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Home Other Building Blocks 1206799-15-6
1206799-15-6,MFCD23160048
Catalog No.:AA003AJV

1206799-15-6 | LY2801653

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$89.00   $62.00
- +
5mg
≥98%
in stock  
$258.00   $180.00
- +
10mg
98%
in stock  
$375.00   $263.00
- +
25mg
98%
in stock  
$774.00   $542.00
- +
50mg
98%
in stock  
$1,011.00   $708.00
- +
100mg
98%
in stock  
$1,415.00   $990.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003AJV
Chemical Name:
LY2801653
CAS Number:
1206799-15-6
Molecular Formula:
C30H22F2N6O3
Molecular Weight:
552.5309
MDL Number:
MFCD23160048
SMILES:
Fc1ccc(cc1)n1c(C)ccc(c1=O)C(=O)Nc1ccc(c(c1)F)Oc1cc2cnn(c2cc1c1c[nH]nc1)C
Properties
Computed Properties
 
Complexity:
1050  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4.7  

Downstream Synthesis Route

[1]OrganicProcessResearchandDevelopment,2014,vol.18,p.501-510

[2]Patent:US2010/22529,2010,A1.Locationinpatent:Page/Pagecolumn18-19

N-(3-fluoro-4-(1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yloxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamidehydrochloride 
  1206799-15-6 

[1]Patent:US2010/22529,2010,A1.Locationinpatent:Page/Pagecolumn19

[1]OrganicProcessResearchandDevelopment,2014,vol.18,p.501-510

[2]OrganicProcessResearchandDevelopment,2014,vol.18,p.501-510

[1]OrganicProcessResearchandDevelopment,2014,vol.18,p.501-510

[1]OrganicProcessResearchandDevelopment,2014,vol.18,p.501-510

Literature

Title: TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.

Journal: Immunological reviews 20170301

Title: Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.

Journal: Nature immunology 20150801

Title: LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.

Journal: Investigational new drugs 20130801

Title: Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity.

Journal: Cancer discovery 20130701

Title: Yan SB, et al. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. Invest New Drugs. 2013 Aug;31(4):833-44.

Title: Barat S, et al. Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma. Mol Carcinog. 2016 Jan 12.

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SDS
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