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1256388-51-8,MFCD25976756
Catalog No.:AA00HIA9

1256388-51-8 | ledipasvir

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Purity
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Price(USD)
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5mg
98%
in stock  
$6.00   $4.00
- +
10mg
98%
in stock  
$8.00   $6.00
- +
25mg
98%
in stock  
$11.00   $8.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HIA9
Chemical Name:
ledipasvir
CAS Number:
1256388-51-8
Molecular Formula:
C49H54F2N8O6
Molecular Weight:
888.9999
MDL Number:
MFCD25976756
SMILES:
COC(=O)N[C@H](C(=O)N1CC2(C[C@H]1c1ncc([nH]1)c1ccc3c(c1)C(F)(F)c1c3ccc(c1)c1ccc3c(c1)[nH]c(n3)[C@@H]1[C@H]3CC[C@@H](N1C(=O)[C@H](C(C)C)NC(=O)OC)C3)CC2)C(C)C
Properties
Computed Properties
 
Complexity:
1820  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
65  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
12  
XLogP3:
7.4  

Downstream Synthesis Route

[1]Patent:WO2013/40492,2013,A2.Locationinpatent:Page/Pagecolumn85

[1]Patent:WO2017/145028,2017,A1

[2]Patent:WO2013/40492,2013,A2

[1]Patent:US2013/273005,2013,A1

[2]Patent:WO2013/40492,2013,A2

[1]Patent:US2013/273005,2013,A1

[2]Patent:US2018/79744,2018,A1

[3]Patent:WO2013/40492,2013,A2

C35H32F2N6*4ClH 
  1256388-51-8 

[1]Patent:US2013/324496,2013,A1

Literature

Title: Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

Journal: Drugs 20170701

Title: Interferon-free therapy for hepatitis C: The hurdles amid a golden era.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20150901

Title: Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1.

Journal: The New England journal of medicine 20150820

Title: Treatment with ledipasvir and sofosbuvir improves patient-reported outcomes: Results from the ION-1, -2, and -3 clinical trials.

Journal: Hepatology (Baltimore, Md.) 20150601

Title: Fixed-dose combination of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C genotype 1.

Journal: Expert opinion on pharmacotherapy 20150401

Title: Ledipasvir/Sofosbuvir: a review of its use in chronic hepatitis C.

Journal: Drugs 20150401

Title: Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection.

Journal: JAMA 20150301

Title: Ledipasvir and sofosbuvir: Interferon free therapy for hepatitis C virus genotype 1 infection.

Journal: World journal of virology 20150212

Title: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Journal: Canadian journal of gastroenterology & hepatology 20150101

Title: Changing the face of hepatitis C management - the design and development of sofosbuvir.

Journal: Drug design, development and therapy 20150101

Title: Ledipasvir : a novel synthetic antiviral for the treatment of HCV infection.

Journal: Expert opinion on investigational drugs 20140401

Title: Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.

Journal: Journal of medicinal chemistry 20140313

Title: Preclinical characterization of the novel hepatitis C virus NS3 protease inhibitor GS-9451.

Journal: Antimicrobial agents and chemotherapy 20140201

Title: Side effects of alpha interferon in chronic hepatitis C.

Journal: Hepatology (Baltimore, Md.) 19970901

Title: Link JO, et al. Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46

Title: Hernandez D, et al. Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors. J Clin Virol. 2013 May;57(1):13-8.

Title: Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.

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SDS
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