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1216744-19-2,MFCD12027224
Catalog No.:AA009CFD

1216744-19-2 | GSK4112

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Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$11.00   $8.00
- +
5mg
98+%
in stock  
$24.00   $17.00
- +
10mg
98+%
in stock  
$33.00   $23.00
- +
50mg
98+%
in stock  
$109.00   $76.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CFD
Chemical Name:
GSK4112
CAS Number:
1216744-19-2
Molecular Formula:
C18H21ClN2O4S
Molecular Weight:
396.8883
MDL Number:
MFCD12027224
SMILES:
O=C(OC(C)(C)C)CN(Cc1ccc(s1)[N+](=O)[O-])Cc1ccc(cc1)Cl
Properties
Computed Properties
 
Complexity:
487  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
8  
XLogP3:
4.7  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2013,vol.56,#11,p.4729-4737

[1]JournalofMedicinalChemistry,2013,vol.56,#11,p.4729-4737

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists.

Journal: Bioorganic & medicinal chemistry letters 20120601

Title: Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.

Journal: Nature 20120503

Title: Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.

Journal: Biochemical and biophysical research communications 20120406

Title: Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.

Journal: ACS chemical biology 20110218

Title: GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

Journal: ACS chemical biology 20101015

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SDS
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