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127-07-1,MFCD00007943
Catalog No.:AA000WFR

127-07-1 | Hydroxyurea

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10g
97%
in stock  
$6.00   $4.00
- +
25g
97%
in stock  
$13.00   $9.00
- +
100g
97%
in stock  
$39.00   $28.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000WFR
Chemical Name:
Hydroxyurea
CAS Number:
127-07-1
Molecular Formula:
CH4N2O2
Molecular Weight:
76.0547
MDL Number:
MFCD00007943
SMILES:
NC(=O)NO
UN Number:
2811
Properties
Properties
 
BP:
136.04°C (rough estimate)  
Form:
Solid  
MP:
135 °C  
Refractive Index:
1.4840 (estimate)  
Solubility:
H2O: 50 mg/mL  
Storage:
Room Temperature;Light sensitive;Inert atmosphere;  

Computed Properties
 
Complexity:
42.9  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
5  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
XLogP3:
-1.8  

Literature

Title: Kovacic P, et al. Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76(1):24-31.

Title: Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33(12):1486-92.

Title: Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7.

Title: Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95(9):1599-603.

Title: M B Slabaugh, et al. Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase. J Virol. 1986 Nov;60(2):506-14.

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