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Home Other Building Blocks 1239358-85-0
1239358-85-0,MFCD29472295
Catalog No.:AA009CIB

1239358-85-0 | NS-018 hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$165.00   $116.00
- +
5mg
95%
1 week  
$324.00   $227.00
- +
10mg
95%
1 week  
$430.00   $301.00
- +
25mg
95%
1 week  
$604.00   $423.00
- +
50mg
95%
1 week  
$844.00   $591.00
- +
100mg
95%
1 week  
$1,186.00   $830.00
- +
500mg
95%
1 week  
$2,320.00   $1,624.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CIB
Chemical Name:
NS-018 hydrochloride
CAS Number:
1239358-85-0
Molecular Formula:
C21H21ClFN7
Molecular Weight:
425.8897
MDL Number:
MFCD29472295
SMILES:
Fc1ccc(cc1)[C@@H](Nc1nc(Nc2cnccn2)cc(c1)c1cnn(c1)C)C.Cl
Properties
Computed Properties
 
Complexity:
501  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  

Literature

Title: Nakaya Y, et al. Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms. Blood Cancer J. 2011 Jul;1(7):e29.

Title: Kuroda J, et al. NS-018, a selective JAK2 inhibitor, preferentially inhibits CFU-GM colony formation by bone marrow mononuclear cells from high-risk myelodysplastic syndrome patients. Leuk Res. 2014 May;38(5):619-24.

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SDS
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Tags:1239358-85-0 Molecular Formula|1239358-85-0 MDL|1239358-85-0 SMILES|1239358-85-0 NS-018 hydrochloride