Home Amines 1232030-35-1
1232030-35-1,MFCD26793866
Catalog No.:AA000K33

1232030-35-1 | Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]aMino]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$52.00   $36.00
- +
5mg
≥98%
in stock  
$150.00   $105.00
- +
10mg
≥98%
in stock  
$269.00   $188.00
- +
25mg
in stock  
$429.00   $300.00
- +
50mg
96%
in stock  
$834.00   $584.00
- +
100mg
in stock  
$1,029.00   $720.00
- +
250mg
96%
in stock  
$2,422.00   $1,695.00
- +
1000mg
99% (HPLC)
in stock  
$8,787.00   $6,151.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000K33
Chemical Name:
Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]aMino]-
CAS Number:
1232030-35-1
Molecular Formula:
C25H23Cl2FN6O
Molecular Weight:
513.3941
MDL Number:
MFCD26793866
SMILES:
CCn1c2nc(ncc2cc(c1=O)c1ccc(cc1Cl)Cl)Nc1ccc(c(c1)F)N1CCNCC1
Properties
Computed Properties
 
Complexity:
783  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.8  

Downstream Synthesis Route
Literature

Title: Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.

Journal: ACS medicinal chemistry letters 20150709

Title: PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20140429

Title: Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20130402

Title: Wang Y, et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS One. 2016 Apr 12;11(4):e0153312.

Title: Hayashi-Takagi A, et al. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6461-6.

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SDS
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Tags:1232030-35-1 Molecular Formula|1232030-35-1 MDL|1232030-35-1 SMILES|1232030-35-1 Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,4-dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]aMino]-