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Home Amines 121-66-4
121-66-4,MFCD00005326
Catalog No.:AA003313

121-66-4 | 2-Amino-5-nitrothiazole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10g
97%
in stock  
$6.00   $4.00
- +
25g
97%
in stock  
$7.00   $5.00
- +
100g
97%
in stock  
$14.00   $10.00
- +
500g
97%
in stock  
$53.00   $37.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003313
Chemical Name:
2-Amino-5-nitrothiazole
CAS Number:
121-66-4
Molecular Formula:
C3H3N3O2S
Molecular Weight:
145.1398
MDL Number:
MFCD00005326
SMILES:
Nc1ncc(s1)N(=O)=O
NSC Number:
4
UN Number:
2811
Properties
Properties
 
BP:
345.1 °C at 760 mmHg  
Form:
Solid  
MP:
195-200 °C  
Refractive Index:
1.6740 (estimate)  
Solubility:
95% ethanol: soluble1g/150g at 20°C  
Stability:
Light Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
125  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.8  

Upstream Synthesis Route

[1]Phosphorus,SulfurandSiliconandtheRelatedElements,1993,vol.74,#1-4,p.249-260

[2]ChemMedChem,2014,vol.9,#8,p.1850-1859

[3]Proceedings-IndianAcademyofSciences,SectionA,1945,#22,p.362,376

[4]HelveticaChimicaActa,1950,vol.33,p.306,312

[5]TetrahedronLetters,1997,vol.38,#12,p.2085-2086

[6]Patent:US5883110,1999,A,

[7]Patent:US6080772,2000,A,

[8]Patent:US5798374,1998,A,

[9]Patent:US5883110,1999,A,

[10]RussianJournalofGeneralChemistry,2010,vol.80,#12,p.2572-2589

[1]Patent:US6080772,2000,A,

[2]Patent:US6080772,2000,A,

[3]Patent:US6080772,2000,A,

[1]Phosphorus,SulfurandSiliconandtheRelatedElements,1993,vol.74,#1-4,p.249-260

[1]Proceedings-IndianAcademyofSciences,SectionA,1945,#22,p.362,376

[2]GalenicaActa,1959,vol.12,p.249,252

[3]JournalofOrganicChemistry,1955,vol.20,p.499,505

[4]TetrahedronLetters,1997,vol.38,#12,p.2085-2086

[5]RussianJournalofGeneralChemistry,2010,vol.80,#12,p.2572-2589

[1]CanadianJournalofChemistry,1956,vol.34,p.1261,1267

[2]SyntheticCommunications,2001,vol.31,#19,p.2921-2927

Downstream Synthesis Route

[1]Patent:US2617809,1950,

[1]Huffman[JournalofOrganicChemistry,1958,vol.23,p.727]Bushby;Copp[JournaldePharmacologie,1955,vol.7,p.112,116]

[1]AnnalidiChimicaApplicata,1948,vol.38,p.449,454

[2]BulletindelaSocieteChimiquedeFrance,1955,p.1594,1596

[3]Galenicaacta,1959,vol.12,p.249,252

[1]Phosphorus,SulfurandSiliconandtheRelatedElements,1993,vol.74,p.249-260

[2]ChemMedChem,2014,vol.9,p.1850-1859

[3]Proceedings-IndianAcademyofSciences,SectionA,1945,p.362,376

[4]TetrahedronLetters,1997,vol.38,p.2085-2086

[5]Patent:US5883110,1999,A

[6]Patent:US6080772,2000,A

[7]Patent:US5798374,1998,A

[8]RussianJournalofGeneralChemistry,2010,vol.80,p.2572-2589

[1]Proceedings-IndianAcademyofSciences,SectionA,1945,p.362,376

Literature

Title: Assessment of the sensitizing potential of textile disperse dyes and some of their metabolites by the loose-fit coculture-based sensitization assay (LCSA).

Journal: Archives of toxicology 20120501

Title: Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis.

Journal: PLoS pathogens 20120501

Title: Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.

Journal: Bioorganic & medicinal chemistry letters 20120301

Title: N-(4-Meth-oxy-phen-yl)-N'-(5-nitro-1,3-thia-zol-2-yl)urea.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide.

Journal: Bioorganic & medicinal chemistry letters 20100615

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis and ex vivo evaluation of carbon-11 labelled N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea ([11C]AR-A014418): a radiolabelled glycogen synthase kinase-3beta specific inhibitor for PET studies.

Journal: Bioorganic & medicinal chemistry letters 20051201

Title: Cryptobia iubilans infection in juvenile discus.

Journal: Journal of the American Veterinary Medical Association 20040515

Title: 2-Amino-5-nitrothiazole monoethanol solvate: triply-interwoven hydrogen-bonded sheets containing centrosymmetric R2 2(8) and RR10 10(38) rings.

Journal: Acta crystallographica. Section C, Crystal structure communications 20040101

Title: Bioassay of 2-amino-5-nitrothiazole for possible carcinogenicity.

Journal: National Cancer Institute carcinogenesis technical report series 19780101

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