Home Other Building Blocks 1271022-90-2
1271022-90-2,MFCD22200575
Catalog No.:AA000WL1

1271022-90-2 | Bms-911543

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$89.00   $62.00
- +
5mg
98%
in stock  
$148.00   $104.00
- +
25mg
98%
in stock  
$466.00   $326.00
- +
100mg
98%
in stock  
$1,378.00   $965.00
- +
1000mg
99% (HPLC)
in stock  
$11,279.00   $7,896.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000WL1
Chemical Name:
Bms-911543
CAS Number:
1271022-90-2
Molecular Formula:
C23H28N8O
Molecular Weight:
432.5214
MDL Number:
MFCD22200575
SMILES:
CCn1c(cc2c1nc(Nc1nn(c(c1)C)C)c1c2n(C)cn1)C(=O)N(C1CC1)C1CC1
Properties
Computed Properties
 
Complexity:
717  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
2.9  

Literature

Title: Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2.

Journal: Leukemia 20120201

Title: Wan H, et al. Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms. ACS Med Chem Lett. 2015 Jul 12;6(8):850-5.

Title: Mace TA, et al. Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer. Oncotarget. 2015 Dec 29;6(42):44509-22.

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SDS
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