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Home Amines 1282041-94-4
1282041-94-4,MFCD28502125
Catalog No.:AA000XS1

1282041-94-4 | Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-, (OC-6-21)-

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$189.00   $132.00
- +
10mg
≥98%
in stock  
$346.00   $242.00
- +
25mg
≥98%
in stock  
$783.00   $548.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000XS1
Chemical Name:
Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-, (OC-6-21)-
CAS Number:
1282041-94-4
Molecular Formula:
C14H12F7N5S
Molecular Weight:
415.3324
MDL Number:
MFCD28502125
SMILES:
Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2c(n1)nc(n2)C(F)(F)C
Properties
Computed Properties
 
Complexity:
566  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
6.5  

Literature

Title: Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study.

Journal: The Lancet. Infectious diseases 20180801

Title: Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.

Journal: The Lancet. Infectious diseases 20170601

Title: DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection.

Journal: The Lancet. Infectious diseases 20170601

Title: A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Journal: Science translational medicine 20150715

Title: Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.

Title: Phillips MA, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med. 2015 Jul 15;7(296):296ra111.

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SDS
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Tags:1282041-94-4 Molecular Formula|1282041-94-4 MDL|1282041-94-4 SMILES|1282041-94-4 Sulfur, [4-[[2-(1,1-difluoroethyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]pentafluoro-, (OC-6-21)-