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1218779-75-9,MFCD22420814
Catalog No.:AA00163W

1218779-75-9 | Apatinib

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00163W
Chemical Name:
Apatinib
CAS Number:
1218779-75-9
Molecular Formula:
C25H27N5O4S
Molecular Weight:
493.5780
MDL Number:
MFCD22420814
SMILES:
CS(=O)(=O)O.N#CC1(CCCC1)c1ccc(cc1)NC(=O)c1cccnc1NCc1ccncc1
Properties
Computed Properties
 
Complexity:
701  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  

Literature

Title: Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo.

Journal: Cancer science 20110701

Title: Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.

Journal: Cancer research 20101015

Title: Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies.

Journal: BMC cancer 20100101

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SDS
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