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1229208-44-9,MFCD28099806
Catalog No.:AA000JOP

1229208-44-9 | GS-9973

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$66.00   $46.00
- +
10mg
98%
in stock  
$107.00   $75.00
- +
100mg
98%
in stock  
$470.00   $329.00
- +
250mg
98%
in stock  
$884.00   $619.00
- +
1g
98%
in stock  
$2,133.00   $1,493.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000JOP
Chemical Name:
GS-9973
CAS Number:
1229208-44-9
Molecular Formula:
C23H21N7O
Molecular Weight:
411.4591
MDL Number:
MFCD28099806
SMILES:
O1CCN(CC1)c1ccc(cc1)Nc1nc(cn2c1ncc2)c1ccc2c(c1)[nH]nc2
Properties
Computed Properties
 
Complexity:
595  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.6  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2014,vol.57,#9,p.3856-3873

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2014,vol.57,p.3856-3873

75-75-2    1229208-44-9   
6-(1H-indazol-6-yl)-N-4-(4-morpholinyl)phenylimidazo1,2-apyrazin-8-aminedimesylate 

[1]Patent:US2015/38504,2015,A1.Locationinpatent:Paragraph0597-0599

[2]Patent:US2015/38505,2015,A1.Locationinpatent:Paragraph0243-0245

[3]Patent:WO2019/40298,2019,A1.Locationinpatent:Paragraph0193-0197;0199-0205

75-75-2    1229208-44-9   
6-(1H-indazol-6-yl)-N-4-(4-morpholinyl)phenylimidazo1,2-apyrazin-8-aminemesylate 

[1]Patent:US2019/55255,2019,A1.Locationinpatent:Paragraph0145;0146

1229208-44-9    9003-31-0   
CASUnavailable 

[1]Jiang,Wen-Shuang;Ji,Ding-Wei;Zhang,Wei-Song;Zhang,Gong;Min,Xiang-Ting;Hu,Yan-Cheng;Jiang,Xu-Liang;Chen,Qing-An[AngewandteChemie-InternationalEdition,2021,vol.60,#15,p.8321-8328][Angew.Chem.,2021,vol.133,#15,p.8402-8409,8]

Literature

Title: Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

Journal: Journal of medicinal chemistry 20140508

Title: Currie KS, et al. Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase. J Med Chem. 2014 May 8;57(9):3856-73.

Title: Burke RT, et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget. 2014 Feb 28;5(4):908-15.

Quotation Request
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SDS
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Tags:1229208-44-9 Molecular Formula|1229208-44-9 MDL|1229208-44-9 SMILES|1229208-44-9 GS-9973
Catalog No.: AA000JOP
1229208-44-9,MFCD28099806
1229208-44-9 | GS-9973
Pack Size： 1mg
Purity： 99+%
in stock
$15.00 $11.00
Pack Size： 5mg
Purity： 98%
in stock
$66.00 $46.00
Pack Size： 10mg
Purity： 98%
in stock
$107.00 $75.00
Pack Size： 100mg
Purity： 98%
in stock
$470.00 $329.00
Pack Size： 250mg
Purity： 98%
in stock
$884.00 $619.00
Pack Size： 1g
Purity： 98%
in stock
$2,133.00 $1,493.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000JOP
Chemical Name: GS-9973
CAS Number: 1229208-44-9
Molecular Formula: C23H21N7O
Molecular Weight: 411.4591
MDL Number: MFCD28099806
SMILES: O1CCN(CC1)c1ccc(cc1)Nc1nc(cn2c1ncc2)c1ccc2c(c1)[nH]nc2
Properties
Complexity: 595  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.6  
Upstream Synthesis Route
937049-58-6    445263-72-9    1229208-44-9 

[1]JournalofMedicinalChemistry,2014,vol.57,#9,p.3856-3873

Downstream Synthesis Route
937049-58-6    445263-72-9    1229208-44-9 

[1]JournalofMedicinalChemistry,2014,vol.57,p.3856-3873

75-75-2    1229208-44-9   
6-(1H-indazol-6-yl)-N-4-(4-morpholinyl)phenylimidazo1,2-apyrazin-8-aminedimesylate 

[1]Patent:US2015/38504,2015,A1.Locationinpatent:Paragraph0597-0599

[2]Patent:US2015/38505,2015,A1.Locationinpatent:Paragraph0243-0245

[3]Patent:WO2019/40298,2019,A1.Locationinpatent:Paragraph0193-0197;0199-0205

75-75-2    1229208-44-9   
6-(1H-indazol-6-yl)-N-4-(4-morpholinyl)phenylimidazo1,2-apyrazin-8-aminemesylate 

[1]Patent:US2019/55255,2019,A1.Locationinpatent:Paragraph0145;0146

1229208-44-9    9003-31-0   
CASUnavailable 

[1]Jiang,Wen-Shuang;Ji,Ding-Wei;Zhang,Wei-Song;Zhang,Gong;Min,Xiang-Ting;Hu,Yan-Cheng;Jiang,Xu-Liang;Chen,Qing-An[AngewandteChemie-InternationalEdition,2021,vol.60,#15,p.8321-8328][Angew.Chem.,2021,vol.133,#15,p.8402-8409,8]

Literature fold

Title: Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.

Journal: Journal of medicinal chemistry20140508

Title: Currie KS, et al. Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase. J Med Chem. 2014 May 8;57(9):3856-73.

Title: Burke RT, et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget. 2014 Feb 28;5(4):908-15.

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