Home Quinolines 129075-73-6
129075-73-6,MFCD02258932
Catalog No.:AA000YRM

129075-73-6 | 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-

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1mg
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5mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000YRM
Chemical Name:
1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
CAS Number:
129075-73-6
Molecular Formula:
C18H26N2O2
Molecular Weight:
302.4112
MDL Number:
MFCD02258932
SMILES:
O=C1NCCc2c1cccc2OCCCCN1CCCCC1
Properties
Computed Properties
 
Complexity:
355  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
2.8  

Literature

Title: Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat.

Journal: Journal of neurophysiology 20111201

Title: Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins.

Journal: Neurotoxicity research 20110501

Title: 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

Journal: Journal of medicinal chemistry 20110414

Title: The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.

Journal: The Journal of biological chemistry 20100716

Title: Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells.

Journal: Journal of biochemistry 20100501

Title: Inhibition of poly adenosine diphosphate-ribose polymerase decreases hepatocellular carcinoma growth by modulation of tumor-related gene expression.

Journal: Hepatology (Baltimore, Md.) 20100101

Title: Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.

Journal: Bioorganic & medicinal chemistry 20091101

Title: Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.

Journal: Journal of neurochemistry 20091001

Title: MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea.

Journal: British journal of cancer 20090804

Title: Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos).

Journal: Journal of neurochemistry 20090701

Title: Involvement of independent mechanism upon poly(ADP-ribose) polymerase (PARP) activation in methylmercury cytotoxicity in rat cerebellar granule cell culture.

Journal: Journal of neuroscience research 20081115

Title: Prolonged exposures of cerebellar granule neurons to S-nitroso-N-acetylpenicillamine (SNAP) induce neuronal damage independently of peroxynitrite.

Journal: Brain research 20080916

Title: Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation.

Journal: Journal of cellular and molecular medicine 20080801

Title: Adenosine receptor ligands protect against a combination of apoptotic and necrotic cell death in cerebellar granule neurons.

Journal: Experimental brain research 20080301

Title: Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes.

Journal: Journal of neuroscience research 20071115

Title: N-methyl-N'-nitro-N-nitrosoguanidine activates multiple cell death mechanisms in human fibroblasts.

Journal: DNA and cell biology 20070901

Title: Combination treatment with arsenic trioxide and phytosphingosine enhances apoptotic cell death in arsenic trioxide-resistant cancer cells.

Journal: Molecular cancer therapeutics 20070101

Title: Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis.

Journal: Cancer research 20060601

Title: Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression.

Journal: BMC molecular biology 20060101

Title: Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release.

Journal: Blood 20050215

Title: Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050215

Title: NAD+ as a metabolic link between DNA damage and cell death.

Journal: Journal of neuroscience research 20050101

Title: Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures.

Journal: Neuropharmacology 20050101

Title: Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria.

Journal: Cancer research 20041215

Title: Adenine nucleotide metabolism and cell fate after oxidant exposure of rat cortical neurons: effects of inhibition of poly(ADP-ribose) polymerase.

Journal: Brain research 20040702

Title: An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors.

Journal: Analytical biochemistry 20040301

Title: Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex.

Journal: Neuroscience letters 20040206

Title: Differential role of poly(ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro.

Journal: Molecular and cellular neurosciences 20040101

Title: Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031119

Title: Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020601

Title: Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia.

Journal: Cell death and differentiation 20010901

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Tags:129075-73-6 Molecular Formula|129075-73-6 MDL|129075-73-6 SMILES|129075-73-6 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-