Title: ATP depletion triggers acute myeloid leukemia differentiation through an ATR/Chk1 protein-dependent and p53 protein-independent pathway.
Journal: The Journal of biological chemistry 20120706
Title: Celecoxib enhances the radiosensitizing effect of 7-hydroxystaurosporine (UCN-01) in human lung cancer cell lines.
Journal: International journal of radiation oncology, biology, physics 20120701
Title: Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe.
Journal: Molecular cancer research : MCR 20120501
Title: Chk'ing p53-deficient breast cancers.
Journal: The Journal of clinical investigation 20120402
Title: Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
Journal: The Journal of clinical investigation 20120402
Title: A phase II study of cell cycle inhibitor UCN-01 in patients with metastatic melanoma: a California Cancer Consortium trial.
Journal: Investigational new drugs 20120401
Title: ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
Journal: DNA repair 20120301
Title: Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.
Journal: Molecular cancer therapeutics 20120201
Title: Roles of phosphoinositide-dependent kinase-1 in α1B-adrenoceptor phosphorylation and desensitization.
Journal: European journal of pharmacology 20120115
Title: Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC.
Journal: Biochemical and biophysical research communications 20120113
Title: Phase I trial of 7-hydroxystaurosporine and fludararbine phosphate: in vivo evidence of 7-hydroxystaurosporine induced apoptosis in chronic lymphocytic leukemia.
Journal: Leukemia & lymphoma 20111201
Title: M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.
Journal: Biochemical pharmacology 20111201
Title: Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.
Journal: Cell cycle (Georgetown, Tex.) 20111201
Title: Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK via PKCα-mediated MKP-1 induction.
Journal: Cardiovascular research 20111101
Title: Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110901
Title: A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies.
Journal: Cancer chemotherapy and pharmacology 20110601
Title: Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.
Journal: ACS chemical biology 20110520
Title: Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage.
Journal: Apoptosis : an international journal on programmed cell death 20110501
Title: Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01.
Journal: Molecular cancer therapeutics 20110501
Title: The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.
Journal: Cell cycle (Georgetown, Tex.) 20110215
Title: Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.
Journal: Mutation research 20110110
Title: Protein kinase C βII and δ/θ play critical roles in bone morphogenic protein-4-stimulated osteoblastic differentiation of MC3T3-E1 cells.
Journal: Biochemical and biophysical research communications 20101203
Title: Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
Journal: Molecular pharmacology 20101101
Title: PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.
Journal: Molecular cancer therapeutics 20101101
Title: Sodium butyrate with UCN-01 has marked antitumour activity against cervical cancer cells.
Journal: Anticancer research 20101001
Title: p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors.
Journal: Cell proliferation 20100801
Title: Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors.
Journal: Journal of molecular modeling 20100701
Title: Targeting slow-proliferating ovarian cancer cells.
Journal: International journal of cancer 20100515
Title: Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells.
Journal: American journal of physiology. Renal physiology 20100201
Title: A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.
Journal: Cell cycle (Georgetown, Tex.) 20100115
Title: A phase I trial of UCN-01 and prednisone in patients with refractory solid tumors and lymphomas.
Journal: Cancer chemotherapy and pharmacology 20100101
Title: Constitutive activation of the DNA damage signaling pathway in acute myeloid leukemia with complex karyotype: potential importance for checkpoint targeting therapy.
Journal: Cancer research 20091115
Title: Radiotherapy in conjunction with 7-hydroxystaurosporine: a multimodal approach with tumor pO2 as a potential marker of therapeutic response.
Journal: Radiation research 20091101
Title: Interaction with checkpoint kinase 1 modulates the recruitment of nucleophosmin to chromatin.
Journal: Journal of proteome research 20091001
Title: The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer?
Journal: Cancer biology & therapy 20090801
Title: Cell cycle kinases as therapeutic targets for cancer.
Journal: Nature reviews. Drug discovery 20090701
Title: Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090301
Title: Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.
Journal: Blood 20080915
Title: Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells.
Journal: Cell cycle (Georgetown, Tex.) 20080701
Title: G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.
Journal: Oncogene 20080619
Title: DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2.
Journal: Cell cycle (Georgetown, Tex.) 20080601
Title: Controlled release of a protein kinase inhibitor UCN-01 from liposomes influenced by the particle size.
Journal: International journal of pharmaceutics 20080303
Title: Phase I and pharmacokinetic study of UCN-01 in combination with irinotecan in patients with solid tumors.
Journal: Cancer chemotherapy and pharmacology 20080301
Title: Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo.
Journal: Molecular cancer therapeutics 20080301
Title: Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
Journal: Molecular cancer therapeutics 20080201
Title: Increased inducible nitric oxide synthase in lung carcinoma of smokers.
Journal: Cancer 20080115
Title: p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
Journal: Radiation research 20071201
Title: AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation.
Journal: Cancer letters 20071108
Title: MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.
Journal: Blood 20070915
Title: UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium.
Journal: Gynecologic oncology 20070801
Title: Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
Journal: Blood 20070515
Title: Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070501
Title: Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials.
Journal: Molecular cancer therapeutics 20070501
Title: [Research on cyclin-dependent kinase inhibitors: state of the art and perspective].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20070501
Title: UCN-01 (7-hydroxystaurosporine) induces apoptosis and G1 arrest of both primary and metastatic oral cancer cell lines in vitro.
Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301
Title: p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
Journal: Cancer cell 20070201
Title: 7-Hydroxystaurosporine may have a therapeutic role in treatment-resistant depression by inhibition of calcium/calmodulin-dependent protein kinase II.
Journal: Medical hypotheses 20070101
Title: Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation.
Journal: Cancer research 20070101
Title: Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.
Journal: Molecular pharmacology 20061201
Title: Modulation of cell cycle progression in human tumors: a pharmacokinetic and tumor molecular pharmacodynamic study of cisplatin plus the Chk1 inhibitor UCN-01 (NSC 638850).
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061201
Title: The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.
Journal: The Journal of biological chemistry 20061013
Title: Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01.
Journal: British journal of cancer 20060522
Title: p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
Journal: Oncogene 20060511
Title: On the observed large interspecies overprediction of human clearance ('vertical allometry') of UCN-01: further support for a proposed model based on plasma protein binding.
Journal: Journal of clinical pharmacology 20060401
Title: Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase.
Journal: Molecular and cellular biology 20060401
Title: Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial.
Journal: Blood 20060315
Title: Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060201
Title: Transient exposure of mammary tumors to PD184352 and UCN-01 causes tumor cell death in vivo and prolonged suppression of tumor regrowth.
Journal: Cancer biology & therapy 20051101
Title: Two targets are better than one. Promising combination therapy to treat breast cancer.
Journal: Cancer biology & therapy 20051101
Title: A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines.
Journal: Investigational new drugs 20050801
Title: Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation.
Journal: Cancer research 20050801
Title: Reducing the impact of binding of UCN-01 to human alpha1-acid glycoprotein by encapsulation in liposomes.
Journal: Biological & pharmaceutical bulletin 20050701
Title: The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050615
Title: The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050615
Title: Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.
Journal: Oncogene 20050526
Title: Drugging cell cycle kinases in cancer therapy.
Journal: Current drug targets 20050501
Title: Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
Journal: Cancer research 20050415
Title: Review of UCN-01 development: a lesson in the importance of clinical pharmacology.
Journal: Journal of clinical pharmacology 20050401
Title: Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration.
Journal: Acta pharmacologica Sinica 20050401
Title: RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells.
Journal: Cancer research 20050401
Title: Indifferently pursued or unowned drugs: who should lead where companies do not tread?
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050320
Title: Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050320
Title: Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
Journal: Molecular cancer therapeutics 20050301
Title: Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Journal: Blood 20050215
Title: The mitotic spindle checkpoint is a critical determinant for topoisomerase-based chemotherapy.
Journal: The Journal of biological chemistry 20050211
Title: Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells.
Journal: International journal of oncology 20050201
Title: A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050115
Title: Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein.
Journal: The Journal of biological chemistry 20050114
Title: The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein.
Journal: Oncogene 20050106
Title: Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.
Journal: Cell cycle (Georgetown, Tex.) 20050101
Title: [Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20050101
Title: Blockage of cyclin cdk's, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: evidence for interactive effects of flavopiridol, LY 294002, roscovitine,wortmannin and UCN-01.
Journal: Anticancer research 20050101
Title: Inhibitors of cyclin-dependent kinase modulators for cancer therapy.
Journal: Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 20050101
Title: Enhancement of radiation cytotoxicity by UCN-01 in non-small cell lung carcinoma cells.
Journal: Radiation research 20041201
Title: Chk1 versus Cdc25: chking one's levels of cellular proliferation.
Journal: Cell cycle (Georgetown, Tex.) 20041101
Title: 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041101
Title: Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041015
Title: The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Journal: Molecular cancer therapeutics 20041001
Title: Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Journal: Nucleosides, nucleotides & nucleic acids 20041001
Title: Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
Journal: Journal of experimental therapeutics & oncology 20041001
Title: Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
Journal: Cancer research 20040915
Title: CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Journal: Molecular cancer therapeutics 20040901
Title: Tryptophan residues play an important role in the extraordinarily high affinity binding interaction of UCN-01 to human alpha-1-acid glycoprotein.
Journal: Pharmaceutical research 20040901
Title: UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines.
Journal: Journal of neurochemistry 20040801
Title: In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040801
Title: Time to disease progression to evaluate a novel protein kinase C inhibitor, UCN-01, in renal cell carcinoma.
Journal: Cancer 20040701
Title: Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex.
Journal: The Journal of biological chemistry 20040625
Title: Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040615
Title: Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
Journal: Acta pharmacologica Sinica 20040601
Title: Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.
Journal: Genes & development 20040601
Title: UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway.
Journal: Cancer research 20040515
Title: Metabolism of UCN-01 in isolated perfused rat liver: role of Mrp2 in the biliary excretion of glucuronides.
Journal: Oncology reports 20040501
Title: Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.
Journal: Blood 20040401
Title: Pheophorbide a is a specific probe for ABCG2 function and inhibition.
Journal: Cancer research 20040215
Title: Cell-cycle targeted therapies.
Journal: The Lancet. Oncology 20040101
Title: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
Journal: Molecular pharmacology 20031201
Title: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors.
Journal: European journal of biochemistry 20031201
Title: Induction by staurosporine of hepatocyte growth factor production in human skin fibroblasts independent of protein kinase inhibition.
Journal: Biochemical pharmacology 20031101
Title: Cell cycle modulators for the treatment of lung malignancies.
Journal: Clinical lung cancer 20031101
Title: Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.
Journal: The Biochemical journal 20031015
Title: Induction of colon cancer cell death by 7-hydroxystaurosporine (UCN-01) is associated with increased p38 MAPK and decreased Bcl-xL.
Journal: Anti-cancer drugs 20031001
Title: Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
Journal: Blood 20030901
Title: An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
Journal: The Journal of biological chemistry 20030815
Title: Survival-signaling pathway as a promising target for cancer chemotherapy.
Journal: Cancer chemotherapy and pharmacology 20030701
Title: Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Journal: Cancer chemotherapy and pharmacology 20030701
Title: Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinoma.
Journal: Cancer chemotherapy and pharmacology 20030401
Title: Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.
Journal: The EMBO journal 20030203
Title: Bryostatin 1 and UCN-01 potentiate 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms.
Journal: Molecular pharmacology 20030101
Title: [Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20030101
Title: Potentiation of DNA-damage-induced cytotoxicity by G2 checkpoint abrogators.
Journal: Current medicinal chemistry. Anti-cancer agents 20030101
Title: Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies.
Journal: Current medicinal chemistry. Anti-cancer agents 20030101
Title: Cisplatin-induced ubiquitination of RNA polymerase II large subunit and suppression of induction by 7-hydroxystaurosporine (UCN-01).
Journal: Oncology reports 20030101
Title: Combined antitumor activity of 7-hydroxystaurosporine (UCN-01) and tamoxifen against human breast carcinoma in vitro and in vivo.
Journal: Breast cancer (Tokyo, Japan) 20030101
Title: Structural basis for Chk1 inhibition by UCN-01.
Journal: The Journal of biological chemistry 20021129
Title: Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.
Journal: Blood 20021101
Title: Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021101
Title: UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
Journal: Cancer research 20021015
Title: A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
Journal: Molecular cancer therapeutics 20021001
Title: Cyclin-dependent kinases as new targets for the prevention and treatment of cancer.
Journal: Hematology/oncology clinics of North America 20021001
Title: Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine.
Journal: Molecular pharmacology 20020901
Title: 7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.
Journal: International journal of oncology 20020801
Title: Hematologic malignancies: new developments and future treatments.
Journal: Seminars in oncology 20020801
Title: Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines.
Journal: British journal of cancer 20020729
Title: Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
Journal: The Journal of biological chemistry 20020719
Title: 7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines.
Journal: Radiation research 20020701
Title: 7-Hydroxystaurosporine-induced apoptosis in 9L glioma cells provides an effective antigen source for dendritic cells and yields a potent vaccine strategy in an intracranial glioma model.
Journal: Neurosurgery 20020601
Title: Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma.
Journal: Leukemia & lymphoma 20020401
Title: Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).
Journal: Oncogene 20020307
Title: Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.
Journal: Neoplasia (New York, N.Y.) 20020301
Title: Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.
Journal: Anti-cancer drugs 20020301
Title: Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20020201
Title: UCN-01 (7-hydroxystaurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes.
Journal: Molecular cancer therapeutics 20020201
Title: Protein kinase C inhibitors.
Journal: Current oncology reports 20020101
Title: Influence of G2 arrest on the cytotoxicity of DNA topoisomerase inhibitors toward human carcinoma cells with different p53 status.
Journal: Acta biochimica Polonica 20020101
Title: The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.
Journal: The oncologist 20020101
Title: UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction.
Journal: Breast cancer (Tokyo, Japan) 20020101
Title: Combining phorbol ester (PMA) with UCN-01: fueling fire with water.
Journal: Cell cycle (Georgetown, Tex.) 20020101
Title: UCN-01 (7-hydroxystauorsporine) blocks PMA-induced maturation and reciprocally promotes apoptosis in human myelomonocytic leukemia cells (U937).
Journal: Cell cycle (Georgetown, Tex.) 20020101
Title: Inhibitors of MEK1/2 interact with UCN-01 to induce apoptosis and reduce colony formation in mammary and prostate carcinoma cells.
Journal: Cancer biology & therapy 20020101
Title: CHK and MEK inhibitors team up to trigger cancer cell suicide.
Journal: Cancer biology & therapy 20020101
Title: Independent antitumor spectrum of UCN-01 (7-hydroxystaurosporine) against gastric and colorectal cancers as detected by MTT assay.
Journal: Anticancer research 20020101
Title: Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.
Journal: Cancer biology & therapy 20020101
Title: Beyond directed therapeutics--are two drugs always better than one?
Journal: Cancer biology & therapy 20020101
Title: Development of a simplified, sensitive high-performance liquid chromatographic method using fluorescence detection to determine the concentration of UCN-01 in human plasma.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010905
Title: Blocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanism.
Journal: Neoplasia (New York, N.Y.) 20010901
Title: Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
Journal: Cancer research 20010801
Title: Susceptibility of thyroid cancer cells to 7-hydroxystaurosporine-induced apoptosis correlates with Bcl-2 protein level.
Journal: Thyroid : official journal of the American Thyroid Association 20010801
Title: UCN-01 dose-dependent inhibition of normal hyperproliferative cells in mice.
Journal: International journal of oncology 20010701
Title: Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
Journal: Cancer research 20010701
Title: Protein binding alters the activity of suramin, carboxyamidotriazole, and UCN-01 in an ex vivo rat aortic ring angiogenesis assay.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010701
Title: UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism.
Journal: Experimental hematology 20010601
Title: UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery.
Journal: Japanese journal of cancer research : Gann 20010501
Title: Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010415
Title: Regulation of the G2/M transition by p53.
Journal: Oncogene 20010405
Title: Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.
Journal: Oncogene 20010405
Title: Resistance to growth inhibitory and apoptotic effects of phorbol ester and UCN-01 in aggressive cancer cell lines.
Journal: International journal of oncology 20010401
Title: [CDK inhibitors for therapy of cancer].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20010401
Title: UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010301
Title: S-Phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine.
Journal: Cancer research 20010201
Title: Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010201
Title: UCN-01 Kyowa Hakko Kogyo Co.
Journal: Current opinion in investigational drugs (London, England : 2000) 20010201
Title: Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Journal: The Journal of biological chemistry 20010105
Title: Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
Journal: Leukemia 20010101
Title: Pharmacokinetics, distribution, metabolism and excretion of.
Journal: Cancer chemotherapy and pharmacology 20010101
Title: Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents.
Journal: Anticancer research 20010101
Title: Tissue distribution and plasma pharmacokinetics of UCN-01 at steady-state and following bolus administration in rats: influence of human alpha1-acid glycoprotein binding.
Journal: Anticancer research 20010101
Title: Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
Journal: Blood 20000715
Title: The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.
Journal: Cancer research 20000415
Title: Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines.
Journal: Biochemical pharmacology 19991201
Title: Analogs of staurosporine: potential anticancer drugs?
Journal: General pharmacology 19981101
Title: Activation of PKCalpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia HL60 cells.
Journal: The Journal of biological chemistry 19971212
Title: Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
Journal: Molecular pharmacology 19940601
Title: Comparison of effects of protein kinase C inhibitors on phorbol ester-induced CD4 down-regulation and augmentation of human immunodeficiency virus replication in human T cell lines.
Journal: Biochemical and biophysical research communications 19891016
Title: Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
Journal: Trends in pharmacological sciences 19890601
Title: UCN-01, a selective inhibitor of protein kinase C from Streptomyces.
Journal: The Journal of antibiotics 19871201
Title: Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo). 1989 Apr;42(4):564-70.
Title: Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo). 1989 Apr;42(4):571-6.
