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128-57-4,MFCD00151528
Catalog No.:AA000XL1

128-57-4 | Sennoside b

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1mg
95%
in stock  
$14.00   $10.00
- +
5mg
≥98%
in stock  
$52.00   $36.00
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10mg
≥98%
in stock  
$90.00   $63.00
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25mg
≥98%
in stock  
$172.00   $120.00
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50mg
≥98%
in stock  
$269.00   $188.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000XL1
Chemical Name:
Sennoside b
CAS Number:
128-57-4
Molecular Formula:
C42H38O20
Molecular Weight:
862.7391
MDL Number:
MFCD00151528
SMILES:
OC[C@H]1O[C@@H](Oc2cccc3c2C(=O)c2c([C@@H]3[C@@H]3c4cc(cc(c4C(=O)c4c3cccc4O[C@@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)O)C(=O)O)cc(cc2O)C(=O)O)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1550  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Heavy Atom Count:
62  
Hydrogen Bond Acceptor Count:
20  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
9  
XLogP3:
1.2  

Downstream Synthesis Route
128-57-4    517-44-2   
sennidin-B-8-monoglucoside 
 
sennidin-B-8'-monoglucoside 
 
sennidinA 

[1]Hattori;Kim;Motoike;Kobashi;Namba[ChemicalandPharmaceuticalBulletin,1982,vol.30,#4,p.1338-1346]

Literature

Title: Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20161115

Title: Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract.

Journal: Journal of ethnopharmacology 20140227

Title: Chemical-based species classification of rhubarb using simultaneous determination of five bioactive substances by HPLC and LDA analysis.

Journal: Phytochemical analysis : PCA 20120101

Title: Promotion of intestinal peristalsis by Bifidobacterium spp. capable of hydrolysing sennosides in mice.

Journal: PloS one 20120101

Title: Effects of optimized-SopungSunkiwon on memory impairment and enhancement.

Journal: Neuroscience letters 20110317

Title: The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice.

Journal: Biological & pharmaceutical bulletin 20110101

Title: High-performance liquid chromatographic determination and metabolic study of sennoside a in daiokanzoto by mouse intestinal bacteria.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Simple and rapid analysis of sennoside A and sennoside B contained in crude drugs and crude drug products by solid-phase extraction and high-performance liquid chromatography.

Journal: Journal of natural medicines 20100401

Title: Stimulatory action of mitemcinal (GM-611), an acid-resistant non-peptide motilin receptor agonist, on colonic motor activity and defecation: spontaneous and mitemcinal-induced giant migrating contractions during defecation in dogs.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20091001

Title: Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells.

Journal: Life sciences 20090619

Title: Development of eastern blotting technique for sennoside A and sennoside B using anti-sennoside A and anti-sennoside B monoclonal antibodies.

Journal: Phytochemical analysis : PCA 20090101

Title: Transport of sennosides and sennidines from Cassia angustifolia and Cassia senna across Caco-2 monolayers--an in vitro model for intestinal absorption.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080501

Title: A comparison of sennosides-based bowel protocols with and without docusate in hospitalized patients with cancer.

Journal: Journal of palliative medicine 20080501

Title: [Determination of five primary chemical constituents in Cassia angustifolia by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

Title: The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080101

Title: Efficacy of prokinetic agents in improving bowel preparation for colonoscopy.

Journal: Digestion 20080101

Title: Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2).

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070401

Title: Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis.

Journal: Journal of chromatography. A 20070323

Title: Safety and efficacy of NT, an herbal supplement, in treating human obesity.

Journal: International journal of obesity (2005) 20061201

Title: [Comparative studies on purgative potency among three spieces of certified rhubarb].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Title: Determination of 19 rhubarb constituents by high-performance liquid chromatography-ultraviolet-mass spectrometry.

Journal: Journal of separation science 20061101

Title: Insulin sensitizing and alpha-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma.

Journal: Life sciences 20060125

Title: Sennosides A and B production by hairy roots of Senna alata (L.) Roxb.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

Title: Liquid chromatographic determination of sennosides in Cassia angustifolia leaves.

Journal: Journal of AOAC International 20060101

Title: The bowel cleansing for colonoscopy. A randomized trial comparing three methods.

Journal: Annali italiani di chirurgia 20060101

Title: The influence of the sennosides on absorption of glycyrrhetic acid in rats.

Journal: Biological & pharmaceutical bulletin 20051001

Title: Advice needed.

Journal: Australian nursing journal (July 1993) 20050901

Title: Simultaneous determination of anthraquinones, their 8-beta-D-glucosides, and sennosides of Rhei Rhizoma by capillary electrophoresis.

Journal: Chemical & pharmaceutical bulletin 20050501

Title: Compatibility of sennoside A and B with pharmaceutical excipients.

Journal: Die Pharmazie 20040901

Title: [Development of rapid and sensitive screening methods for natural products using specific monoclonal antibodies].

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20040801

Title: [Determination of sennosides and degraded products in the process of sennoside metabolism by HPLC].

Journal: Se pu = Chinese journal of chromatography 20040101

Title: [Comparison of the effectiveness and tolerability of the saccharosum-sennosid-B solution and sodium-picosulfate in preparation for colonoscopy. Prospective, multicenter, randomized study].

Journal: Orvosi hetilap 20030810

Title: Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.

Journal: Journal of natural products 20021101

Title: Validated HPLC method for determination of sennosides A and B in senna tablets.

Journal: Journal of pharmaceutical and biomedical analysis 20020731

Title: Production of monoclonal antibodies against a major purgative component, sennoside B, their characterization and use in ELISA.

Journal: The Analyst 20010801

Title: Potassium supplements prevent serious hypokalaemia in colon cleansing.

Journal: Clinical radiology 19941201

Title: The metabolism of sennosides A and B by the intestinal microflora: in vitro and in vivo studies on the rat and the mouse.

Journal: The Journal of pharmacy and pharmacology 19811001

Title: Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422.

Title: Chen YC, et al. Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. Life Sci. 2009 Jun 19;84(25-26):915-22.

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