Home Amines 120225-54-9
120225-54-9,MFCD00877010
Catalog No.:AA000LKF

120225-54-9 | 3-{4-[2-({6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl}amino)ethyl]phenyl}propanoic acid hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$36.00   $25.00
- +
5mg
98%
in stock  
$90.00   $63.00
- +
10mg
98%
in stock  
$143.00   $100.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000LKF
Chemical Name:
3-{4-[2-({6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl}amino)ethyl]phenyl}propanoic acid hydrochloride
CAS Number:
120225-54-9
Molecular Formula:
C23H29N7O6
Molecular Weight:
499.5197
MDL Number:
MFCD00877010
SMILES:
CCNC(=O)C1OC(C(C1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N
Properties

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2012,vol.55,p.538-552

[1]JournalofMedicinalChemistry,2012,vol.55,p.538-552

[1]JournalofMedicinalChemistry,2012,vol.55,p.538-552

[1]JournalofMedicinalChemistry,2012,vol.55,p.538-552

[1]JournalofMedicinalChemistry,2012,vol.55,p.538-552

Literature

Title: Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38(3):969-75.

Title: Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2-(aryl)alkylthioadenosine derivatives.

Title: Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.

Title: Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.

Title: Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522(1):21-4.

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Tags:120225-54-9 Molecular Formula|120225-54-9 MDL|120225-54-9 SMILES|120225-54-9 3-{4-[2-({6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl}amino)ethyl]phenyl}propanoic acid hydrochloride