysia 20051001

Title: Emergence of Staphylococcus hominis strains expressing low-level resistance to quinupristin/dalfopristin in Greece.

Journal: The Journal of antimicrobial chemotherapy 20050501

Title: In vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against Propionibacterium acnes isolates from central nervous system infections.

Journal: The Journal of antimicrobial chemotherapy 20050201

Title: In vitro activity of linezolid & quinupristin/dalfopristin against Gram-positive cocci.

Journal: The Indian journal of medical research 20041201

Title: Use of quinupristin/dalfopristin in a critical patient with a methicillin-resistant Staphilococcus aureus infection.

Journal: Minerva anestesiologica 20041001

Title: Relationship between myalgias/arthralgias occurring in patients receiving quinupristin/dalfopristin and biliary dysfunction.

Journal: The Journal of antimicrobial chemotherapy 20040601

Title: In vitro activity of telithromycin, quinupristin/dalfopristin, linezolid and comparator antimicrobial agents against Staphylococcus aureus clinical isolates.

Journal: Journal of chemotherapy (Florence, Italy) 20040601

Title: Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin.

Journal: BMC biology 20040101

Title: What is the role of streptogramins in intensive care?

Journal: Journal of chemotherapy (Florence, Italy) 20031101

Title: Role of quinupristin/dalfopristin in the treatment of Gram-positive nosocomial infections in haematological or oncological patients.

Journal: Cancer treatment reviews 20031001

Title: Quinupristin/dalfopristin-induced Sweet's syndrome.

Journal: The Korean journal of internal medicine 20030901

Title: Endocarditis due to vancomycin-resistant Enterococcus faecium in an immunocompromised patient: cure by administering combination therapy with quinupristin/dalfopristin and high-dose ampicillin.

Journal: Southern medical journal 20030801

Title: Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.

Journal: The Journal of parasitology 20030801

Title: Intra-hospital dissemination of quinupristin/dalfopristin- and vancomycin-resistant Enterococcus faecium in a paediatric ward of a German hospital.

Journal: The Journal of antimicrobial chemotherapy 20030701

Title: Treatment of central nervous system infection by vancomycin-resistant enterococcus faecium.

Journal: Diagnostic microbiology and infectious disease 20030301

Title: [Other antimicrobial agents (linezolid, quinupristin/dalfopristin, glycylcycline etc)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030301

Title: [Other antimicrobials (linezolid, quinupristin/dalfopristin)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report.

Journal: Infection 20021001

Title: Comparative in vitro activity of penicillin G, levofloxacin, moxifloxacin, telithromycin, pristinamycin, quinupristin-dalfopristin and linezolid against ofloxacin-intermediate and -resistant Streptococcus pneumoniae.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20021001

Title: Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients.

Journal: The Pediatric infectious disease journal 20021001

Title: Quinupristin/dalfopristin.

Journal: Expert opinion on pharmacotherapy 20020901

Title: Clinical experience with quinupristin-dalfopristin as rescue treatment of critically ill patients infected with methicillin-resistant staphylococci.

Journal: Intensive care medicine 20020801

Title: Clinical experience of quinupristin-dalfopristin for the treatment of antimicrobial-resistant gram-positive infections.

Journal: Pharmacotherapy 20020601

Title: Combination of quinupristin/dalfopristin and glycopeptide in severe methicillin-resistant staphylococcal infections failing previous glycopeptide regimens.

Journal: Infection 20020601

Title: In vitro activity of a new cephalosporin, RWJ-54428, against streptococci, enterococci and staphylococci, including glycopeptide-intermediate Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20020501

Title: [Novel compounds active on staphylococci].

Journal: Annales francaises d'anesthesie et de reanimation 20020501

Title: Molecular characterization of ketolide-resistant erm(A)-carrying Staphylococcus aureus isolates selected in vitro by telithromycin, ABT-773, quinupristin and clindamycin.

Journal: The Journal of antimicrobial chemotherapy 20020401

Title: [symbol: see text]Quinupristin + dalfopristin for infections.

Journal: Drug and therapeutics bulletin 20020201

Title: Molecular analysis of constitutively expressed erm(C) genes selected in vitro by incubation in the presence of the noninducers quinupristin, telithromycin, or ABT-773.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20020101

Title: Quinupristin-dalfopristin: a new antibiotic for severe gram-positive infections.

Journal: American family physician 20011201

Title: Treatment of vancomycin-resistant enterococcal infections in the immunocompromised host: quinupristin-dalfopristin in combination with minocycline.

Journal: Antimicrobial agents and chemotherapy 20011101

Title: In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii.

Journal: Antimicrobial agents and chemotherapy 20011101

Title: Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens.

Journal: The New England journal of medicine 20011018

Title: Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis.

Journal: Biochemistry 20010731

Title: Antibiotic resistance rates and macrolide resistance phenotypes of viridans group streptococci from the oropharynx of healthy Greek children.

Journal: International journal of antimicrobial agents 20010301

Title: Antistaphylococcal (MSSA, MRSA, MSSE, MRSE) antibiotics.

Journal: The Medical clinics of North America 20010101

Title: Quinupristin/dalfopristin: a therapeutic review.

Journal: Clinical therapeutics 20010101

Title: Quinupristin/dalfopristin and linezolid: spectrum of activity and potential roles in therapy--a status report.

Journal: Current clinical topics in infectious diseases 20010101

Title: [Quinupristin/dalfopristin].

Journal: Revista de medicina de la Universidad de Navarra 20010101

Title: Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections.

Journal: Drugs 19991201

Title: Quinupristin-dalfopristin is active against Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 19990801

Title: Gurk-Turner C. Quinupristin/dalfopristin: the first available macrolide-lincosamide-streptogramin antibiotic. Proc (Bayl Univ Med Cent). 2000 Jan;13(1):83-6.

Title: Tantibhedhyangkul W, et al. Anti-Mycoplasma Activity of Daptomycin and Its Use for Mycoplasma Elimination in Cell Cultures of Rickettsiae. Antibiotics (Basel). 2019 Aug 21;8(3).

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