Catalog No.:AA000KHH

1234356-69-4 | Derazantinib

Name: Name:Derazantinib
Brand: AABLOCKS
SKU: AA000KHH
Availability: InStock
Rating: 90 (10 reviews)

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Purity

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Quantity

1mg

99+%

in stock

$31.00 $22.00

- +

5mg

99+%

in stock

$76.00 $54.00

- +

25mg

99+%

in stock

$197.00 $138.00

- +

Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA000KHH

Chemical Name:

Derazantinib

CAS Number:

1234356-69-4

Molecular Formula:

C29H29FN4O

Molecular Weight:

468.5652

MDL Number:

MFCD30532770

SMILES:

COCCNCCc1cccc(c1)Nc1ncc2c(n1)c1ccccc1[C@@H](C2)c1ccccc1F

Properties

Computed Properties

Complexity:

638

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

5.3

Literature

Title: A Phase 1 study of ARQ 087, an oral pan-FGFR inhibitor in patients with advanced solid tumours.

Journal: British journal of cancer 20171121

Title: Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation.

Journal: PloS one 20160101

Title: Hall TG, et al. Preclinical Activity of ARQ-087, a Novel Inhibitor Targeting FGFR Dysregulation. PLoS One. 2016 Sep 14;11(9):e0162594.

Title: Balek L, et al. ARQ-087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3. Bone. 2017 Dec;105:57-66.

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SDS