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122003-11-6,MFCD09750018
Catalog No.:AA009BE9

122003-11-6 | U-83836E

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100mg
≥98%
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$288.00   $202.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA009BE9
Chemical Name:
U-83836E
CAS Number:
122003-11-6
Molecular Formula:
C30H44N6O2
Molecular Weight:
520.7094
MDL Number:
MFCD09750018
SMILES:
Cc1c(C)c2OC(C)(CCc2c(c1O)C)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Properties
Computed Properties
 
Complexity:
783  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.4  

Literature

Title: U83836E inhibits retinal neurodegeneration in early-stage streptozotocin-induced diabetic rats.

Journal: Ophthalmic research 20110101

Title: Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals.

Journal: Journal of neurochemistry 20100701

Title: Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death.

Journal: Journal of neurochemistry 20090101

Title: In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia.

Journal: Neuroscience letters 20061023

Title: Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy.

Journal: Life sciences 20060717

Title: Neuroprotection with methylaminochroman and lazaroid of embryonic ventral mesencephalic tegmental dopaminergic neurons in cold storage.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20060501

Title: Lazaroid U-83836E improves tolerance to hemorrhagic shock and limb ischemia and reperfusion in rats and increases cardiac heat shock protein 72.

Journal: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 20060101

Title: Neonatal alcohol exposure increases malondialdehyde (MDA) and glutathione (GSH) levels in the developing cerebellum.

Journal: Brain research. Developmental brain research 20051207

Title: Antioxidant pretreatment does not ameliorate alcohol-induced Purkinje cell loss in the developing rat cerebellum.

Journal: Alcoholism, clinical and experimental research 20050701

Title: MgSO4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxicity in vitro.

Journal: Acta neurobiologiae experimentalis 20040101

Title: A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation.

Journal: The Journal of biological chemistry 20030516

Title: Lazaroid attenuates edema by stabilizing ATPase in the traumatized rat brain.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20030501

Title: Involvement of the mitochondrial pathway in cold storage and rewarming-associated apoptosis of human renal proximal tubular cells.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20030301

Title: Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants.

Journal: Brain research 20021115

Title: Nitronyl nitroxides, a novel group of protective agents against oxidative stress in endothelial cells forming the blood-brain barrier.

Journal: Neuropharmacology 20021101

Title: Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis.

Journal: Cancer letters 20020328

Title: Effects of antioxidant pretreatment on the survival of embryonic dopaminergic neurons in vitro and following grafting in an animal model of Parkinson's disease.

Journal: Cell transplantation 20020101

Title: Lazaroid compounds prevent early but not late stages of oxidant-induced cell injury: potential explanation for the lack of efficacy of lazaroids in clinical trials.

Journal: Pharmacological research 20010101

Title: Cardiotoxicity of doxorubicin: effects of 21-aminosteroids.

Journal: Life sciences 19980101

Title: Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo.

Journal: Biochemical pharmacology 19960726

Title: Canine in vivo tracheal chemotaxis of eosinophils to antigen in sensitized dogs: inhibition by a steroid, a systemic lazaroid U-78517F, and several topical H1 antihistamines.

Journal: The American review of respiratory disease 19920901

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