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129-49-7,MFCD00083185
Catalog No.:AA01CCFN

129-49-7 | Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8b)-,(2Z)-2-butenedioate (1:1) (salt)

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1mg
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5mg
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$156.00   $109.00
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10mg
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CCFN
Chemical Name:
Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8b)-,(2Z)-2-butenedioate (1:1) (salt)
CAS Number:
129-49-7
Molecular Formula:
C25H31N3O6
Molecular Weight:
469.5301
MDL Number:
MFCD00083185
SMILES:
OC(=O)/C=C\C(=O)O.CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO
NSC Number:
759143
Properties
Computed Properties
 
Complexity:
697  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  

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Title: Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.

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Journal: Psychopharmacology 20021201

Title: Inhibition of urinary bladder motility by a spinal action of U-50488H in rats.

Journal: The Journal of pharmacy and pharmacology 20021201

Title: Structures and pathways of the central nervous system are potentially involved in the serotonergic modulation of gastrointestinal activity.

Journal: Methods and findings in experimental and clinical pharmacology 20021201

Title: Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake.

Journal: Brain research 20021122

Title: Role of 5-HT2A/C receptors in serotonergic modulation of respiratory motor output during tadpole development.

Journal: Respiratory physiology & neurobiology 20021119

Title: The primary structures and myotropic activities of two tachykinins isolated from the African clawed frog, Xenopus laevis.

Journal: Regulatory peptides 20021015

Title: Effect of serotonin (5-HT) on trigeminal rhythmic activities generated in in vitro brainstem block preparations.

Journal: Journal of dental research 20020901

Title: Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse.

Journal: Planta medica 20020901

Title: Suppressive effect of vagal afferents on cervical dorsal horn neurons responding to tooth pulp electrical stimulation in the rat.

Journal: Experimental brain research 20020801

Title: Modulation of serotonergic projection from dorsal raphe nucleus to basolateral amygdala on sleep-waking cycle of rats.

Journal: Brain research 20020726

Title: Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020715

Title: Comparison of effects of khat extract and amphetamine on motor behaviors in mice.

Journal: Journal of ethnopharmacology 20020601

Title: Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat.

Journal: Experimental neurology 20020601

Title: Airway hyperresponsiveness to adenosine induced by lipopolysaccharide in Brown Norway rats.

Journal: British journal of pharmacology 20020501

Title: Role of S2 receptors in the stimulatory effect of serotonin on hemopoietic bone marrow stem cells.

Journal: Bulletin of experimental biology and medicine 20020501

Title: Chronic cervical spinal sensory denervation reveals ineffective spinal pathways to phrenic motoneurons in the rat.

Journal: Neuroscience letters 20020419

Title: Serotonergic mechanisms of the lateral parabrachial nucleus and cholinergic-induced sodium appetite.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020301

Title: Calcium influx into dendrites of the leech Retzius neuron evoked by 5-hydroxytryptamine.

Journal: Cell calcium 20020301

Title: Methiothepin attenuates gastric secretion and motility effects of vagal stimulants at the dorsal vagal complex.

Journal: European journal of pharmacology 20020201

Title: Effects of ketanserin and DOI on spontaneous and 5-HT-evoked peristalsis of the pig ureter in vivo.

Journal: British journal of pharmacology 20020201

Title: Selective serotonin receptor antagonism and leukocyte-independent plasma extravasation during endotoxemia.

Journal: Microvascular research 20020101

Title: The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats.

Journal: British journal of pharmacology 20020101

Title: [Migraine: a disease, not a symptom].

Journal: La Revue du praticien 20020101

Title: [The problems of migraine headache treatment].

Journal: Medicina (Kaunas, Lithuania) 20020101

Title: The role of angiotensin II in regulating catecholamine secretion during hypoxia in rainbow trout Oncorhynchus mykiss.

Journal: The Journal of experimental biology 20011201

Title: Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle.

Journal: British journal of pharmacology 20011101

Title: Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore.

Journal: Life sciences 20011026

Title: [Migraine and facial pain].

Journal: La Revue du praticien 20011015

Title: 5-HT acting on 5-HT(1/2) receptors does not participate in the in vitro hypoxic respiratory depression.

Journal: Neuroscience research 20010901

Title: Methysergide attenuates leukocyte-independent plasma extravasation during endotoxemia.

Journal: Journal of critical care 20010901

Title: Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-L-arginine in rats.

Journal: European journal of pharmacology 20010817

Title: Functional implications of neurotransmitter expression during axonal regeneration: serotonin, but not peptides, auto-regulate axon growth of an identified central neuron.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010801

Title: Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat.

Journal: Brain research 20010608

Title: Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010501

Title: Conditioned antinociception and freezing using electrical stimulation of the dorsal periaqueductal gray or inferior colliculus as unconditioned stimulus are differentially regulated by 5-HT2A receptors in rats.

Journal: Psychopharmacology 20010501

Title: Microinjection of arginine vasopressin into the central nucleus of amygdala suppressed nociceptive jaw opening reflex in freely moving rats.

Journal: Brain research bulletin 20010501

Title: Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats.

Journal: British journal of pharmacology 20010401

Title: Management of hot flashes in breast-cancer survivors.

Journal: The Lancet. Oncology 20010401

Title: Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: opioid, adrenergic and serotonergic interactions.

Journal: Journal of neuroendocrinology 20010301

Title: Endogenous serotonin contributes to a developmental decrease in long-term potentiation in the rat visual cortex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010301

Title: [Treatment of cluster headache].

Journal: La Revue de medecine interne 20010201

Title: Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms.

Journal: Brain research 20010112

Title: Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats.

Journal: British journal of pharmacology 20010101

Title: Role of PAG in the antinociception evoked from the medial or central amygdala in rats.

Journal: Brain research bulletin 20010101

Title: Serotonergic regulation of crustacean hyperglycemic hormone secretion in the crayfish, Procambarus clarkii.

Journal: Physiological and biochemical zoology : PBZ 20010101

Title: Response properties of neurons in the rostroventromedial medulla of neuropathic rats: attempted modulation of responses by [1DMe]NPYF, a neuropeptide FF analogue.

Journal: Neuroscience 20010101

Title: [Effect of methysergide on behavior of rats with various levels of corticosteroids].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20010101

Title: Silent myocardial ischaemia following methysergide overdose.

Journal: Australian and New Zealand journal of medicine 20001201

Title: The association of the combination of sumatriptan and methysergide in myocardial infarction in a premenopausal woman.

Journal: Archives of internal medicine 19990308

Title: Neurotransmitter-mediated open-field behavioral action of CGRP.

Journal: Life sciences 19990101

Title: Coronary side-effect potential of current and prospective antimigraine drugs.

Journal: Circulation 19980707

Title: Activating mutations of the serotonin 5-HT2C receptor.

Journal: Journal of neurochemistry 19970901

Title: Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970601

Title: Involvement of 5-hydroxytryptamine and bradykinin in the hyperalgesia induced in rats by collagenase from Clostridium histolyticum.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970501

Title: Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19961101

Title: [Daily chronic headache in patients with migraine induced by abuse of ergotamine-analgesics: response due to a protocol of outpatient treatment].

Journal: Neurologia (Barcelona, Spain) 19930101

Title: Comparison of kinin-forming and amidolytic activities of four trimucases, oedema-producing and kinin-releasing enzymes, from Trimeresurus mucrosquamatus venom.

Journal: The Journal of pharmacy and pharmacology 19920401

Title: Saint Anthony's fire revisited. Vascular problems associated with migraine medication.

Journal: The Medical journal of Australia 19910121

Title: Chronic pain after methysergide: a new cause of ischemic monomelic neuropathy.

Journal: Regional anesthesia 19910101

Title: [Isolated stenosis of the popliteal artery after treatment with methysergide. An anatomopathologic study].

Journal: Journal des maladies vasculaires 19900101

Title: The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms.

Journal: Neuroscience research 19891101

Title: Antagonists of adenosine and alpha-2-adrenoceptors reverse the anticonvulsant effects of tizanidine in DBA/2 mice.

Journal: Neuropharmacology 19890301

Title: Methysergide-induced psychosis: case report with long-term follow-up.

Journal: Neuropsychobiology 19890101

Title: Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs.

Journal: The Journal of pharmacy and pharmacology 19881201

Title: Successful treatment of levodopa-induced myoclonus and levodopa withdrawal-induced neuroleptic malignant syndrome. A case report.

Journal: Clinical neuropharmacology 19880601

Title: Is monoamine oxidase inhibitor induced myoclonus serotoninergically mediated?

Journal: Journal of neural transmission 19880101

Title: St. Anthony's fire, then and now: a case report and historical review.

Journal: Canadian journal of surgery. Journal canadien de chirurgie 19870701

Title: Methysergide-induced lower extremity arterial insufficiency.

Journal: Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes 19860901

Title: Effects of serotonergic and anticholinergic drugs in haloperidol-induced dystonia in Cebus monkeys.

Journal: Clinical neuropharmacology 19860101

Title: Simulation of acute myopericarditis by constrictive pericardial disease with endomyocardial fibrosis due to methysergide therapy.

Journal: Journal of the American College of Cardiology 19840701

Title: [Sclerodermiform syndrome caused by methysergide].

Journal: Medicina clinica 19840407

Title: Pharmacological, hemodynamic and autonomic nervous system mechanisms responsible for the blood pressure and heart rate lowering effects of pergolide in rats.

Journal: The Journal of pharmacology and experimental therapeutics 19840301

Title: Neuropharmacology of the parasitic trematode, Schistosoma mansoni.

Journal: The American journal of tropical medicine and hygiene 19830101

Title: Arterial complications of migraine treatment with methysergide and parenteral ergotamine.

Journal: British medical journal (Clinical research ed.) 19820724

Title: [Distal mesenteric arteritis: a rare complication of D. methylsergide treatment (author's transl)].

Journal: Journal de radiologie 19810401

Title: [Reversible distal mesenteric arteritis after continuous prolonged treatment with methylsergide].

Journal: La Nouvelle presse medicale 19810321

Title: Methysergide induced mitral valvular insufficiency.

Journal: Connecticut medicine 19800101

Title: Lower extremity arterial insufficiency after long-term methysergide maleate therapy. Its evaluation with Doppler ultrasonic velocity detector.

Journal: Archives of surgery (Chicago, Ill. : 1960) 19790801

Title: Indications for surgical replacement of the mitral valve. With particular reference to common and uncommon causes of mitral regurgitation.

Journal: The American journal of cardiology 19790701

Title: Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on morphine-induced catalepsy in the rat.

Journal: The Journal of pharmacy and pharmacology 19790401

Title: Effect of drugs influencing central serotonergic mechanisms on haloperidol-induced catalepsy.

Journal: Psychopharmacology 19790329

Title: [Methysergide-induced fibrosis. Directives for preventive treatment of migraine with methysergide].

Journal: Ugeskrift for laeger 19790129

Title: p,p'-DDT-induced neurotoxic syndrome: experimental myoclonus.

Journal: Neurology 19781001

Title: Migraine and systemic scleroderma.

Journal: Archives of dermatology 19780401

Title: Methysergide therapy and constrictive pericarditis.

Journal: Annals of internal medicine 19780201

Title: Methysergide-induced heart disease: a case of multivalvular and myocardial fibrosis.

Journal: Circulation 19771101

Title: Methysergide therapy causing vascular insufficiency of the upper limb.

Journal: Canadian journal of surgery. Journal canadien de chirurgie 19770301

Title: Tricyclic-induced myoclonus.

Journal: The American journal of psychiatry 19770101

Title: Acute arterial spasm of the lower extremities after methysergide therapy.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19761120

Title: Constrictive pericarditis due to methysergide therapy.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19760925

Title: [Letter: Pleuropulmonary fibrosis due to methysergide with circulating immune complexes[].

Journal: La Nouvelle presse medicale 19751115

Title: Levodopa-induced myoclonus.

Journal: Archives of neurology 19750501

Title: Methysergide in the treatment of narcolepsy.

Journal: Archives of neurology 19750401

Title: L-dopa hypotension in dogs: evidence for mediation through 5-HT release.

Journal: Archives internationales de pharmacodynamie et de therapie 19741101

Title: Cardiac murmurs and endocardial fibrosis associated with methysergide therapy.

Journal: American heart journal 19741101

Title: Development of heart valve lesions during methysergide therapy.

Journal: British medical journal 19740518

Title: [Treatment of hyperemesis with the antiserotonin substance, UML-491 (deseril)].

Journal: Zentralblatt fur Gynakologie 19730608

Title: [Spasms of the main muscular arteries in the extremities following ingestion of ergotamine-containing drugs].

Journal: Deutsche medizinische Wochenschrift (1946) 19730420

Title: Psychiatric adverse reactions to methysergide.

Journal: The Journal of nervous and mental disease 19720401

Title: [Methysergide-induced retroperitoneal fibrosis].

Journal: Urologia internationalis 19720101

Title: Complications of methysergide therapy: retroperitoneal fibrosis, mitral regurgitation, edema, and hemolytic anemia.

Journal: JAMA 19700713

Title: Comparative trial of serotonin antagonists in the management of migraine.

Journal: British medical journal 19700509

Title: Mitral regurgitation occurring during methsergide (Sansert) therapy.

Journal: Canadian Medical Association journal 19691101

Title: Methysergide in mania.

Journal: Lancet (London, England) 19690222

Title: Silent retroperitoneal fibrosis associated with methysergide therapy.

Journal: JAMA 19681028

Title: Vascular adventitial fibrosis in a patient taking methysergide maleate.

Journal: JAMA 19680318

Title: Retroperitoneal fibrosis secondary to methysergide bimaleate.

Journal: Canadian Medical Association journal 19670527

Title: Abdominal angina as a complication of methysergide maleate therapy.

Journal: JAMA 19670109

Title: Cardiac and pulmonary fibrosis during methysergide therapy for headache.

Journal: Transactions of the American Clinical and Climatological Association 19670101

Title: Aortic obstruction associated with methysergide maleate therapy for headaches.

Journal: JAMA 19661121

Title: Reversible mesenteric artery stenoses due to methysergide maleate.

Journal: JAMA 19661031

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Tags:129-49-7 Molecular Formula|129-49-7 MDL|129-49-7 SMILES|129-49-7 Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8b)-,(2Z)-2-butenedioate (1:1) (salt)