[1]JournalofMedicinalChemistry,1992,vol.35,p.223-233
[2]Patent:WO2016/144905,2016,A1.Locationinpatent:Paragraph0156
[1]Synthesis,1992,p.741-743
[1]JournalofMedicinalChemistry,1992,vol.35,p.223-233
[1]JournalofMedicinalChemistry,1997,vol.40,p.3100-3108
[2]BioorganicandMedicinalChemistryLetters,2005,vol.15,p.599-602
[3]Organicprocessresearchanddevelopment,2011,vol.15,p.1124-1129
[1]BioorganicandMedicinalChemistryLetters,2005,vol.15,p.599-602
Title: Characterization of antinociceptive potency of endomorphin-2 derivatives with unnatural amino acids in rats.
Journal: Acta physiologica Hungarica 20120901
Title: Bifunctional μ/δ opioid peptides: variation of the type and length of the linker connecting the two components.
Journal: Chemical biology & drug design 20120201
Title: In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera.
Journal: Molecular brain 20120101
Title: Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation.
Journal: PloS one 20120101
Title: Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.
Journal: Bioorganic & medicinal chemistry 20111201
Title: Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Journal: Journal of medicinal chemistry 20110414
Title: Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.
Journal: Bioorganic & medicinal chemistry 20100815
Title: N-methylated cyclic enkephalin analogues retain high opioid receptor binding affinity.
Journal: Chemical biology & drug design 20100201
Title: Delta opioid receptor on equine sperm cells: subcellular localization and involvement in sperm motility analyzed by computer assisted sperm analyzer (CASA).
Journal: Reproductive biology and endocrinology : RB&E 20100101
Title: Cyclic opioid peptide agonists and antagonists obtained via ring-closing metathesis.
Journal: Chemical biology & drug design 20091001
Title: [Overview in 45 years of studies on peptide chemistry].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20091001
Title: Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.
Journal: Bioorganic & medicinal chemistry 20090601
Title: Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp].
Journal: Journal of medicinal chemistry 20080925
Title: Conformation-activity relationships of cyclo-constrained micro/delta opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20080801
Title: Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides.
Journal: Bioorganic & medicinal chemistry 20080601
Title: Targeting mitochondria.
Journal: Accounts of chemical research 20080101
Title: Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
Journal: Bioorganic & medicinal chemistry letters 20071101
Title: [N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.
Journal: The Journal of pharmacology and experimental therapeutics 20071001
Title: Novel diastereomeric opioid tetrapeptides exhibit differing pharmacological activity profiles.
Journal: Brain research bulletin 20070914
Title: Bioactivity of new mu and delta opioid peptides.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20070901
Title: Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.
Journal: Journal of medicinal chemistry 20070614
Title: Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide.
Journal: Bioorganic & medicinal chemistry letters 20070401
Title: Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).
Journal: Journal of medicinal chemistry 20070208
Title: Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.
Journal: Journal of medicinal chemistry 20060824
Title: New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Journal: Journal of medicinal chemistry 20060629
Title: Novel 99mTc-labeled neurotensin analogues with optimized biodistribution properties.
Journal: Journal of medicinal chemistry 20060309
Title: Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines.
Journal: Biochemical pharmacology 20051205
Title: Opioid peptide-derived analgesics.
Journal: The AAPS journal 20050901
Title: Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy.
Journal: The journal of peptide research : official journal of the American Peptide Society 20050601
Title: A new structural motif for mu-opioid antagonists.
Journal: Journal of medicinal chemistry 20050519
Title: Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
Journal: Bioorganic & medicinal chemistry letters 20050201
Title: Fluorescent dyes alter intracellular targeting and function of cell-penetrating tetrapeptides.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050101
Title: Opioid receptor binding characteristics and structure-activity studies of novel tetrapeptides in the TIPP (Tyr-Tic-Phe-Phe) series.
Journal: Neuro-Signals 20050101
Title: Tolerance develops in spinal cord, but not in brain with chronic [Dmt1]DALDA treatment.
Journal: British journal of pharmacology 20041201
Title: Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury.
Journal: The Journal of biological chemistry 20040813
Title: Quantitative analysis of [Dmt(1)]DALDA in ovine plasma by capillary liquid chromatography-nanospray ion-trap mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040415
Title: Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20040401
Title: 2',6'-dimethylphenylalanine (Dmp) can mimic the N-terminal Tyr in opioid peptides.
Journal: Biological & pharmaceutical bulletin 20040201
Title: Dansylated analogues of the opioid peptide [Dmt1]DALDA: in vitro activity profiles and fluorescence parameters.
Journal: Acta biochimica Polonica 20040101
Title: Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at mu, delta, and kappa opioid receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20031201
Title: Characterization of the binding of [3H][Dmt1]H-Dmt-D-Arg-Phe-Lys-NH2, a highly potent opioid peptide.
Journal: The Journal of pharmacology and experimental therapeutics 20030801
Title: Highly potent fluorescent analogues of the opioid peptide [Dmt1] DALDA.
Journal: Peptides 20030801
Title: Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA.
Journal: The Journal of pharmacology and experimental therapeutics 20030501
Title: Structural studies of [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond.
Journal: Bioorganic & medicinal chemistry 20030501
Title: 2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists.
Journal: Journal of medicinal chemistry 20030227
Title: Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide.
Journal: The Journal of pharmacology and experimental therapeutics 20030101
Title: Quantification of [Dmt1]DALDA in ovine plasma by on-line liquid chromatography/quadrupole time-of-flight mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20030101
Title: Dmt and opioid peptides: a potent alliance.
Journal: Biopolymers 20030101
Title: [2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.
Journal: Journal of medicinal chemistry 20010913
Title: Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
Journal: Journal of medicinal chemistry 20010719
Title: Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20010701
Title: Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1] DALDA.
Journal: The Journal of pharmacology and experimental therapeutics 20010401
