Home Other Building Blocks 129938-20-1
129938-20-1,MFCD08272809
Catalog No.:AA00HRWN

129938-20-1 | Dapoxetine, HCl

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
97%
in stock  
$12.00   $8.00
- +
1g
97%
in stock  
$32.00   $23.00
- +
5g
97%
in stock  
$79.00   $55.00
- +
25g
≥ 98.5%
in stock  
$208.00   $145.00
- +
100g
≥ 98.5%
in stock  
$500.00   $350.00
- +
250g
≥ 98.5%
in stock  
$1,165.00   $815.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HRWN
Chemical Name:
Dapoxetine, HCl
CAS Number:
129938-20-1
Molecular Formula:
C21H24ClNO
Molecular Weight:
341.8744
MDL Number:
MFCD08272809
SMILES:
CN([C@H](c1ccccc1)CCOc1cccc2c1cccc2)C.Cl
Properties
Computed Properties
 
Complexity:
337  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:SUZHOUUUGENEBIOPHARMA-CN103664659,2016,BLocationinpatent:Paragraph0049;0050

[2]CurrentPatentAssignee:YANGTZERIVERPHARMACEUTICALGROUPCOLTD-CN113801027,2021,ALocationinpatent:Paragraph0004;0013-0014

[3]CurrentPatentAssignee:SHANGHAIFOSUNPHARMACEUTICAL(GROUP)CO.,LTD.-CN103373931,2016,BLocationinpatent:Paragraph0100-0103

[4]CurrentPatentAssignee:SYMEDLABSLIMITED-WO2011/161690,2011,A1Locationinpatent:Page/Pagecolumn29

[5]CurrentPatentAssignee:SHANDONGACADOFMEDICALSCIENCES-CN105732309,2016,ALocationinpatent:Paragraph0037;0055

[6]CurrentPatentAssignee:LIAOCHENGUNIVERSITY-CN106748825,2017,ALocationinpatent:Paragraph0045

[7]CurrentPatentAssignee:HYGEIACHENGDUPHARMACEUTICALTECHNIQUE-CN107473977,2017,ALocationinpatent:Paragraph0034;0037;0038;0039;0040;0041;0042;0043

[8]CurrentPatentAssignee:HUNANJIUDIANPHARMACEUTICAL;HUNANJIUDIANHONGYANGPHARMACY-CN113880721,2022,ALocationinpatent:Paragraph0040;0047-0049;0051;0057-0058;0061-0063

[9]CurrentPatentAssignee:GUANGZHOUBAIYUNSHANPHARMACEUTICALHOLDINGSCO.,LTD.-CN107935868,2018,ALocationinpatent:Paragraph0045-0054

[10]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-WO2008/35358,2008,A2Locationinpatent:Page/Pagecolumn8;13

[11]CurrentPatentAssignee:RLFINECHEM-WO2014/24205,2014,A1Locationinpatent:Page/Pagecolumn11

[12]CurrentPatentAssignee:HUNANUNIVERSITYOFCHINESEMEDICINE-CN104610076,2016,BLocationinpatent:Paragraph0088-0091

[13]CurrentPatentAssignee:ANHUIJINNANMEDICALTECH-CN106748817,2017,ALocationinpatent:Paragraph0052;0053

[14]CurrentPatentAssignee:TSINGHUATONGFANGCO.,LTD-CN109503397,2019,ALocationinpatent:Paragraph0039;0049

321-38-0    82769-75-3   
Dapoxetinehydrochloride 

[1]Patent:CN106883133,2017,A.Locationinpatent:Paragraph0048-0049;0095;0098-0100

[2]Patent:WO2011/161690,2011,A1

[3]Patent:CN105061230,2017,B.Locationinpatent:Paragraph0085;0086;0088

[1]CurrentPatentAssignee:SYMEDLABSLIMITED-WO2011/161690,2011,A1

[2]CurrentPatentAssignee:SYMEDLABSLIMITED-WO2011/161690,2011,A1

[3]CurrentPatentAssignee:SHANGHAIFOSUNPHARMACEUTICAL(GROUP)CO.,LTD.-CN103373931,2016,B

[4]CurrentPatentAssignee:HUNANUNIVERSITYOFCHINESEMEDICINE-CN104610076,2016,B

[5]CurrentPatentAssignee:LIAOCHENGUNIVERSITY-CN106748825,2017,A

1621684-78-3   
CASUnavailable 
  129938-20-1 

[1]Mahale,RajendraD.;Chaskar,SudhirP.;Patil,KiranE.;Maikap,GolakC.;Gurjar,MukundK.[OrganicProcessResearchandDevelopment,2012,vol.16,#4,p.710-713]

[1]Mahale,RajendraD.;Chaskar,SudhirP.;Patil,KiranE.;Maikap,GolakC.;Gurjar,MukundK.[OrganicProcessResearchandDevelopment,2012,vol.16,#4,p.710-713]

[2]CurrentPatentAssignee:RLFINECHEM-WO2014/24205,2014,A1

[3]CurrentPatentAssignee:RLFINECHEM-WO2014/24205,2014,A1

[4]CurrentPatentAssignee:ANHUIJINNANMEDICALTECH-CN106748817,2017,A

Literature

Title: Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins.

Journal: Toxicology and applied pharmacology 20161115

Title: Effect of dapoxetine on ejaculatory performance and related brain neuronal activity in rapid ejaculator rats.

Journal: The journal of sexual medicine 20121001

Title: A prospective randomized study to compare pelvic floor rehabilitation and dapoxetine for treatment of lifelong premature ejaculation.

Journal: International journal of andrology 20120801

Title: Effects of dapoxetine on cloned Kv1.5 channels expressed in CHO cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120701

Title: Block of cloned Kv4.3 potassium channels by dapoxetine.

Journal: Neuropharmacology 20120601

Title: A benefit-risk assessment of dapoxetine in the treatment of premature ejaculation.

Journal: Drug safety 20120501

Title: Chiral recognition of dapoxetine enantiomers with methylated-gamma-cyclodextrin: a validated capillary electrophoresis method.

Journal: Journal of pharmaceutical and biomedical analysis 20120325

Title: Patient reporting encouraged during monitoring of dapoxetine in New Zealand.

Journal: Drug safety 20111101

Title: Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation.

Journal: The journal of sexual medicine 20111001

Title: An overview of pharmacotherapy in premature ejaculation.

Journal: The journal of sexual medicine 20111001

Title: Cardiovascular safety profile of dapoxetine during the premarketing evaluation.

Journal: Drugs in R&D 20110301

Title: Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials.

Journal: The journal of sexual medicine 20110201

Title: Dapoxetine for premature ejaculation.

Journal: Clinical pharmacology and therapeutics 20110101

Title: Update on treatments for premature ejaculation.

Journal: International journal of clinical practice 20110101

Title: Pharmacokinetics of dapoxetine hydrochloride in healthy Chinese, Japanese, and Caucasian men.

Journal: Journal of clinical pharmacology 20101201

Title: [Dapoxetine in treatment of premature ejaculation: a systematic review].

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20100818

Title: Counterfeit dapoxetine sold on the Internet contains undisclosed sildenafil.

Journal: International journal of clinical practice 20100801

Title: Dapoxetine: in premature ejaculation.

Journal: Drugs 20100730

Title: Dapoxetine for premature ejaculation.

Journal: Expert opinion on pharmacotherapy 20100701

Title: Available and future therapies for premature ejaculation.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100701

Title: Validity of the patient-reported Clinical Global Impression of Change as a measure of treatment response in men with premature ejaculation.

Journal: The journal of sexual medicine 20100601

Title: Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials.

Journal: The journal of sexual medicine 20100601

Title: The dapoxetine paradox.

Journal: BJU international 20100401

Title: Premature ejaculation: treatment update.

Journal: International journal of STD & AIDS 20100201

Title: Dapoxetine. Premature ejaculation: not worth the risk.

Journal: Prescrire international 20100201

Title: Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine.

Journal: The journal of sexual medicine 20100101

Title: Highly efficient, enantioselective syntheses of (S)-(+)- and (R)-(-)-dapoxetine starting with 3-phenyl-1-propanol.

Journal: The Journal of organic chemistry 20100101

Title: Isolation and structural elucidation of dapoxetine as an adulterant in a health supplement used for sexual performance enhancement.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Dapoxetine: a novel treatment for premature ejaculation.

Journal: Drugs of today (Barcelona, Spain : 1998) 20090901

Title: Central regulation of ejaculation and the therapeutic role of serotonergic agents in premature ejaculation.

Journal: Current opinion in investigational drugs (London, England : 2000) 20090701

Title: Pharmacokinetic, pharmacodynamic, and electrocardiographic effects of dapoxetine and moxifloxacin compared with placebo in healthy adult male subjects.

Journal: Journal of clinical pharmacology 20090601

Title: [Premature ejaculation].

Journal: Der Urologe. Ausg. A 20090601

Title: Dapoxetine debate and conflict of interest.

Journal: The journal of sexual medicine 20090501

Title: Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries.

Journal: European urology 20090401

Title: Editorial comment on: Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries.

Journal: European urology 20090401

Title: Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial.

Journal: BJU international 20090301

Title: The Premature Ejaculation Profile: validation of self-reported outcome measures for research and practice.

Journal: BJU international 20090201

Title: MMIX: annus festine lente?

Journal: BJU international 20090101

Title: Effect of dapoxetine on the pharmacokinetics and hemodynamic effects of tamsulosin in men on a stable dose of tamsulosin.

Journal: Journal of clinical pharmacology 20081201

Title: Rational use of dapoxetine for the treatment of premature ejaculation.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081001

Title: Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: results from phase III trials with dapoxetine.

Journal: BJU international 20080901

Title: Re: François Giuliano, Donald L. Patrick, Hartmut Porst, et Al. for the 3004 study group. Premature ejaculation: results from a five-country European observational study. Eur urol 2008;53:1048-57.

Journal: European urology 20080601

Title: Safety and efficacy of dapoxetine in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080501

Title: Regarding Waldinger and Schweitzer's 'premature ejaculation and pharmaceutical company-based medicine: the dapoxetine case'.

Journal: The journal of sexual medicine 20080401

Title: Premature ejaculation and pharmaceutical company-based medicine: the dapoxetine case.

Journal: The journal of sexual medicine 20080401

Title: Interview with Dr François Giuliano (by Christine McKillop). New avenues in the pharmacological treatment of premature ejaculation.

Journal: European urology 20071001

Title: W is for Wilbert's wee willy (which tends to go off prematurely).

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070925

Title: The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men.

Journal: The journal of sexual medicine 20070701

Title: Identifying and treating premature ejaculation: importance of the sexual history.

Journal: Cleveland Clinic journal of medicine 20070501

Title: [Update of pharmacotherapy for premature ejaculation].

Journal: Zhonghua nan ke xue = National journal of andrology 20070501

Title: Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine.

Journal: European urology 20070301

Title: Dapoxetine has no pharmacokinetic or cognitive interactions with ethanol in healthy male volunteers.

Journal: Journal of clinical pharmacology 20070301

Title: Effect of acute dapoxetine administration on the pudendal motoneuron reflex in anesthetized rats: comparison with paroxetine.

Journal: The Journal of urology 20070101

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Journal: Clinical neuropharmacology 20070101

Title: Dapoxetine and paroxetine for the treatment of premature ejaculation.

Journal: Clinical neuropharmacology 20070101

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Journal: Lancet (London, England) 20061125

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Journal: Lancet (London, England) 20061111

Title: Medical therapy for premature ejaculation.

Journal: Lancet (London, England) 20060909

Title: Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials.

Journal: Lancet (London, England) 20060909

Title: Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal.

Journal: Journal of clinical pharmacology 20060901

Title: Pharmacologic treatment of rapid ejaculation: levels of evidence-based review.

Journal: Current clinical pharmacology 20060901

Title: Just hold on a minute (or should it be two?).

Journal: BJU international 20060701

Title: What's the point?

Journal: BJU international 20060301

Title: Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation.

Journal: Journal of clinical pharmacology 20060301

Title: Emerging drugs for premature ejaculation.

Journal: Expert opinion on emerging drugs 20060301

Title: Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for 'on-demand' treatment of premature ejaculation.

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Title: Late-stage clinical development in lower urogenital targets: sexual dysfunction.

Journal: British journal of pharmacology 20060201

Title: Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.

Journal: International journal of impotence research 20060101

Title: Comparison of dapoxetine versus paroxetine in patients with premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study.

Journal: Clinical neuropharmacology 20060101

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Title: Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment.

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Title: Dapoxetine: LY 210448.

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Title: The brain leads the way.

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Title: Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89.

Title: Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.

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SDS
Tags:129938-20-1 Molecular Formula|129938-20-1 MDL|129938-20-1 SMILES|129938-20-1 Dapoxetine, HCl