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120934-96-5,MFCD00274043
Catalog No.:AA007PA2

120934-96-5 | 1H-Pyrrole-3-carboxylicacid, 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-, methyl ester

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1mg
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$46.00   $32.00
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5mg
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$100.00   $70.00
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10mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007PA2
Chemical Name:
1H-Pyrrole-3-carboxylicacid, 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-, methyl ester
CAS Number:
120934-96-5
Molecular Formula:
C22H21NO3
Molecular Weight:
347.4070
MDL Number:
MFCD00274043
SMILES:
COC(=O)c1c(C)[nH]c(c1C(=O)c1ccccc1Cc1ccccc1)C
Properties
Computed Properties
 
Complexity:
500  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.6  

Literature

Title: Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility.

Journal: Experimental physiology 20120501

Title: Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20120501

Title: An anticholinergic reverses motor control and corticostriatal LTD deficits in Dyt1 ΔGAG knock-in mice.

Journal: Behavioural brain research 20120115

Title: Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration.

Journal: Cell calcium 20110301

Title: Ionic currents in intimal cultured synoviocytes from the rabbit.

Journal: American journal of physiology. Cell physiology 20101101

Title: Voltage-gated divalent currents in descending vasa recta pericytes.

Journal: American journal of physiology. Renal physiology 20101001

Title: Comparative effects of T-type and L-type Ca(2+)-antagonists against noradrenaline-induced contractions of human vas deferens.

Journal: BJU international 20100801

Title: Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil.

Journal: Journal of veterinary science 20100601

Title: Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx.

Journal: The Journal of biological chemistry 20100305

Title: Contractile actions of L-type Ca2+ agonists in human vas deferens and effects of structurally different Ca2+ antagonists.

Journal: European journal of pharmacology 20100210

Title: Acute atrial arrhythmogenesis in murine hearts following enhanced extracellular Ca(2+) entry depends on intracellular Ca(2+) stores.

Journal: Acta physiologica (Oxford, England) 20100201

Title: Acute ethanol treatment prevents endocannabinoid-mediated long-lasting disinhibition of striatal output.

Journal: Neuropharmacology 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.

Journal: The Journal of pharmacology and experimental therapeutics 20090701

Title: Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels.

Journal: Brain research 20090618

Title: Activity-dependent modulation of limbic dopamine D3 receptors by CaMKII.

Journal: Neuron 20090212

Title: Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts.

Journal: Experimental physiology 20090201

Title: Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity.

Journal: The European journal of neuroscience 20090101

Title: Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.

Journal: Journal of pharmacological and toxicological methods 20090101

Title: Small-molecule activation of neuronal cell fate.

Journal: Nature chemical biology 20080701

Title: A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria.

Journal: European journal of pharmacology 20071208

Title: Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures.

Journal: Neurochemical research 20071001

Title: Combined activation of L-type Ca2+ channels and synaptic transmission is sufficient to induce striatal long-term depression.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070620

Title: Calcium influx through L-type channels generates protein kinase M to induce burst firing of dopamine cells in the rat ventral tegmental area.

Journal: The Journal of biological chemistry 20070323

Title: Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060719

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Intracellular acidification in neurons induced by ammonium depends on KCC2 function.

Journal: The European journal of neuroscience 20060101

Title: FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current.

Journal: Biophysical journal 20050101

Title: L-type calcium channel agonist induces correlated depolarizations in mice lacking the beta2 subunit nAChRs.

Journal: Vision research 20041201

Title: Facilitation of L-type Ca2+ channels in dendritic spines by activation of beta2 adrenergic receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040929

Title: Modulation of single channels underlying hippocampal L-type current enhancement by agonists depends on the permeant ion.

Journal: Journal of neurophysiology 20040801

Title: FPL-64176 alters both charge movement and Ca2+ release properties in amphibian muscle fibres.

Journal: Pflugers Archiv : European journal of physiology 20040301

Title: DHP-insensitive L-type-like Ca channel of ascidian acquires sensitivity to DHP with single amino acid change in domain III P-region.

Journal: FEBS letters 20030814

Title: The calcium channel ligand FPL 64176 enhances L-type but inhibits N-type neuronal calcium currents.

Journal: Neuropharmacology 20030801

Title: Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.

Journal: Molecular pharmacology 20030801

Title: Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.

Journal: Brain research. Molecular brain research 20030723

Title: Activation of cardiac ryanodine receptors by the calcium channel agonist FPL-64176.

Journal: American journal of physiology. Heart and circulatory physiology 20020701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Phase I and phase II of short-term mechanical restitution in perfused rat left ventricles.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: Effects of FPL 64176 on Ca transients in voltage-clamped rat ventricular myocytes.

Journal: British journal of pharmacology 20020301

Title: Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death.

Journal: The Journal of biological chemistry 20011026

Title: Control of secretion by mitochondria depends on the size of the local [Ca2+] after chromaffin cell stimulation.

Journal: The European journal of neuroscience 20010601

Title: Arachidonic acid reversibly enhances N-type calcium current at an extracellular site.

Journal: American journal of physiology. Cell physiology 20010501

Title: Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner.

Journal: Brain research 20010202

Title: Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.

Journal: Molecular pharmacology 19911101

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Tags:120934-96-5 Molecular Formula|120934-96-5 MDL|120934-96-5 SMILES|120934-96-5 1H-Pyrrole-3-carboxylicacid, 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-, methyl ester