Name: Name:AM-679
Brand: AABLOCKS
SKU: AA008TAM
Rating: 90 (10 reviews)

Catalog No.: AA008TAM

1206880-66-1 | AM-679

Pack Size： 5mg

Purity： 99%

1 week

$384.00 $269.00

Pack Size： 10mg

Purity： 99%

1 week

$574.00 $402.00

Pack Size： 50mg

Purity： 99%

1 week

$1,320.00 $924.00

Pack Size： 100mg

Purity： 99%

1 week

$2,035.00 $1,424.00

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Technical Information

Catalog Number: AA008TAM

Chemical Name: AM-679

CAS Number: 1206880-66-1

Molecular Formula: C40H44N4O5S

Molecular Weight: 692.8662

MDL Number: MFCD20527236

SMILES: COc1cnc(nc1)c1ccc(cc1)Cn1c2ccc(cc2c(c1CC(C(=O)O)(C)C)SC(C)(C)C)OCC1Cc2c(N1C(=O)C)cccc2

Properties

Complexity: 1150

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 50

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 12

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 6.9

Literature fold

Title: 5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.

Journal: Bioorganic & medicinal chemistry letters20100101

Title: Musiyenko, A, et al. A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye. Clinical and Vaccine Immunology (2009), 16(11), 1654-1659.

Title: Stock, N, et al. 5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1--(5-methoxy-pyrimidin-2-yl)-benzyl-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)-A potent FLAP inhibitor. Bioorganic & Medicinal Chemistry Letters (2010), 20(1), 213-217.

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