Catalog No.:AA009XSB

1215197-37-7 | (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid

Name: Name:(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
Brand: AABLOCKS
SKU: AA009XSB
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5mg

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10mg

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25mg

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$622.00 $435.00

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50mg

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100mg

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA009XSB

Chemical Name:

(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid

CAS Number:

1215197-37-7

Molecular Formula:

C18H19F3N4O3

Molecular Weight:

396.3637

MDL Number:

MFCD27938256

SMILES:

O=C([C@@H](n1cnc(c1)C(F)(F)F)CC1CCCC1)Nc1ccc(cn1)C(=O)O

Properties

Computed Properties

Complexity:

569

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

3.3

Literature

Title: In vitro antitumor mechanism of (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide.

Journal: Molecular pharmacology 20150101

Title: Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Journal: Journal of medicinal chemistry 20120209

Title: Erion DM, et al. The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. PLoS One. 2014 May 23;9(5):e97139.

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