Home Amines 1255580-76-7
1255580-76-7,MFCD17215972
Catalog No.:AA000NS4

1255580-76-7 | 4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-

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1mg
98%
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$15.00   $11.00
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10mg
98%
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$53.00   $37.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000NS4
Chemical Name:
4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
CAS Number:
1255580-76-7
Molecular Formula:
C30H47N5O2
Molecular Weight:
509.7265
MDL Number:
MFCD17215972
SMILES:
COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)C1CCCCC1
Properties
Computed Properties
 
Complexity:
660  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
10  
XLogP3:
6.3  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2011,vol.54,#17,p.6139-6150

[1]JournalofMedicinalChemistry,2011,vol.54,#17,p.6139-6150

[1]JournalofMedicinalChemistry,2011,vol.54,#17,p.6139-6150

[1]JournalofMedicinalChemistry,2011,vol.54,#17,p.6139-6150

[1]JournalofMedicinalChemistry,2011,vol.54,#17,p.6139-6150

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2011,vol.54,p.6139-6150

Literature

Title: Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20160101

Title: Effects of the histone methyltransferase inhibitor UNC0638 on histone H3K9 dimethylation of cultured ovine somatic cells and development of resulting early cloned embryos.

Journal: Reproduction in domestic animals = Zuchthygiene 20140401

Title: Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.

Journal: ACS medicinal chemistry letters 20140213

Title: Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatment.

Journal: PloS one 20140101

Title: Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

Journal: Journal of medicinal chemistry 20131114

Title: Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.

Journal: Cell death & disease 20130201

Title: Oncoepigenomics: making histone lysine methylation count.

Journal: European journal of medicinal chemistry 20121001

Title: Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

Journal: Journal of medicinal chemistry 20110908

Title: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Journal: Nature chemical biology 20110710

Title: Vedadi M, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74.

Title: Fu L, et al. Effects of the Histone Methyltransferase Inhibitor UNC0638 on Histone H3K9 Dimethylation of Cultured Ovine Somatic Cells and Development of Resulting Early Cloned Embryos. Reprod Domest Anim. 2014 Apr;49(2):e21-5.

Title: Singh N, et al. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. J Interferon Cytokine Res. 2016 Jan;36(1):37-47.

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Tags:1255580-76-7 Molecular Formula|1255580-76-7 MDL|1255580-76-7 SMILES|1255580-76-7 4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-