Home Amines 127910-31-0
127910-31-0,MFCD00153906
Catalog No.:AA000H5K

127910-31-0 | 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
95%
in stock  
$266.00   $186.00
- +
50mg
95%
in stock  
$463.00   $324.00
- +
100mg
95%
in stock  
$793.00   $555.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000H5K
Chemical Name:
3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-
CAS Number:
127910-31-0
Molecular Formula:
C6H12NO5P
Molecular Weight:
209.1369
MDL Number:
MFCD00153906
SMILES:
C/C(=C\C(C(=O)O)N)/CP(=O)(O)O
Properties
Properties
 
Form:
Solid  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
268  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-4.1  

Literature

Title: Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-methyl-D-aspartate receptor signaling.

Journal: Biological psychiatry 20110601

Title: Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

Title: Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1.

Journal: Neuroscience letters 20100802

Title: Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20081101

Title: Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia.

Journal: Neuroscience 20080602

Title: NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice.

Journal: Pharmacological reports : PR 20080101

Title: Detrimental effect of postnatal blockade of N-methyl-D-aspartate receptors on sensorimotor gating is reversed by neuroleptic drugs.

Journal: Pharmacological reports : PR 20080101

Title: NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice.

Journal: Pharmacology, biochemistry, and behavior 20071201

Title: Enhanced glutamatergic transmission reduces the anticonvulsant potential of lamotrigine but not of felbamate against tonic-clonic seizures.

Journal: Pharmacological reports : PR 20070101

Title: Activation of the NMDA/glutamate receptor complex antagonizes the NMDA antagonist-induced antidepressant-like effects in the forced swim test.

Journal: Pharmacological reports : PR 20070101

Title: Alterations in the dendritic morphology of prefrontal pyramidal neurons in adult rats after blockade of NMDA receptors in the postnatal period.

Journal: Brain research 20051116

Title: Development of a three-dimensional model for the N-methyl-D-aspartate NR2A subunit.

Journal: Journal of medicinal chemistry 20050825

Title: Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice.

Journal: Synapse (New York, N.Y.) 20050615

Title: Blockade of NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050601

Title: Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.

Journal: European journal of pharmacology 20050523

Title: GSA: behavioral, histological, electrophysiological and neurochemical effects.

Journal: Physiology & behavior 20050215

Title: Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat.

Journal: Basic & clinical pharmacology & toxicology 20040301

Title: Competitive NMDA receptor antagonists and agonists: effects on spontaneous alternation in mice exposed to cerebral oligemia.

Journal: Polish journal of pharmacology 20040101

Title: Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.

Journal: Kidney international 20030501

Title: Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study.

Journal: Neuroscience 20030101

Title: A competitive antagonist of NMDA receptors CGP 40116 attenuates experimental symptoms of schizophrenia evoked by MK-801.

Journal: Polish journal of pharmacology 20030101

Title: NMDA receptor antagonists impair motor performance in immature rats.

Journal: Psychopharmacology 20020801

Title: Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.

Journal: Neuroscience 20010101

Title: Repeated imipramine administration enhances the effects of NMDA receptor ligands on synchronous activity in rat frontal cortex in vitro.

Journal: Polish journal of pharmacology 20010101

Title: Morphine-induced catalepsy is augmented by NMDA receptor antagonists, but is partially attenuated by an AMPA receptor antagonist.

Journal: European journal of pharmacology 19960111

Title: The AMPA receptor antagonist GYKI 52466 reverses the anti-cataleptic effects of the competitive NMDA receptor antagonist CGP 37849.

Journal: European journal of pharmacology 19940502

Title: The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse.

Journal: Pharmacology, biochemistry, and behavior 19940101

Title: Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.

Journal: European journal of pharmacology 19930406

Title: Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.

Journal: Journal of neural transmission. Parkinson's disease and dementia section 19930101

Title: Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity.

Journal: Polish journal of pharmacology 19930101

Title: Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex.

Journal: Polish journal of pharmacology 19930101

Title: Fagg GE, et al. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. Br J Pharmacol. 1990 Apr;99(4):791-7.

Title: Schmutz M, et al. The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342(1):61-6.

Title: Papp M, et al. Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression. Eur J Pharmacol. 1994 Sep 22;263(1-2):1-7.

Title: Przegaliński E, et al. The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats. Neuropharmacology. 2000 Jul 24;39(10):1858-64.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 127910-31-0
Tags:127910-31-0 Molecular Formula|127910-31-0 MDL|127910-31-0 SMILES|127910-31-0 3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-