Home Amines 121-30-2
121-30-2,MFCD00007933
Catalog No.:AA003KNH

121-30-2 | 4-Amino-6-chloro-1,3-benzenedisulfonamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
97%
in stock  
$6.00   $4.00
- +
5g
97%
in stock  
$7.00   $5.00
- +
10g
97%
in stock  
$9.00   $7.00
- +
25g
97%
in stock  
$12.00   $8.00
- +
100g
97%
in stock  
$35.00   $25.00
- +
500g
97%
in stock  
$165.00   $116.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003KNH
Chemical Name:
4-Amino-6-chloro-1,3-benzenedisulfonamide
CAS Number:
121-30-2
Molecular Formula:
C6H8ClN3O4S2
Molecular Weight:
285.7284
MDL Number:
MFCD00007933
SMILES:
Nc1cc(Cl)c(cc1S(=O)(=O)N)S(=O)(=O)N
NSC Number:
93772
Properties
Properties
 
BP:
614.4°C at 760 mmHg  
Form:
Solid  
MP:
257-261 °C(lit.)  
Refractive Index:
1.6100 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
451  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
-0.5  

Upstream Synthesis Route

[1]Patent:US2011/263579,2011,A1,.Locationinpatent:Page/Pagecolumn9

[1]Patent:WO2009/150497,2009,A1,.Locationinpatent:Page/Pagecolumn9

[2]Pharmazie,1987,vol.42,#3,p.162-164

[3]JournaloftheAmericanChemicalSociety,1960,vol.82,p.1161-1166

[4]JournalofOrganicChemistry,1960,vol.25,p.970-981

[5]JournaloftheAmericanChemicalSociety,1960,vol.82,p.1132-1135

[6]JournalofOrganicChemistry,1961,vol.26,p.3842-3850

[7]JournalfuerPraktischeChemie(Leipzig),1962,vol.16,p.264-276

[8]Patent:WO2007/26376,2007,A2,.Locationinpatent:Page/Pagecolumn7

[9]Patent:WO2007/26376,2007,A2,.Locationinpatent:Page/Pagecolumn8

[10]Patent:WO2007/26376,2007,A2,.Locationinpatent:Page/Pagecolumn8

[11]Patent:CN103396381,2016,B,.Locationinpatent:Paragraph0027-0030

[12]Patent:CN105272937,2016,A,.Locationinpatent:Paragraph0014-0015

[13]Tetrahedron,2018,vol.74,#51,p.7237-7241

[1]TetrahedronLetters,2018,vol.59,#21,p.2099-2102

[1]JournalofOrganicChemistry,1961,vol.26,p.3842-3850

[2]JournalfuerPraktischeChemie(Leipzig),1962,vol.16,p.264-276

[1]Bollettinochimicofarmaceutico,1961,vol.100,p.956-971

Downstream Synthesis Route

[1]Cragoe,E.J.etal.[Journalofmedicinalandpharmaceuticalchemistry,1962,vol.5,p.896-912]

[2]Ravina;Montanes;Cobreros;Tato[Chimicatherapeutica,1973,vol.8,#3,p.290-296]

[1]CurrentPatentAssignee:ALEMBICLTD-WO2009/150497,2009,A1Locationinpatent:Page/Pagecolumn9

[2]Henning;Scholz;Wolf[Pharmazie,1987,vol.42,#3,p.162-164]

[3]Werner,L.H.etal.[JournaloftheAmericanChemicalSociety,1960,vol.82,p.1161-1166]

[4]Novello,F.C.etal.[JournalofOrganicChemistry,1960,vol.25,p.970-981]

[5]Close,W.J.etal.[JournaloftheAmericanChemicalSociety,1960,vol.82,p.1132-1135]

[6]Topliss,J.G.etal.[JournalofOrganicChemistry,1961,vol.26,p.3842-3850]

[7]Klosa,J.;Voigt,H.[JournalfurpraktischeChemie(Leipzig1954),1962,vol.16,p.264-276]

[8]CurrentPatentAssignee:UNICHEMLABORATORIESLIMITED-WO2007/26376,2007,A2Locationinpatent:Page/Pagecolumn7

[9]CurrentPatentAssignee:UNICHEMLABORATORIESLIMITED-WO2007/26376,2007,A2Locationinpatent:Page/Pagecolumn8

[10]CurrentPatentAssignee:UNICHEMLABORATORIESLIMITED-WO2007/26376,2007,A2Locationinpatent:Page/Pagecolumn8

[11]CurrentPatentAssignee:ANYANGJIUZHOUPHARMACEUTICAL-CN103396381,2016,BLocationinpatent:Paragraph0027-0030

[12]CurrentPatentAssignee:CHANGZHOUPHARMACEUTICALFACTORYCO.,LTD.-CN105272937,2016,ALocationinpatent:Paragraph0014-0015

[13]Kitanosono,Taku;Cho,SooMin;Kobayashi,Shū[Tetrahedron,2018,vol.74,#51,p.7237-7241]

[1]JournalofOrganicChemistry,1961,vol.26,p.2809-2813

[1]Whitehead,C.W.etal.[JournalofOrganicChemistry,1961,vol.26,p.2814-2818]

[1]Journalofmedicinalandpharmaceuticalchemistry,1962,vol.5,p.896-912

Literature

Title: Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.

Journal: Journal of medicinal chemistry 20120412

Title: Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.

Journal: Bioorganic & medicinal chemistry 20120401

Title: Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.

Journal: Bioorganic & medicinal chemistry 20120215

Title: Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.

Journal: Bioorganic & medicinal chemistry 20110815

Title: A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.

Journal: Bioorganic & medicinal chemistry 20110201

Title: Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.

Journal: Bioorganic & medicinal chemistry letters 20110115

Title: Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.

Journal: Bioorganic & medicinal chemistry 20100801

Title: 3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100515

Title: Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

Journal: Journal of medicinal chemistry 20100311

Title: Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.

Journal: Bioorganic & medicinal chemistry 20090715

Title: Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.

Journal: Bioorganic & medicinal chemistry 20090701

Title: Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.

Journal: Journal of medicinal chemistry 20090514

Title: Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.

Journal: Journal of medicinal chemistry 20090423

Title: Carbonic anhydrase inhibitors. Biphenylsulfonamides with inhibitory action towards the transmembrane, tumor-associated isozymes IX possess cytotoxic activity against human colon, lung and breast cancer cell lines.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090401

Title: Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis.

Journal: Journal of chromatography. A 20090320

Title: A novel class of allosteric modulators of AMPA/Kainate receptors.

Journal: Bioorganic & medicinal chemistry letters 20090215

Title: Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.

Journal: Bioorganic & medicinal chemistry 20090201

Title: Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.

Journal: Bioorganic & medicinal chemistry 20071201

Title: Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.

Journal: Bioorganic & medicinal chemistry letters 20070801

Title: Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.

Journal: Journal of medicinal chemistry 20070125

Title: Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.

Journal: Bioorganic & medicinal chemistry letters 20060415

Title: QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.

Journal: Bioorganic & medicinal chemistry letters 20060401

Title: Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.

Journal: Journal of medicinal chemistry 20060323

Title: Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.

Journal: Journal of medicinal chemistry 20051201

Title: Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.

Journal: Bioorganic & medicinal chemistry letters 20050901

Title: Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.

Journal: Bioorganic & medicinal chemistry letters 20041220

Title: Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.

Journal: Bioorganic & medicinal chemistry letters 20041115

Title: Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.

Journal: Bioorganic & medicinal chemistry letters 20040621

Title: Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Mass spectrometric behavior of thiazide-based diuretics after electrospray ionization and collision-induced dissociation.

Journal: Analytical chemistry 20020801

Title: Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.

Journal: Journal of medicinal chemistry 20020328

Title: Isolation of a 2:1 hydrochlorothiazide-formaldehyde adduct impurity in hydrochlorothiazide drug substance by preparative chromatography and characterization by electrospray ionization LC-MS.

Journal: Journal of pharmaceutical and biomedical analysis 20011101

Title: Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.

Journal: Bioorganic & medicinal chemistry letters 20010226

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 121-30-2
Tags:121-30-2 Molecular Formula|121-30-2 MDL|121-30-2 SMILES|121-30-2 4-Amino-6-chloro-1,3-benzenedisulfonamide