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130-61-0,MFCD00012655
Catalog No.:AA0073R7

130-61-0 | 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride

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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0073R7
Chemical Name:
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride
CAS Number:
130-61-0
Molecular Formula:
C21H27ClN2S2
Molecular Weight:
407.0355
MDL Number:
MFCD00012655
SMILES:
CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1.Cl
Properties
Computed Properties
 
Complexity:
432  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery.

Journal: Journal of medicinal chemistry 20170824

Title: A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.

Journal: Eukaryotic cell 20130201

Title: Anti-angiogenic effects of thioridazine involving the FAK-mTOR pathway.

Journal: Microvascular research 20121101

Title: Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells.

Journal: Apoptosis : an international journal on programmed cell death 20120901

Title: Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells.

Journal: Cell 20120608

Title: Combined therapy with thioridazine decreases plasma levels of quetiapine inTaiwanese schizophrenic patients.

Journal: Therapeutic drug monitoring 20120601

Title: Impact of probe compound in MRP2 vesicular transport assays.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

Title: Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections.

Journal: International journal of antimicrobial agents 20120501

Title: Successful alternative treatment of extensively drug-resistant tuberculosis in Argentina with a combination of linezolid, moxifloxacin and thioridazine.

Journal: The Journal of antimicrobial chemotherapy 20120201

Title: Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent.

Journal: International journal of antimicrobial agents 20120101

Title: Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine.

Journal: In vivo (Athens, Greece) 20120101

Title: Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.

Journal: PloS one 20120101

Title: Thioridazine: an old neuroleptic effective against totally drug resistant tuberculosis.

Journal: Acta medica portuguesa 20120101

Title: Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein.

Journal: Anticancer research 20111201

Title: Thioridazine affects transcription of genes involved in cell wall biosynthesis in methicillin-resistant Staphylococcus aureus.

Journal: FEMS microbiology letters 20110501

Title: Direct modification of bioactive phenothiazines by exposure to laser radiation.

Journal: Recent patents on anti-infective drug discovery 20110501

Title: The broad-spectrum antimycobacterial activities of phenothiazines, InVitro: somewhere in all of this there may be patentable potentials.

Journal: Recent patents on anti-infective drug discovery 20110501

Title: New patentable use of an old neuroleptic compound thioridazine to combat tuberculosis: a gene regulation perspective.

Journal: Recent patents on anti-infective drug discovery 20110501

Title: Effective therapy with the neuroleptic thioridazine as an adjunct to second line of defence drugs, and the potential that thioridazine offers for new patents that cover a variety of 'new uses'.

Journal: Recent patents on anti-infective drug discovery 20110501

Title: Thioridazine: the good and the bad.

Journal: Recent patents on anti-infective drug discovery 20110501

Title: Latent tuberculosis: is there a role for thioridazine?

Journal: Recent patents on anti-infective drug discovery 20110501

Title: Direct visualization of phase separation induced by phenothiazine-type antipsychotic drugs in model lipid membranes.

Journal: Molecular membrane biology 20110201

Title: Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures.

Journal: The Journal of parasitology 20110201

Title: Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase.

Journal: Basic & clinical pharmacology & toxicology 20110101

Title: A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells.

Journal: Gynecologic oncology 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Therapy Of XDR TB with thioridazine a drug beyond patent protection but eligible for patent 'as new use'.

Journal: Recent patents on anti-infective drug discovery 20100601

Title: Colloids as a sink for certain pharmaceuticals in the aquatic environment.

Journal: Environmental science and pollution research international 20100501

Title: Dietary plant components ellagic acid and tannic acid inhibit Escherichia coli biofilm formation.

Journal: Journal of medical microbiology 20100401

Title: Protein binding-dependent decreases in hERG channel blocker potency assessed by whole-cell voltage clamp in serum.

Journal: Journal of cardiovascular pharmacology 20100401

Title: Inhibition of Listeria monocytogenes infection by neurological drugs.

Journal: International journal of antimicrobial agents 20100301

Title: Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74.

Journal: International journal of antimicrobial agents 20100201

Title: A study on the adsorption characteristics of an amphiphilic phenothiazine drug on activated charcoal in the presence of surfactants.

Journal: Colloids and surfaces. B, Biointerfaces 20100101

Title: Interferences of the autonomic nervous system with drug induced QT prolongation: a point to consider in non-clinical safety studies.

Journal: Journal of pharmacological and toxicological methods 20100101

Title: A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine.

Journal: PloS one 20100101

Title: The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis.

Journal: PloS one 20100101

Title: The role of efflux pumps in macrolide resistance in Mycobacterium avium complex.

Journal: International journal of antimicrobial agents 20091201

Title: Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.

Journal: Chemico-biological interactions 20091007

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Optimization of dispersive liquid-liquid microextraction for the selective determination of trace amounts of palladium by flame atomic absorption spectroscopy.

Journal: Journal of hazardous materials 20090930

Title: Determination of enantiomerization barrier of thioridazine by dynamic capillary electrophoresis using sulfated cyclodextrins as chiral selectors.

Journal: Electrophoresis 20090901

Title: Relevance of CYP2D6 -1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients.

Journal: Pharmacogenomics 20090701

Title: Extraction and determination of some psychotropic drugs in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20090220

Title: Calculation of QT shift in non clinical safety pharmacology studies.

Journal: Journal of pharmacological and toxicological methods 20090101

Title: The risks and benefits of switching antipsychotics: a case study approach.

Journal: Perspectives in psychiatric care 20090101

Title: Characterization of intrinsic efflux activity of Enterococcus faecalis ATCC29212 by a semi-automated ethidium bromide method.

Journal: In vivo (Athens, Greece) 20090101

Title: Reversal of methicillin resistance in Staphylococcus aureus by thioridazine.

Journal: The Journal of antimicrobial chemotherapy 20081201

Title: Efflux-mediated response of Staphylococcus aureus exposed to ethidium bromide.

Journal: The Journal of antimicrobial chemotherapy 20080901

Title: Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis.

Journal: The Journal of antimicrobial chemotherapy 20080501

Title: Stereoselective analysis of thioridazine-2-sulfoxide and thioridazine-5-sulfoxide: an investigation of rac-thioridazine biotransformation by some endophytic fungi.

Journal: Journal of pharmaceutical and biomedical analysis 20080414

Title: Metoclopramide, an increasingly recognized cause of tardive dyskinesia.

Journal: Journal of clinical pharmacology 20080301

Title: Knowledge of pharmacists regarding ritalin and ADHD and their attitude towards the use of ritalin to treat ADHD.

Journal: International journal of clinical pharmacology and therapeutics 20080201

Title: The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080101

Title: Inhibitors of Ca2+ and K+ transport enhance intracellular killing of M. tuberculosis by non-killing macrophages.

Journal: In vivo (Athens, Greece) 20080101

Title: [Repercussions of the withdrawal of thioridazine].

Journal: Actas espanolas de psiquiatria 20080101

Title: [Predictors of the efficacy of methods for psychocorrection in patients with irritable bowel syndrome and constipation].

Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20080101

Title: Endophytic fungi as models for the stereoselective biotransformation of thioridazine.

Journal: Applied microbiology and biotechnology 20071201

Title: Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses.

Journal: Clinical pharmacology and therapeutics 20071101

Title: Factors affecting drug concentrations and QT interval during thioridazine therapy.

Journal: Clinical pharmacology and therapeutics 20071101

Title: Thioridazine: resurrection as an antimicrobial agent?

Journal: British journal of clinical pharmacology 20071101

Title: Enantioseparation of phenothiazines in CD-modified CZE using single isomer sulfated CD as a chiral selector.

Journal: Electrophoresis 20071101

Title: [Seeing a new classification of active medications in psychoses].

Journal: L'Encephale 20071001

Title: Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070801

Title: Thioridazine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20070718

Title: Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.

Journal: International journal of antimicrobial agents 20070601

Title: No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients.

Journal: European journal of clinical pharmacology 20070501

Title: An incorrect diagnosis of psychosis?

Journal: Australian family physician 20070401

Title: Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs.

Journal: Journal of pharmacological and toxicological methods 20070101

Title: [Polymorphic ventricular tachycardia of torsade de pointes type in patient with schizophrenia treated with thioridazine].

Journal: Polskie Archiwum Medycyny Wewnetrznej 20061201

Title: Effect of thioridazine on gap junction intercellular communication in connexin 43-expressing cells.

Journal: Cell biology and toxicology 20060701

Title: 'Non-Antibiotics': alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries.

Journal: Current drug targets 20060701

Title: Effects of antipsychotic drugs on I(to), I (Na), I (sus), I (K1), and hERG: QT prolongation, structure activity relationship, and network analysis.

Journal: Pharmaceutical research 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Classification of antipsychotic drugs by gene expression in the frontal cortex of mice.

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20060401

Title: Planned complex suicide: report of three cases.

Journal: Forensic science international 20060310

Title: Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060301

Title: Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface.

Journal: Biophysical chemistry 20060201

Title: Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model.

Journal: Current drug metabolism 20060201

Title: In vitro phototoxicity of phenothiazines: involvement of stable UVA photolysis products formed in aqueous medium.

Journal: Chemical research in toxicology 20060101

Title: Thioridazine induces immediate and delayed erythema in photopatch test.

Journal: Photochemistry and photobiology 20060101

Title: Thioridazine reduces resistance of methicillin-resistant staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump.

Journal: In vivo (Athens, Greece) 20060101

Title: Progressive severe visual loss after long-term withdrawal from thioridazine treatment.

Journal: European journal of ophthalmology 20060101

Title: Antipsychotic medication dispensing and associated odds ratios of death in elderly veterans and war widows, 2001.

Journal: The Australian and New Zealand journal of psychiatry 20060101

Title: Schizophrenia.

Journal: Clinical evidence 20051201

Title: Clinical toxicology: clinical science to public health.

Journal: Clinical and experimental pharmacology & physiology 20051101

Title: Practical application of guinea pig telemetry system for QT evaluation.

Journal: The Journal of toxicological sciences 20050801

Title: Role of liquid membrane phenomenon in the biological actions of thioridazine.

Journal: Colloids and surfaces. B, Biointerfaces 20050610

Title: Atypical antipsychotic drugs and diabetes mellitus in a large outpatient population: a retrospective cohort study.

Journal: Pharmacoepidemiology and drug safety 20050601

Title: The difference between the formal and the functional dose: the case of the patient on thioridazine and fluvoxamine.

Journal: Journal of psychiatric practice 20050501

Title: Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine.

Journal: The international journal of biochemistry & cell biology 20050401

Title: The effect of lovastatin and thioridazine on the degradation of cocaine in human serum in vitro.

Journal: Therapeutic drug monitoring 20050401

Title: [Sonapax use in the clinical practice].

Journal: Voenno-meditsinskii zhurnal 20050401

Title: Thioridazine inhibits risperidone metabolism: a clinically relevant drug interaction.

Journal: Journal of clinical psychopharmacology 20050201

Title: The in vitro activity of phenothiazines against Mycobacterium avium: potential of thioridazine for therapy of the co-infected AIDS patient.

Journal: In vivo (Athens, Greece) 20050101

Title: Direct effects of neuroleptics on the activity of CYP2A in the liver of rats.

Journal: Pharmacological reports : PR 20050101

Title: Interactions between neuroleptics and CYP2C6 in rat liver--in vitro and ex vivo study.

Journal: Pharmacological reports : PR 20050101

Title: Degradation and configurational changes of thioridazine 2-sulfoxide.

Journal: Journal of pharmaceutical and biomedical analysis 20041115

Title: Antipsychotic drug prescribing in the elderly is cause for concern.

Journal: International clinical psychopharmacology 20041101

Title: Repeated dosing with donepezil does not affect the safety, tolerability or pharmacokinetics of single-dose thioridazine in young volunteers.

Journal: British journal of clinical pharmacology 20041101

Title: Diastereotopic analysis of mesoridazine besylate (Serentil).

Journal: Chirality 20041001

Title: CSM thioridazine advice.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20040801

Title: CSM thioridazine advice.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20040801

Title: Oxidative stress plays an important role in the pathogenesis of drug-induced retinopathy.

Journal: Experimental biology and medicine (Maywood, N.J.) 20040701

Title: Electrochemical measurement of phenothiazine-interacted DNA.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20040601

Title: Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice.

Journal: International journal of antimicrobial agents 20040601

Title: [Psychopharmaceuticals and arrhythmias].

Journal: Therapeutische Umschau. Revue therapeutique 20040401

Title: Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine.

Journal: Biochemistry 20040302

Title: A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.

Journal: Journal of clinical psychopharmacology 20040201

Title: Retrospective cohort study of diabetes mellitus and antipsychotic treatment in a geriatric population in the United States.

Journal: Journal of the American Medical Directors Association 20040101

Title: Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors.

Journal: Journal of molecular neuroscience : MN 20040101

Title: Tricyclic antidepressants, QT interval prolongation, and torsade de pointes.

Journal: Psychosomatics 20040101

Title: Antimicrobial activity of phenothiazines.

Journal: In vivo (Athens, Greece) 20040101

Title: Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study.

Journal: In vivo (Athens, Greece) 20040101

Title: Thioridazine retinopathy.

Journal: Clinical & experimental ophthalmology 20031201

Title: Dependence and chronic psychosis with D-nor-pseudoephedrine.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20031201

Title: Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro.

Journal: International journal of antimicrobial agents 20030901

Title: The in-vitro antimicrobial effect of non-antibiotics and putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus.

Journal: International journal of antimicrobial agents 20030901

Title: Enantioseparation of phenothiazines in cyclodextrin-modified capillary zone electrophoresis: reversal of migration order.

Journal: Electrophoresis 20030901

Title: Neuroleptic malignant syndrome: a case that may shed new light into the etiology and treatment.

Journal: The Australian and New Zealand journal of psychiatry 20030801

Title: Study on thioridazine 5-sulfoxide epimerization and degradation by capillary electrophoresis.

Journal: Electrophoresis 20030801

Title: Racemization and degradation of thioridazine and thioridazine 2-sulfone in human plasma and aqueous solutions.

Journal: Chirality 20030601

Title: Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland.

Journal: British journal of clinical pharmacology 20030601

Title: Re: Thioridazine: re-evaluating the risk/benefit equation.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20030601

Title: A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens.

Journal: Psychopharmacology 20030501

Title: Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.

Journal: European journal of clinical pharmacology 20030501

Title: Photosensitization of DNA strand breaks by three phenothiazine derivatives.

Journal: Chemical research in toxicology 20030501

Title: Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis.

Journal: Antimicrobial agents and chemotherapy 20030301

Title: Safety in treating bipolar disorder.

Journal: The Journal of family practice 20030301

Title: Cutaneous drug reaction case reports: from the world literature.

Journal: American journal of clinical dermatology 20030101

Title: Antipsychotic drugs and QT interval prolongation.

Journal: The Psychiatric quarterly 20030101

Title: Interaction of thioridazine with ocular melanin in vitro.

Journal: Acta poloniae pharmaceutica 20030101

Title: Analytical studies and application of reaction of promazine and thioridazine hydrochlorides with some oxidants.

Journal: Acta poloniae pharmaceutica 20030101

Title: Calcium channel blocking activity of thioridazine, clomipramine and fluoxetine in isolated rat vas deferens: a relative potency measurement study.

Journal: The Journal of urology 20021201

Title: ANCA-positive vasculitis induced by thioridazine: confirmed by rechallenge.

Journal: The British journal of dermatology 20021201

Title: The potential cardiotoxicity of antipsychotic drugs as assessed by heart rate variability.

Journal: Journal of psychopharmacology (Oxford, England) 20021201

Title: QTc interval lengthening is related to CYP2D6 hydroxylation capacity and plasma concentration of thioridazine in patients.

Journal: Journal of psychopharmacology (Oxford, England) 20021201

Title: Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data.

Journal: BMJ (Clinical research ed.) 20021109

Title: Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Simultaneous LC determination of some antidepressants combined with neuroleptics.

Journal: Journal of pharmaceutical and biomedical analysis 20020701

Title: Retinopathy as a result of long-term use of thioridazine.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20020701

Title: Pathogenesis of degenerative retinopathies induced by thioridazine and other antipsychotics: a dopamine hypothesis.

Journal: Documenta ophthalmologica. Advances in ophthalmology 20020701

Title: Fever and sweats in the patient with advanced cancer.

Journal: Hematology/oncology clinics of North America 20020601

Title: Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020501

Title: Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms.

Journal: British journal of pharmacology 20020501

Title: The safety and pharmacokinetics of quetiapine when coadministered with haloperidol, risperidone, or thioridazine.

Journal: Journal of clinical psychopharmacology 20020401

Title: Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020301

Title: Effects of antipsychotic drugs on operant responding after acute and repeated administration.

Journal: Psychopharmacology 20020301

Title: Melleril: gone forever!

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20020201

Title: Spectrophotometric determination of the phosphatidylcholine liposomes/water partition coefficients and the protonation equilibrium constants of phenothiazine derivatives.

Journal: Cellular & molecular biology letters 20020101

Title: Adverse drug reaction update.

Journal: Adverse drug reactions and toxicological reviews 20020101

Title: Thioridazine-fluoxetine interaction at the level of the distribution process in vivo.

Journal: Polish journal of pharmacology 20020101

Title: Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.

Journal: Therapeutic drug monitoring 20011201

Title: Bifonazole modulates death of cultured cerebellar granular cells induced by glutamate and oxygen-glucose deprivation.

Journal: Bulletin of experimental biology and medicine 20011101

Title: Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation.

Journal: European journal of pharmacology 20011005

Title: Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping.

Journal: British journal of pharmacology 20011001

Title: Removal of thioridazine from primary care formulary will result in prescribing vacuum.

Journal: BMJ (Clinical research ed.) 20010922

Title: Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy.

Journal: The Journal of antimicrobial chemotherapy 20010501

Title: The effects of sodium bicarbonate on thioridazine-induced cardiac dysfunction in the isolated perfused rat heart.

Journal: Veterinary and human toxicology 20010401

Title: An animal model of extrapyramidal side effects induced by antipsychotic drugs: relationship with D2 dopamine receptor occupancy.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20010401

Title: Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines.

Journal: International journal of antimicrobial agents 20010301

Title: Repeated episodes of hypothermia in a subject treated with haloperidol, levomepromazine, olanzapine, and thioridazine.

Journal: Journal of clinical psychopharmacology 20010201

Title: Thioridazine (Mellaril) and mesoridazine (Serentil): prolongation of the QTc interval.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20010109

Title: Thioridazine for dementia.

Journal: The Cochrane database of systematic reviews 20010101

Title: Ping-pong gaze in combined intoxication with tranylcypromine, thioridazine, and clomipramine.

Journal: Neuropsychiatry, neuropsychology, and behavioral neurology 20010101

Title: Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes.

Journal: British journal of pharmacology 20000401

Title: Ocular toxicity of systemic medications: a case series.

Journal: Optometry (St. Louis, Mo.) 20000101

Title: Thioridazine, diarrhoea and torsades de pointe.

Journal: Journal of the Royal Society of Medicine 19980301

Title: Extrapyramidal side effects in patients with Alzheimer's disease treated with low-dose neuroleptic medication.

Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 19980101

Title: Clozapine withdrawal resulting in delirium with psychosis: a report of three cases.

Journal: The Journal of clinical psychiatry 19970601

Title: Attenuation of antipsychotic-induced hyperprolactinemia with clozapine.

Journal: Journal of child and adolescent psychopharmacology 19970101

Title: Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: potential use for initial therapy of freshly diagnosed tuberculosis.

Journal: The Journal of antimicrobial chemotherapy 19961201

Title: Anticholinergic overdose induced torsade de pointes successfully treated with verapamil.

Journal: Japanese heart journal 19961101

Title: Thioridazine-induced retinopathy.

Journal: The American journal of psychiatry 19960901

Title: Thioridazine cardiotoxicity.

Journal: Journal of toxicology. Clinical toxicology 19960101

Title: Low-dose imipramine for thioridazine-induced male orgasmic disorder.

Journal: Journal of sex & marital therapy 19960101

Title: Catatonic syndrome following recovery from neuroleptic malignant syndrome.

Journal: Journal of intellectual disability research : JIDR 19951001

Title: Thioridazine withdrawal-induced behavioral deterioration treated with clonidine: two case reports.

Journal: Mental retardation 19950801

Title: Hypotensive effects of thioridazine in an elderly patient with traumatic brain injury.

Journal: Brain injury 19940101

Title: [Iatrogenic torsade de pointes induced by thioridazine].

Journal: Minerva cardioangiologica 19920601

Title: Transient cardiac pacing is insufficiently used to treat arrhythmia associated with thioridazine.

Journal: Cardiology 19920101

Title: [Ventricular arrhythmia following thioridazine poisoning].

Journal: Annales de cardiologie et d'angeiologie 19910401

Title: Spectral electroretinography in thioridazine toxicity.

Journal: Annals of ophthalmology 19900801

Title: Ventricular tachycardia associated with desipramine and thioridazine.

Journal: Psychosomatics 19900101

Title: Drug-induced tremor of the tongue.

Journal: Italian journal of neurological sciences 19890201

Title: Attempted strangulation during phenothiazine-induced sleep-walking and night terrors.

Journal: The British journal of psychiatry : the journal of mental science 19881101

Title: Hyperthermia, hypertension, hypertonia, and coma in a massive thioridazine overdose.

Journal: The American journal of emergency medicine 19880701

Title: Meige's syndrome associated with neuroleptic treatment.

Journal: The American journal of psychiatry 19880401

Title: [Mechanism of the development of thioridazine retinopathy].

Journal: Biulleten' eksperimental'noi biologii i meditsiny 19880101

Title: Rapid death resulting from mesoridazine overdose.

Journal: Veterinary and human toxicology 19870201

Title: Iatrogenic torsade de pointes induced by thioridazine.

Journal: Biological psychiatry 19870101

Title: Neuroleptic-induced tics in two hyperactive children.

Journal: The American journal of psychiatry 19860901

Title: Limited effect of magnesium sulphate on torsades de pointes ventricular tachycardia.

Journal: International journal of cardiology 19860801

Title: Neurotoxicity induced by combined lithium-thioridazine treatment.

Journal: Biological psychiatry 19860701

Title: Haloperidol versus thioridazine in the treatment of behavioral symptoms in senile dementia of the Alzheimer's type: preliminary findings.

Journal: The Journal of clinical psychiatry 19860601

Title: Tourette-like syndrome following low dose short-term neuroleptic treatment.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 19860501

Title: Drug-induced dystonia in neuronal ceroid-lipofuscinosis.

Journal: Pediatric neurology 19860101

Title: Susceptibility to drug-induced hypotension in post-partum psychosis.

Journal: International clinical psychopharmacology 19860101

Title: Tics with combined thioridazine-methylphenidate therapy: case report.

Journal: The Journal of clinical psychiatry 19860101

Title: The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report.

Journal: General hospital psychiatry 19851001

Title: Molindone hydrochloride treatment of hospitalized children with conduct disorder.

Journal: The Journal of clinical psychiatry 19850801

Title: Cardiorespiratory depression and haemolysis due to thioridazine overdose in the rat.

Journal: The Journal of pharmacy and pharmacology 19850701

Title: Thioridazine toxicity--an experimental cardiovascular study of thioridazine and its major metabolites in overdose.

Journal: Veterinary and human toxicology 19850401

Title: Effect of bromocriptine mesylate on induced hyperprolactinemia in stabilized psychiatric outpatients undergoing neuroleptic treatment.

Journal: Neuropsychobiology 19850101

Title: Drug-induced parkinsonism in the elderly.

Journal: Lancet (London, England) 19841110

Title: Case report of a possible interaction between neuroleptics and carbamazepine.

Journal: The American journal of psychiatry 19840901

Title: Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain.

Journal: European journal of pharmacology 19840720

Title: Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?

Journal: Journal of clinical psychopharmacology 19840601

Title: Does hyperthyroidism predispose to thioridazine-induced hyperpyrexia and cardiac arrhythmias?

Journal: Postgraduate medical journal 19840601

Title: Hypothermic coma associated with thioradizine in a myxedematous patient.

Journal: The Journal of clinical psychiatry 19840401

Title: Magnesium therapy for torsades de pointes.

Journal: The American journal of cardiology 19840201

Title: Deep-vein thrombosis with antipsychotic drugs.

Journal: Psychosomatics 19831201

Title: Thioridazine-induced torsade de pointes. Successful therapy with isoproterenol.

Journal: JAMA 19830603

Title: Toxic neurological reaction to lithium/thioridazine.

Journal: Lancet (London, England) 19830402

Title: Delirium associated with lithium-induced hypothyroidism: a case report.

Journal: The American journal of psychiatry 19830301

Title: Phenothiazine induced lingual trauma.

Journal: The Laryngoscope 19830101

Title: Efficacy of antipsychotic medications in behaviorally disturbed dementia patients.

Journal: The American journal of psychiatry 19820901

Title: A case of neuroleptic malignant syndrome successfully treated with amantadine.

Journal: The Journal of clinical psychiatry 19820901

Title: Sexual dysfunction in women using major tranquilizers.

Journal: Psychosomatics 19820901

Title: [Recurrent ventricular flutter after thioridazine poisoning].

Journal: Polski tygodnik lekarski (Warsaw, Poland : 1960) 19820621

Title: A danger in making the diagnosis of Parkinson's disease.

Journal: Lancet (London, England) 19820529

Title: Capgras phenomenon, delirium, and transient hepatic dysfunction.

Journal: Hospital & community psychiatry 19820501

Title: Neuroleptic-induced seizures. An in vitro technique for assessing relative risk.

Journal: Archives of general psychiatry 19820201

Title: Pemoline-induced mania.

Journal: Biological psychiatry 19811001

Title: Motility, Parkinsonism, and prolactin with thiothixene and thioridazine.

Journal: Archives of general psychiatry 19810601

Title: The effects of thioridazine on electrical and ischemic ventricular fibrillation in the dog heart in situ.

Journal: The Journal of pharmacology and experimental therapeutics 19810101

Title: Effects of thioridazine on the cognitive functioning of a hypotonic schizophrenic boy.

Journal: The American journal of psychiatry 19801101

Title: Phenothiazine-induced phenytoin intoxication.

Journal: Annals of internal medicine 19800701

Title: Methylphenidate, neuroleptics and dyskinesia-dystonia.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 19800401

Title: Cardiovascular side effects of phenothiazines and tricyclic antidepressants. A review with precautionary measures.

Journal: Postgraduate medicine 19800301

Title: An unusual ocular complication of thioridazine.

Journal: International journal of psychiatry in medicine 19800101

Title: Somnambulistic-like episodes secondary to combined lithium-neuroleptic treatment.

Journal: The British journal of psychiatry : the journal of mental science 19791101

Title: An unusual case of akathisia.

Journal: The American journal of psychiatry 19790801

Title: Neurotoxicity with combined use of lithium and thioridazine.

Journal: The Journal of clinical psychiatry 19790301

Title: Filicide during psychotropic-induced somnambulism: a case report.

Journal: The American journal of psychiatry 19781101

Title: Thioridazine-associated immune hemolytic anemia.

Journal: Southern medical journal 19781101

Title: Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule.

Journal: Canadian Medical Association journal 19781007

Title: Neuropharmacological and behavioral evaluation of prostaglandin E2 and 11-thiol-11-desoxy prostaglandin E2 in the mouse and rat.

Journal: Psychopharmacology 19780531

Title: Cardiac toxicity with thioridazine-tricyclic antidepressant combination.

Journal: The Journal of nervous and mental disease 19770801

Title: Syndrome of inappropriate secretion of antidiuretic hormone in patients treated with psychotherapeutic drugs.

Journal: Archives of neurology 19770601

Title: Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs.

Journal: The American journal of cardiology 19760201

Title: [The extrapyramidal symptoms in the combination of lithium long-term lithium therapy with nortriptyline. A case report on the formation of a pathogenesis hypothesis].

Journal: Der Nervenarzt 19760101

Title: Thioridazine and sexual dysfunction.

Journal: The American journal of psychiatry 19760101

Title: Letter: Acute hypotension from thioridazine.

Journal: JAMA 19751229

Title: Alleviating agitation, apprehension, and related symptoms in geriatric patients: A double-blind comparison of a phenothiazine and a benzodiazepien.

Journal: Southern medical journal 19750601

Title: Drug-induced dystonia.

Journal: The American journal of psychiatry 19750501

Title: Tardive dyskinesia treated with pimozide.

Journal: Journal of the neurological sciences 19750401

Title: Physostigmine. Its use in acute anticholinergic syndrome with antidepressant and antiparkinson drugs.

Journal: Archives of general psychiatry 19750301

Title: Implications of phenothiazine side effects: a study of antiparkinsonian agents in an older population.

Journal: Acta psychiatrica Scandinavica 19750201

Title: Neuroleptic-induced tardiave dyskinesias in nonpsychotic patients.

Journal: Archives of neurology 19740401

Title: Ventricular arrhythmias associated with use of thioridazine hydrochloride in alcohol withdrawal.

Journal: British medical journal 19731124

Title: Thioridazine toxicity. Agranulocytosis and hepatitis with encephalopathy.

Journal: JAMA 19730423

Title: Phenothiazine-induced stress incontinence.

Journal: The Journal of urology 19730401

Title: Aplastic anemia associated with lithium therapy.

Journal: Canadian Medical Association journal 19730317

Title: The therapeutic use of diazepam for akathisia.

Journal: Psychosomatics 19730101

Title: Thioridazine incontinence.

Journal: JAMA 19720110

Title: Recurrent major ventricular arrhythmias associated with thioridazine therapy.

Journal: Minnesota medicine 19711101

Title: Thioridazine in schizophrenia.

Journal: JAMA 19710920

Title: Cardiotoxic effects of Mellaril.

Journal: American heart journal 19700701

Title: Mental disorders caused by isonicotinic acid hydrazide (INH) in the course of treatment of pulmonary tuberculosis.

Journal: Polish medical journal 19700101

Title: Sudden death in phenothiazine therapy. (A clinicopathologic study of 12 cases).

Journal: The Psychiatric quarterly 19700101

Title: [Intraspecific aggressive behavior induced by apomorphine in the rat].

Journal: Psychopharmacologia 19700101

Title: Case report: successful treatment of ventricular tachycardia associated with thioridazine (Mellaril).

Journal: Southern medical journal 19690301

Title: Congenital malformations following phenothiazine administration during pregnancy.

Journal: Canadian Medical Association journal 19690125

Title: Death associated with ventricular arrhythmia and thioridazine hydrochloride.

Journal: JAMA 19680708

Title: [An exceptional therapeutic accident: diabetes insipidus due to thioridazine].

Journal: Journal de medecine de Lyon 19680305

Title: [Hypotensive side effects of thioridazine (Mellaril)].

Journal: Nederlands tijdschrift voor geneeskunde 19670603

Title: Thioridazine-induced cholestasis.

Journal: JAMA 19670403

Title: The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy.

Journal: The Psychiatric quarterly 19670101

Title: Comparison of P-5227 and thioridazine in chronic schizophrenic patients.

Journal: The Journal of clinical pharmacology and the journal of new drugs 19670101

Title: Drug-induced extrapyramidal symptoms: their incidence and treatment.

Journal: The American journal of psychiatry 19670101

Title: Thioridazine (mellaril)-induced ventricular tachycardia controlled with an artificial pacemaker.

Journal: Annals of internal medicine 19661101

Title: Electron microscopic observation of thioridazine-induced hepatitis.

Journal: The Kurume medical journal 19660101

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Tags:130-61-0 Molecular Formula|130-61-0 MDL|130-61-0 SMILES|130-61-0 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride