Home Amines 126456-43-7
126456-43-7,MFCD00216655
Catalog No.:AA0072O0

126456-43-7 | (1S,2R)-(-)-Cis-1-amino-2-indanol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$7.00   $5.00
- +
10g
98%
in stock  
$13.00   $9.00
- +
25g
98%
in stock  
$19.00   $14.00
- +
100g
98%
in stock  
$73.00   $51.00
- +
500g
98%
in stock  
$357.00   $250.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0072O0
Chemical Name:
(1S,2R)-(-)-Cis-1-amino-2-indanol
CAS Number:
126456-43-7
Molecular Formula:
C9H11NO
Molecular Weight:
149.1897
MDL Number:
MFCD00216655
SMILES:
N[C@@H]1[C@H](O)Cc2c1cccc2
Properties
Computed Properties
 
Complexity:
149  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
0.2  

Downstream Synthesis Route

[1]Ghosh;Fidanze[JournalofOrganicChemistry,1998,vol.63,#18,p.6146-6152]

[2]Ghosh;Ghosh,ArunK.;Chen;Yan,Chen[TetrahedronLetters,1995,vol.36,#38,p.6811-6814]

[3]Ghosh,ArunK.;Bischoff,Alexander;Cappiello,John[EuropeanJournalofOrganicChemistry,2003,#5,p.821-832]

[4]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-US2005/209488,2005,A1Locationinpatent:Page/Pagecolumn7-8

[5]Bandini,Marco;Monari,Magda;Romaniello,Alessandro;Tragni,Michele[Chemistry-AEuropeanJournal,2010,vol.16,#48,p.14272-14277]

[1]Guo,Rongwei;Lu,Shuiming;Chen,Xuanhua;Tsang,Chi-Wing;Jia,Wenli;Sui-Seng,Christine;Amoroso,Dino;Abdur-Rashid,Kamaluddin[JournalofOrganicChemistry,2010,vol.75,#3,p.937-940]

[2]Gao,Yaojun;Ren,Qiao;Wu,Hao;Li,Maoguo;Wang,Jian[ChemicalCommunications,2010,vol.46,#48,p.9232-9234]Ren,Qiao;Gao,Yaojun;Wang,Jian[Chemistry-AEuropeanJournal,2010,vol.16,#46,p.13594-13598]

[3]CurrentPatentAssignee:CHIDALATREATCOMPANIES;CIDARATHERAPEUTICSINC-WO2020/252393,2020,A1Locationinpatent:Page/Pagecolumn327

[4]Bit,Christelle;Mitrochkine,AntonA.;Gil,Gerard;Pierrot,Marcel;Reglier,Marius[TetrahedronAsymmetry,1998,vol.9,#18,p.3263-3273]

[5]Qiao,JenniferX.;Wang,TammyC.;Wang,GrenZ.;Cheney,DanielL.;He,Kan;Rendina,AlanR.;Xin,Baomin;Luettgen,JosephM.;Knabb,RobertM.;Wexler,RuthR.;Lam,PatrickY.S.[BioorganicandMedicinalChemistryLetters,2007,vol.17,#18,p.5041-5048]

[6]Gardelli,Cristina;Wada,Hiroki;Ray,Asim;Caffrey,Moya;Llinas,Antonio;Shamovsky,Igor;Tholander,Joakim;Larsson,Joakim;Sivars,Ulf;Hultin,Leif;Andersson,Ulf;Sanganee,HiteshJ.;Stenvall,Kristina;Leidvik,Brith;Gedda,Karin;Jinton,Lisa;RydénLandergren,Marie;Karabelas,Kostas[JournalofMedicinalChemistry,2018,vol.61,#14,p.5974-5987]

[7]CurrentPatentAssignee:SYROSPHARMACEUTICALSINC-WO2019/143730,2019,A1Locationinpatent:Paragraph116

[8]Dinh,AndrewN.;Maddox,SeanM.;Vaidya,SagarD.;Saputra,MirzaA.;Nalbandian,ChristopherJ.;Gustafson,JeffreyL.[JournalofOrganicChemistry,2020,vol.85,#21,p.13895-13905]

[1]TetrahedronLetters,2005,vol.46,p.4543-4546

7321-55-3    126456-43-7   
CASUnavailable 
  175166-51-5    220886-58-8 

[1]Garcia,JoseI.;Mayoral,JoseA.;Pires,Elisabet;Villalba,Isabel[TetrahedronAsymmetry,2006,vol.17,#15,p.2270-2275]

[1]Kurosu,Michio;Porter,JamesR.;Foley,MichaelA.[TetrahedronLetters,2004,vol.45,#1,p.145-148]

[2]Guan,Yong;Attard,JonathanW.;Mattson,AnitaE.[Chemistry-AEuropeanJournal,2020,vol.26,#8,p.1742-1747]

Literature

Title: Enantioselective acylation of 1,2- and 1,3-diols catalyzed by aminophosphinite derivatives of (1S,2R)-1-amino-2-indanol.

Journal: Organic letters 20120203

Title: Synthesis of enantiomerically pure trans-(1R,2R)- and cis-(1S,2R)-1-amino-2-indanol by lipase and omega-transaminase.

Journal: Biotechnology and bioengineering 20060205

Title: Potent P1' biphenylmethyl substituted aggrecanase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20020107

Title: Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.

Journal: Journal of medicinal chemistry 20011011

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:126456-43-7 Molecular Formula|126456-43-7 MDL|126456-43-7 SMILES|126456-43-7 (1S,2R)-(-)-Cis-1-amino-2-indanol |Organic_Building_Blocks