Home Carboxes 13010-47-4
13010-47-4,MFCD00012392
Catalog No.:AA000TY1

13010-47-4 | Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$7.00   $5.00
- +
5mg
97%(HPLC)
in stock  
$24.00   $17.00
- +
50mg
≥98%
in stock  
$53.00   $37.00
- +
100mg
≥98%
in stock  
$98.00   $68.00
- +
250mg
97%(HPLC)
in stock  
$191.00   $134.00
- +
1g
≥98%
in stock  
$456.00   $319.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000TY1
Chemical Name:
Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-
CAS Number:
13010-47-4
Molecular Formula:
C9H16ClN3O2
Molecular Weight:
233.6952
MDL Number:
MFCD00012392
SMILES:
ClCCN(C(=O)NC1CCCCC1)N=O
Properties
Computed Properties
 
Complexity:
219  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.8  

Literature

Title: Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.

Journal: Toxicology and applied pharmacology 20170301

Title: High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.

Journal: Archives of toxicology 20170101

Title: Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance.

Journal: Cancer research 20141001

Title: The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140701

Title: Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity.

Journal: Toxicology 20140106

Title: Tolerability of lomustine in combination with cyclophosphamide in dogs with lymphoma.

Journal: Journal of the American Animal Hospital Association 20140101

Title: Phase II clinical evaluation of lomustine chemotherapy for feline vaccine-associated sarcoma.

Journal: Veterinary and comparative oncology 20121201

Title: Chemotherapy in low-grade gliomas.

Journal: Current opinion in oncology 20121101

Title: Evaluation of lomustine as a rescue agent for cats with resistant lymphoma.

Journal: Journal of feline medicine and surgery 20121001

Title: Cervicothoracic syringohydromyelia associated with a prosencephalic mass in a dog.

Journal: The Journal of small animal practice 20121001

Title: Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120910

Title: Multifocal cutaneous histiocytic sarcoma in a young dog and review of histiocytic cell immunophenotyping.

Journal: Veterinary clinical pathology 20120901

Title: Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120901

Title: Chemotherapy dose-intensity and survival for childhood medulloblastoma.

Journal: Anticancer research 20120901

Title: Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

Title: Late and prolonged pseudoprogression in glioblastoma after treatment with lomustine and temozolomide.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

Title: Initial treatment patterns over time for anaplastic oligodendroglial tumors.

Journal: Neuro-oncology 20120601

Title: Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma.

Journal: Journal of neuro-oncology 20120501

Title: Dose dense 1 week on/1 week off temozolomide in recurrent glioma: a retrospective study.

Journal: Journal of neuro-oncology 20120501

Title: Autologous noncryopreserved hematopoietic stem cell transplant with CEAM as a modified conditioning regimen in patients with Hodgkin lymphoma: a single-center experience with a new protocol.

Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20120401

Title: The role of chemotherapy in anaplastic astrocytoma patients.

Journal: Journal of Korean Neurosurgical Society 20120401

Title: Role of glutathione-S-transferase (GST) polymorphisms in patients with advanced Hodgkin lymphoma: results from the HD2000 GISL trial.

Journal: Leukemia & lymphoma 20120301

Title: Extraneural metastasis of glioblastoma multiforme presenting as an unusual neck mass.

Journal: Journal of Korean Neurosurgical Society 20120301

Title: Meta-analysis of phase III trials of docetaxel alone or in combination with chemotherapy in metastatic breast cancer.

Journal: Journal of cancer research and clinical oncology 20120201

Title: [Retrospective analysis of 24 recurrent glioblastoma after chemoradiation and treated with nitrosoureas or irinotecan and bevacizumab].

Journal: Bulletin du cancer 20120201

Title: Prophylactic intrathecal chemotherapy in primary CNS lymphoma.

Journal: Journal of neuro-oncology 20120101

Title: Antiangiogenic therapy for patients with recurrent and newly diagnosed malignant gliomas.

Journal: Journal of oncology 20120101

Title: Modulation of pediatric brain tumor autophagy and chemosensitivity.

Journal: Journal of neuro-oncology 20120101

Title: Anaplastic atypical myeloma with extensive cutaneous involvement in a dog.

Journal: The Journal of veterinary medical science 20120101

Title: Prediction of glioblastoma multiform response to bevacizumab treatment using multi-parametric MRI.

Journal: PloS one 20120101

Title: Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures.

Journal: World journal of surgical oncology 20120101

Title: Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses.

Journal: Scientific reports 20120101

Title: A randomized trial investigating the efficacy and safety of water soluble micellar paclitaxel (Paccal Vet) for treatment of nonresectable grade 2 or 3 mast cell tumors in dogs.

Journal: Journal of veterinary internal medicine 20120101

Title: MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR.

Journal: Journal of translational medicine 20120101

Title: Iodine-125 brachytherapy for brain tumours--a review.

Journal: Radiation oncology (London, England) 20120101

Title: Detection of 1p19q deletion by real-time comparative quantitative PCR.

Journal: Biomarker insights 20120101

Title: Co-deletion of chromosome 1p/19q and IDH1/2 mutation in glioma subsets of brain tumors in Chinese patients.

Journal: PloS one 20120101

Title: Inhibition of ERβ induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines.

Journal: PloS one 20120101

Title: Use of a deformable atlas to identify cryptic critical structures in the treatment of glioblastoma multiforme.

Journal: PloS one 20120101

Title: Subgroup economic analysis for glioblastoma in a health resource-limited setting.

Journal: PloS one 20120101

Title: Current trends in targeted therapies for glioblastoma multiforme.

Journal: Neurology research international 20120101

Title: Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings.

Journal: Advances in hematology 20120101

Title: Long-term survival after gamma knife radiosurgery in a case of recurrent glioblastoma multiforme: a case report and review of the literature.

Journal: Case reports in medicine 20120101

Title: Current and emerging pharmacotherapies for primary CNS lymphoma.

Journal: Clinical Medicine Insights. Oncology 20120101

Title: Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells.

Journal: PloS one 20120101

Title: Therapeutic strategies based on polymeric microparticles.

Journal: Journal of biomedicine & biotechnology 20120101

Title: An unusual presentation of tumor lysis syndrome in a patient with advanced gastric adenocarcinoma: case report and literature review.

Journal: Case reports in medicine 20120101

Title: The Risk of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia in Hodgkin Lymphoma has Substantially Decreased in the ABVD Era Abolishing Mechlorethamine and Procarbazine and Limiting Volumes and Doses of Radiotherapy.

Journal: Mediterranean journal of hematology and infectious diseases 20120101

Title: [Combined effect of gemcitabine and lomustine in mice with intracranial transplanted lymphosarcoma LIO-1].

Journal: Voprosy onkologii 20120101

Title: Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas.

Journal: European journal of haematology 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Long-term follow-up analysis of HD9601 trial comparing ABVD versus Stanford V versus MOPP/EBV/CAD in patients with newly diagnosed advanced-stage Hodgkin's lymphoma: a study from the Intergruppo Italiano Linfomi.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111110

Title: Lecture: fotemustine in brain tumors.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20111101

Title: Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.

Journal: Oncotarget 20111101

Title: Outcomes among black patients with stage II and III colon cancer receiving chemotherapy: an analysis of ACCENT adjuvant trials.

Journal: Journal of the National Cancer Institute 20111019

Title: Chemotherapy for diffuse low-grade gliomas in adults.

Journal: Revue neurologique 20111001

Title: Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma.

Journal: Clinics (Sao Paulo, Brazil) 20111001

Title: Immunochemotherapy with rituximab, methotrexate, procarbazine, and lomustine for primary CNS lymphoma (PCNSL) in the elderly.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110901

Title: Sagopilone (ZK-EPO, ZK 219477) for recurrent glioblastoma. A phase II multicenter trial by the European Organisation for Research and Treatment of Cancer (EORTC) Brain Tumor Group.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110901

Title: Leptomeningeal disease in oligodendroglial tumors: a population-based study.

Journal: Journal of neuro-oncology 20110901

Title: Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: a review.

Journal: Journal of neuro-oncology 20110901

Title: NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri.

Journal: Annals of neurology 20110901

Title: Diencephalic tumors in children: a 30-year experience of a single institution.

Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20110801

Title: High-grade gliomas.

Journal: Current treatment options in neurology 20110801

Title: Feasibility and efficacy of repeated chemotherapy for progressive pediatric low-grade gliomas.

Journal: Pediatric blood & cancer 20110715

Title: Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003-2009).

Journal: Journal of the American Veterinary Medical Association 20110715

Title: Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951.

Journal: Cancer 20110701

Title: Glioblastoma: patterns of recurrence and efficacy of salvage treatments.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110701

Title: Implementation of neuro-oncology service reconfiguration in accordance with NICE guidance provides enhanced clinical care for patients with glioblastoma multiforme.

Journal: British journal of cancer 20110607

Title: LACE-conditioned autologous stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma: treatment outcome and risk factor analysis from a single centre.

Journal: Hematological oncology 20110601

Title: Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951.

Journal: Journal of neuro-oncology 20110601

Title: HPLC method validation for the quantification of lomustine to study pharmacokinetics of thermosensitive liposome-encapsulated lomustine containing iohexol for CT imaging in C6 glioma rats.

Journal: European journal of drug metabolism and pharmacokinetics 20110601

Title: International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors.

Journal: Neuro-oncology 20110601

Title: High dose methotrexate for pediatric high grade glioma: results of the HIT-GBM-D pilot study.

Journal: Journal of neuro-oncology 20110501

Title: Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.

Journal: Journal of neuro-oncology 20110501

Title: Treatment of follicular non-Hodgkin's lymphoma with or without rituximab: cost-effectiveness and value of information based on a 5-year follow-up.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20110501

Title: Response of medulloblastoma cells to vincristine and lomustine: role of TRKC, CTNNB1 and STK15.

Journal: Anticancer research 20110501

Title: Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma.

Journal: Journal of neuro-oncology 20110401

Title: CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07).

Journal: Australian veterinary journal 20110401

Title: Identification of diagnostic serum protein profiles of glioblastoma patients.

Journal: Journal of neuro-oncology 20110301

Title: Short topotecan-based induction regimen in newly diagnosed high-risk neuroblastoma.

Journal: European journal of cancer (Oxford, England : 1990) 20110301

Title: Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study.

Journal: Acta neurochirurgica 20110301

Title: A network meta-analysis of randomized controlled trials of induction treatments in acute myeloid leukemia in the elderly.

Journal: Clinical therapeutics 20110301

Title: MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

Journal: Journal of neuro-oncology 20110201

Title: Comparison of oral administration of lomustine and prednisolone or prednisolone alone as treatment for granulomatous meningoencephalomyelitis or necrotizing encephalitis in dogs.

Journal: Journal of the American Veterinary Medical Association 20110201

Title: A stability-indicating liquid chromatographic method for Lomustine.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Polycomb genes expression as a predictor of poor clinical outcome in children with medulloblastoma.

Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20110101

Title: Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: results of a randomized and controlled phase IIb study.

Journal: Neuro-oncology 20110101

Title: Systematic review of medical treatment in melanoma: current status and future prospects.

Journal: The oncologist 20110101

Title: Antiangiogenic agents in the treatment of recurrent or newly diagnosed glioblastoma: analysis of single-agent and combined modality approaches.

Journal: Radiation oncology (London, England) 20110101

Title: A novel SNP analysis method to detect copy number alterations with an unbiased reference signal directly from tumor samples.

Journal: BMC medical genomics 20110101

Title: Tolerability of metronomic administration of lomustine in dogs with cancer.

Journal: Journal of veterinary internal medicine 20110101

Title: O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.

Journal: PloS one 20110101

Title: Lomustine loaded chitosan nanoparticles: characterization and in-vitro cytotoxicity on human lung cancer cell line L132.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: The use of lithium carbonate to prevent lomustine-induced myelosuppression in dogs: a pilot study.

Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20110101

Title: [Cellular markers based on DNA damage and repair (BER, MMR), expression of MLHI, MSH2, FasR, and cell death of lymphocytes as predictive parameters for clinical response to chemotherapy of melanoma].

Journal: Tsitologiia 20110101

Title: Achievement of three year remission with bevacizumab and irinotecan in recurrent glioblastoma multiforme: a case report.

Journal: Clinical Medicine Insights. Oncology 20110101

Title: Long-term survival with primary glioblastoma multiforme: a clinical study in bulgarian patients.

Journal: Case reports in oncology 20110101

Title: High-dose chemotherapy with autologous hematopoietic stem-cell rescue for pediatric brain tumor patients: a single institution experience from UCLA.

Journal: Journal of transplantation 20110101

Title: The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II.

Journal: International journal of molecular imaging 20110101

Title: Bevacizumab for the treatment of recurrent glioblastoma.

Journal: Clinical Medicine Insights. Oncology 20110101

Title: Neutropenia and Neutropenic Complications in ABVD Chemotherapy for Hodgkin Lymphoma.

Journal: Advances in hematology 20110101

Title: The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future.

Journal: Advances in hematology 20110101

Title: Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs.

Journal: Journal of veterinary internal medicine 20110101

Title: Treatment of HIV-related primary central nervous system lymphoma with AZT high dose, HAART, interleukin-2 and foscarnet in three patients.

Journal: European journal of medical research 20110101

Title: Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas.

Journal: PloS one 20110101

Title: Uveal melanoma.

Journal: Journal of skin cancer 20110101

Title: [Effectiveness of DNA repair and expression of MLH1, MSH2 and FASR in lymphocytes of patients with chemotherapy-responsive, disseminated cutaneous melanoma].

Journal: Voprosy onkologii 20110101

Title: [Investigation of gemcitabine plus lomustine treatment in mice with transplantable lymphosarcoma LIO-1].

Journal: Voprosy onkologii 20110101

Title: Nitrosourea chemotherapeutic agents: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea.

Journal: Report on carcinogens : carcinogen profiles 20110101

Title: Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?

Journal: Radiation oncology (London, England) 20110101

Title: Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.

Journal: Molecular cancer 20110101

Title: Long survival of primary diffuse leptomeningeal gliomatosis following radiotherapy and temozolomide: case report and literature review.

Journal: European journal of medical research 20110101

Title: Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.

Journal: BMC cancer 20110101

Title: Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.

Journal: PloS one 20110101

Title: Innovative Therapies against Human Glioblastoma Multiforme.

Journal: ISRN oncology 20110101

Title: Selective internal radiation therapy for gastrointestinal neuroendocrine tumour liver metastases: a new and effective modality for treatment.

Journal: International journal of hepatology 20110101

Title: Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment.

Journal: Clinical & developmental immunology 20110101

Title: [Brain metastasis in breast cancer].

Journal: Voprosy onkologii 20110101

Title: New agents targeting angiogenesis in glioblastoma.

Journal: Chemotherapy research and practice 20110101

Title: Bevacizumab improves quality of life in patients with recurrent glioblastoma.

Journal: Chemotherapy research and practice 20110101

Title: Radiation Dose Escalation in Stage III Non-Small-Cell Lung Cancer.

Journal: Frontiers in oncology 20110101

Title: Combined modality approaches in the management of adult glioblastoma.

Journal: Frontiers in oncology 20110101

Title: Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs.

Journal: Veterinary and comparative oncology 20101201

Title: KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells.

Journal: Brain pathology (Zurich, Switzerland) 20101101

Title: Molecular diagnostics of gliomas: state of the art.

Journal: Acta neuropathologica 20101101

Title: Chemotherapy: Lo and behold, a role for lomustine in acute myeloid leukemia?

Journal: Nature reviews. Clinical oncology 20101101

Title: Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101020

Title: Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update.

Journal: Journal of neuro-oncology 20101001

Title: Prolonged response without prolonged chemotherapy: a lesson from PCV chemotherapy in low-grade gliomas.

Journal: Neuro-oncology 20101001

Title: First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience.

Journal: Neurosurgical review 20101001

Title: Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules.

Journal: British journal of cancer 20100907

Title: Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician's perspective.

Journal: Acta neuropathologica 20100901

Title: Calcitriol (1,25-dihydroxycholecalciferol) enhances mast cell tumour chemotherapy and receptor tyrosine kinase inhibitor activity in vitro and has single-agent activity against spontaneously occurring canine mast cell tumours.

Journal: Veterinary and comparative oncology 20100901

Title: Glioblastoma multiforme in childhood: a case report.

Journal: Clinics (Sao Paulo, Brazil) 20100901

Title: Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib.

Journal: Journal of neuro-oncology 20100801

Title: Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall.

Journal: Acta neuropathologica 20100801

Title: Cognition and quality of life after chemotherapy plus radiotherapy (RT) vs. RT for pure and mixed anaplastic oligodendrogliomas: radiation therapy oncology group trial 9402.

Journal: International journal of radiation oncology, biology, physics 20100701

Title: Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.

Journal: Journal of neuro-oncology 20100701

Title: IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

Journal: Leukemia 20100701

Title: Recurrent high-grade glioma.

Journal: Current treatment options in neurology 20100701

Title: Addition of lomustine to idarubicin and cytarabine improves the outcome of elderly patients with de novo acute myeloid leukemia: a report from the GOELAMS.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100620

Title: Canine cutaneous epitheliotropic T-cell lymphoma: a review of 30 cases.

Journal: Veterinary dermatology 20100601

Title: Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1.

Journal: Leukemia 20100601

Title: A phase II study to evaluate the toxicity and efficacy of alternating CCNU and high-dose vinblastine and prednisone (CVP) for treatment of dogs with high-grade, metastatic or nonresectable mast cell tumours.

Journal: Veterinary and comparative oncology 20100601

Title: Vincristine in high-grade glioma.

Journal: Anticancer research 20100601

Title: The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing.

Journal: Toxicology letters 20100504

Title: Management of low-grade glioma.

Journal: Current neurology and neuroscience reports 20100501

Title: Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data.

Journal: Lancet (London, England) 20100410

Title: Apparent feline leukemia virus-induced chronic lymphocytic leukemia and response to treatment.

Journal: Journal of feline medicine and surgery 20100401

Title: Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100301

Title: IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100301

Title: Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice.

Journal: Neuro-oncology 20100301

Title: Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.

Journal: Bioorganic & medicinal chemistry 20100301

Title: Oral second- and third-line lomustine-etoposide-cyclophosphamide chemotherapy for small cell lung cancer.

Journal: Lung cancer (Amsterdam, Netherlands) 20100201

Title: Extended-schedule dose-dense temozolomide in refractory gliomas.

Journal: Journal of neuro-oncology 20100201

Title: The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20100201

Title: Protein tyrosine phosphatases in glioma biology.

Journal: Acta neuropathologica 20100201

Title: Bevacizumab is active as a single agent against recurrent malignant gliomas.

Journal: Anticancer research 20100201

Title: Effectiveness of temozolomide for primary glioblastoma multiforme in routine clinical practice.

Journal: Journal of neuro-oncology 20100101

Title: The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics.

Journal: Journal of neuro-oncology 20100101

Title: Intra-arterial chemotherapy with osmotic blood-brain barrier disruption for aggressive oligodendroglial tumors: results of a phase I study.

Journal: Neurosurgery 20100101

Title: Progress on antiangiogenic therapy for patients with malignant glioma.

Journal: Journal of oncology 20100101

Title: The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.

Journal: BMC cancer 20100101

Title: CyberKnife enhanced conventionally fractionated chemoradiation for high grade glioma in close proximity to critical structures.

Journal: Journal of hematology & oncology 20100101

Title: Health-related quality of life in glioma patients in China.

Journal: BMC cancer 20100101

Title: Mesenchymal migration as a therapeutic target in glioblastoma.

Journal: Journal of oncology 20100101

Title: Impact of adjuvant chemotherapy for gliomatosis cerebri.

Journal: BMC cancer 20100101

Title: Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept.

Journal: BMC cancer 20100101

Title: I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma.

Journal: Molecular cancer 20100101

Title: The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas.

Journal: BMC cancer 20100101

Title: Temozolomide in malignant glioma.

Journal: OncoTargets and therapy 20100101

Title: Malignant head and neck paragangliomas: is there an optimal treatment strategy?

Journal: Head & neck oncology 20100101

Title: Conversion of a molecular classifier obtained by gene expression profiling into a classifier based on real-time PCR: a prognosis predictor for gliomas.

Journal: BMC medical genomics 20100101

Title: High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study.

Journal: Journal of translational medicine 20100101

Title: Late onset of cerebellar abiotrophy in a boxer dog.

Journal: Veterinary medicine international 20100101

Title: Phase II, open-label trial of single-agent CCNU in dogs with previously untreated histiocytic sarcoma.

Journal: Journal of veterinary internal medicine 20100101

Title: Natural history and outcome of optic pathway gliomas in children.

Journal: Pediatric blood & cancer 20091215

Title: De novo germline TP53 mutation presenting with synchronous malignancies of the central nervous system.

Journal: Pediatric blood & cancer 20091215

Title: Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma.

Journal: British journal of cancer 20091215

Title: Anaplastic glioma: how to prognosticate outcome and choose a treatment strategy. [corrected].

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

Title: MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

Title: NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

Title: Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951.

Journal: Neuro-oncology 20091201

Title: Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)*.

Journal: Veterinary and comparative oncology 20091201

Title: Current data and strategy in glioblastoma multiforme.

Journal: Journal of medicine and life 20091115

Title: Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

Journal: Toxicology 20091109

Title: Assessment of cetuximab efficacy by bioluminescence monitoring of intracranial glioblastoma xenograft in mouse.

Journal: Journal of neuro-oncology 20091001

Title: Fotemustine as second-line treatment for recurrent or progressive glioblastoma after concomitant and/or adjuvant temozolomide: a phase II trial of Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).

Journal: Cancer chemotherapy and pharmacology 20090901

Title: Combined radio- and chemotherapy of brain tumours in adult patients.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20090901

Title: Combination CCNU and vinblastine chemotherapy for canine mast cell tumours: 57 cases.

Journal: Veterinary and comparative oncology 20090901

Title: [A multicenter randomized controlled study of temozolomide in 97 patients with malignant brain glioma].

Journal: Zhonghua yi xue za zhi 20090804

Title: Low-grade gliomas.

Journal: Current treatment options in oncology 20090801

Title: Immunotherapy of distant metastatic disease.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20090801

Title: Dose-modified oral chemotherapy in the treatment of AIDS-related non-Hodgkin's lymphoma in East Africa.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090720

Title: Non-pineal supratentorial primitive neuro-ectodermal tumors (sPNET) in teenagers and young adults: Time to reconsider cisplatin based chemotherapy after cranio-spinal irradiation?

Journal: Pediatric blood & cancer 20090701

Title: [Clinicopathological diagnosis of gliomas by genotype analysis].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20090701

Title: [Treatment of glioma with temozolomide].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20090701

Title: Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090601

Title: Long-term survival in dogs with localized histiocytic sarcoma treated with CCNU as an adjuvant to local therapy.

Journal: Veterinary and comparative oncology 20090601

Title: Disseminated histiocytic sarcoma with excessive hemophagocytosis in a cat.

Journal: The Journal of veterinary medical science 20090601

Title: Molecular markers of tumor progression in melanoma.

Journal: Current genomics 20090601

Title: Bevacizumab for recurrent alkylator-refractory anaplastic oligodendroglioma.

Journal: Cancer 20090415

Title: Long-term survival of patients with glioblastoma treated with radiotherapy and lomustine plus temozolomide.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090310

Title: ACNU-based chemotherapy for recurrent glioma in the temozolomide era.

Journal: Journal of neuro-oncology 20090301

Title: Canine cutaneous epitheliotropic T-cell lymphoma: a review.

Journal: Veterinary and comparative oncology 20090301

Title: Evaluation of dexamethasone as a chemoprotectant for CCNU-induced bone marrow suppression in dogs.

Journal: Veterinary and comparative oncology 20090301

Title: ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin's lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090210

Title: High-dose methotrexate combined with procarbazine and CCNU for primary CNS lymphoma in the elderly: results of a prospective pilot and phase II study.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20090201

Title: Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics.

Journal: Chemical communications (Cambridge, England) 20090107

Title: What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma.

Journal: Journal of neuro-oncology 20090101

Title: Increased degradation rate of nitrososureas in media containing carbonate.

Journal: In vitro cellular & developmental biology. Animal 20090101

Title: Long-term progression-free survival in metastatic uveal melanoma after chemoimmunotherapy and consolidation thermoablation.

Journal: Acta oncologica (Stockholm, Sweden) 20090101

Title: Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors.

Journal: Journal of the American Animal Hospital Association 20090101

Title: Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs.

Journal: Journal of veterinary internal medicine 20090101

Title: Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells.

Journal: Journal of translational medicine 20090101

Title: Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors.

Journal: PloS one 20090101

Title: Molecular neuropathology of gliomas.

Journal: International journal of molecular sciences 20090101

Title: Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation.

Journal: BMC cancer 20090101

Title: High specificity of quantitative methylation-specific PCR analysis for MGMT promoter hypermethylation detection in gliomas.

Journal: Journal of biomedicine & biotechnology 20090101

Title: Primary non-Hodgkin's lymphoma of the infratemporal fossa: a rare case report.

Journal: Head & neck oncology 20090101

Title: Retrospective analysis of treatment outcome in 315 patients with oligodendroglial brain tumors.

Journal: BMC neurology 20090101

Title: A homoharringtonine-based induction regimen for the treatment of elderly patients with acute myeloid leukemia: a single center experience from China.

Journal: Journal of hematology & oncology 20090101

Title: Combination chemotherapy with continuous L-asparaginase, lomustine, and prednisone for relapsed canine lymphoma.

Journal: Journal of veterinary internal medicine 20090101

Title: Current available therapies and future directions in the treatment of malignant gliomas.

Journal: Biologics : targets & therapy 20090101

Title: Nitroxyl radicals for labeling of conventional therapeutics and noninvasive magnetic resonance imaging of their permeability for blood-brain barrier: relationship between structure, blood clearance, and MRI signal dynamic in the brain.

Journal: Molecular pharmaceutics 20090101

Title: Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors.

Journal: Journal of translational medicine 20090101

Title: RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study.

Journal: BMC cancer 20090101

Title: Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains.

Journal: BMC microbiology 20090101

Title: Dose reductions of vincristine in children with medulloblastoma treated in the maintenance arm of the prospective multicenter trial HIT'91.

Journal: Klinische Padiatrie 20090101

Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

Journal: PloS one 20090101

Title: Recursive partitioning analysis of prognostic factors in WHO grade III glioma patients treated with radiotherapy or radiotherapy plus chemotherapy.

Journal: BMC cancer 20090101

Title: Synthesis of trans- and cis-4'-hydroxylomustine and development of validated analytical method for lomustine and trans- and cis-4'-hydroxylomustine in canine plasma.

Journal: Journal of analytical toxicology 20090101

Title: Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma.

Journal: Case reports in medicine 20090101

Title: Antiangiogenic therapy in the treatment of recurrent medulloblastoma in the adult: case report and review of the literature.

Journal: Journal of oncology 20090101

Title: Rational use of cetuximab in the treatment of advanced non-small cell lung cancer.

Journal: OncoTargets and therapy 20090101

Title: Temozolomide: The evidence for its therapeutic efficacy in malignant astrocytomas.

Journal: Core evidence 20090101

Title: New therapies for recurrent glioblastomas.

Journal: F1000 medicine reports 20090101

Title: Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations.

Journal: Cancer management and research 20090101

Title: Rates of inclusion of teenagers and young adults in England into National Cancer Research Network clinical trials: report from the National Cancer Research Institute (NCRI) Teenage and Young Adult Clinical Studies Development Group.

Journal: British journal of cancer 20081209

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Survival from brain tumours in England and Wales up to 2001.

Journal: British journal of cancer 20080923

Title: A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis.

Journal: Journal of neuro-oncology 20080901

Title: Treatment of Hodgkin lymphoma: the past, present, and future.

Journal: Nature clinical practice. Oncology 20080901

Title: Low-grade glioma: a challenge in therapeutic options: the role of radiotherapy.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20080901

Title: Chemotherapy and radiotherapy for treatment of cutaneous lymphoma in a ground cuscus (Phalanger gymnotis).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080901

Title: Cryptococcal meningitis in patients with glioma: a report of two cases.

Journal: Journal of neuro-oncology 20080801

Title: A phase I trial of temozolomide and lomustine in newly diagnosed high-grade gliomas of childhood.

Journal: Neuro-oncology 20080801

Title: In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

Journal: British journal of cancer 20080722

Title: Anaplastic oligodendroglioma.

Journal: Current treatment options in neurology 20080701

Title: Lessons from a time capsule: evolution, not revolution, in therapy for advanced non-small-cell lung cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080701

Title: Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells.

Journal: Cancer research 20080701

Title: Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study.

Journal: British journal of cancer 20080603

Title: Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat.

Journal: Veterinary and comparative oncology 20080601

Title: [Chemotherapy and renal toxicity].

Journal: Bulletin du cancer 20080528

Title: Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients.

Journal: Journal of neuro-oncology 20080501

Title: Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas.

Journal: The Cochrane database of systematic reviews 20080416

Title: High-dose chemotherapy with autologous stem cell transplantation in adults with recurrent embryonal tumors of the central nervous system.

Journal: Cancer 20080415

Title: Lomustine for treatment of mast cell tumors in cats: 38 cases (1999-2005).

Journal: Journal of the American Veterinary Medical Association 20080415

Title: Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells.

Journal: Journal of neuro-oncology 20080401

Title: Influence of therapy on the antioxidant status in patients with melanoma.

Journal: Journal of clinical pharmacy and therapeutics 20080401

Title: Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptides.

Journal: Biochemical and biophysical research communications 20080227

Title: A long-term durable remission with high-dose therapy and autologous stem cell transplant for stage IVB HIV-associated Hodgkins disease.

Journal: AIDS (London, England) 20080219

Title: A phase II study investigating the re-induction of endocrine sensitivity following chemotherapy in androgen-independent prostate cancer.

Journal: British journal of cancer 20080115

Title: Re-induction of hormone sensitivity to diethylstilboestrol in androgen refractory prostate cancer patients following chemotherapy.

Journal: British journal of cancer 20080115

Title: Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: elucidating the significance of systemic chemotherapy.

Journal: Oral oncology 20080101

Title: Complete response after treatment with a somatostatin analogue in an adult patient with recurrent medulloblastoma.

Journal: Acta oncologica (Stockholm, Sweden) 20080101

Title: Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma.

Journal: Neuro-oncology 20080101

Title: Combination of CCNU and DTIC chemotherapy for treatment of resistant lymphoma in dogs.

Journal: Journal of veterinary internal medicine 20080101

Title: Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling.

Journal: Cancer cell international 20080101

Title: Consultation within the nephroblastoma trial SIOP 2001/GPOH as part of the workload in the trial office.

Journal: Klinische Padiatrie 20080101

Title: Procarbazine--a traditional drug in the treatment of malignant gliomas.

Journal: Current medicinal chemistry 20080101

Title: Clinicopathological features and outcome for dogs with mast cell tumors and bone marrow involvement.

Journal: Journal of veterinary internal medicine 20080101

Title: Procarbazine and CCNU as initial treatment in gliomatosis cerebri.

Journal: Oncology 20080101

Title: Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age.

Journal: BMC medical genomics 20080101

Title: [Postoperative chemoradiotherapy for cerebral glioblastoma].

Journal: Voprosy onkologii 20080101

Title: [Clinical features and combined treatment of the central nervous system in Hodgkin's disease].

Journal: Voprosy onkologii 20080101

Title: Reinduction of bevacizumab in combination with pegylated liposomal Doxorubicin in a patient with recurrent glioblastoma multiforme who progressed on bevacizumab/irinotecan.

Journal: Journal of oncology 20080101

Title: A Single Institution's Experience with Bevacizumab in Combination with Cytotoxic Chemotherapy in Progressive Malignant Glioma.

Journal: Clinical medicine. Oncology 20080101

Title: Health-related quality of life in patients treated for anaplastic oligodendroglioma with adjuvant chemotherapy: results of a European Organisation for Research and Treatment of Cancer randomized clinical trial.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071220

Title: Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks.

Journal: Cancer research 20071215

Title: In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance.

Journal: British journal of pharmacology 20071201

Title: Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide.

Journal: Therapeutics and clinical risk management 20071201

Title: Diffuse glioma growth: a guerilla war.

Journal: Acta neuropathologica 20071101

Title: Molecular targeted therapies and chemotherapy in malignant gliomas.

Journal: Current opinion in oncology 20071101

Title: Anaplastic oligodendroglioma and oligoastrocytoma.

Journal: Neurologic clinics 20071101

Title: Adjuvant chemotherapy for adults with malignant glioma: a systematic review.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20071101

Title: Adding lomustine to idarubicin and cytarabine for induction chemotherapy in older patients with acute myeloid leukemia: the BGMT 95 trial results.

Journal: Haematologica 20071001

Title: Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas.

Journal: Therapeutics and clinical risk management 20071001

Title: Chemoradiotherapy in malignant glioma: standard of care and future directions.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070910

Title: A phase 2 feasibility study of sequential, dose intensive chemotherapy to treat progressive low-grade gliomas in children.

Journal: Journal of pediatric hematology/oncology 20070901

Title: Successful treatment with voriconazole of Aspergillus brain abscess in a boy with medulloblastoma.

Journal: Pediatric blood & cancer 20070801

Title: The 2007 WHO classification of tumours of the central nervous system.

Journal: Acta neuropathologica 20070801

Title: Effect of the spin-labelled 1-ethyl-1-nitrosourea on CCNU-induced oxidative liver injury.

Journal: Die Pharmazie 20070801

Title: Lomustine and prednisone as a first-line treatment for dogs with multicentric lymphoma: 17 cases (2004-2005).

Journal: Journal of the American Veterinary Medical Association 20070615

Title: Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling.

Journal: Mutation research 20070601

Title: Radiotherapy plus concurrent and adjuvant procarbazine, lomustine, and vincristine chemotherapy for patients with malignant glioma.

Journal: Oncology reports 20070601

Title: Canadian recommendations for the treatment of glioblastoma multiforme.

Journal: Current oncology (Toronto, Ont.) 20070601

Title: Treatment of malignant lymphoma in an African lion (Panthera leo).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20070601

Title: Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors.

Journal: Therapeutics and clinical risk management 20070601

Title: Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience.

Journal: Journal of neuro-oncology 20070501

Title: [Randomised phase II study evaluating oral combination chemotherapy (CCNU, cyclophosphamide, etoposide) and intravenous chemotherapy as second-line treatment for relapsed small cell bronchial carcinoma (Trial GFPC0501)].

Journal: Revue des maladies respiratoires 20070501

Title: The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas.

Journal: Journal of the National Cancer Institute 20070418

Title: Timing of radiation in children with medulloblastoma/PNET.

Journal: Pediatric blood & cancer 20070401

Title: Treatment of newly diagnosed symptomatic pure low-grade oligodendrogliomas with PCV chemotherapy.

Journal: European journal of neurology 20070401

Title: Chemotherapy for relapsed small cell lung cancer: a systematic review and practice guideline.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070401

Title: Dynamics of chemosensitivity and chromosomal instability in recurrent glioblastoma.

Journal: British journal of cancer 20070326

Title: Astrocytic tumors in children: treatment results from a single institution.

Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 20070301

Title: Subtypes of oligodendroglioma defined by 1p,19q deletions, differ in the proportion of apoptotic cells but not in replication-licensed non-proliferating cells.

Journal: Acta neuropathologica 20070201

Title: A phase I/II study of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma.

Journal: British journal of cancer 20070115

Title: LACE-conditioned autologous stem cell transplantation for relapsed or refractory Hodgkin's lymphoma: treatment outcome and risk factor analysis in 67 patients from a single centre.

Journal: Bone marrow transplantation 20070101

Title: CCNU for the treatment of dogs with histiocytic sarcoma.

Journal: Journal of veterinary internal medicine 20070101

Title: Combination chemotherapy with L-asparaginase, lomustine, and prednisone for relapsed or refractory canine lymphoma.

Journal: Journal of veterinary internal medicine 20070101

Title: Serum VEGF-C is associated with metastatic site in patients with malignant melanoma.

Journal: Acta oncologica (Stockholm, Sweden) 20070101

Title: Impact of phase II trials with progression-free survival as end-points on survival-based phase III studies in patients with anaplastic gliomas.

Journal: BMC cancer 20070101

Title: Overexpressed TP73 induces apoptosis in medulloblastoma.

Journal: BMC cancer 20070101

Title: Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds.

Journal: Acta poloniae pharmaceutica 20070101

Title: Radiotherapeutic alternatives for previously irradiated recurrent gliomas.

Journal: BMC cancer 20070101

Title: Gene signatures developed from patient tumor explants grown in nude mice to predict tumor response to 11 cytotoxic drugs.

Journal: Cancer genomics & proteomics 20070101

Title: Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma.

Journal: Journal of translational medicine 20070101

Title: Comparison of 3 protocols for treatment after induction of remission in dogs with lymphoma.

Journal: Journal of veterinary internal medicine 20070101

Title: DNA-metallodrugs interactions signaled by electrochemical biosensors: an overview.

Journal: Bioinorganic chemistry and applications 20070101

Title: [Clinical significance of mustoforan in management of malignant glioma].

Journal: Voprosy onkologii 20070101

Title: [Analysis of selected undesirable effects of cytostatic drugs in treatment of the central nervous system tumours in children. Preliminary report].

Journal: Medycyna wieku rozwojowego 20070101

Title: Targeted brain tumor treatment-current perspectives.

Journal: Drug target insights 20070101

Title: Cooperative activity of cytotoxic chemotherapy with antiangiogenic thrombospondin-I peptides, ABT-526 in pet dogs with relapsed lymphoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061215

Title: Effects of lipid association on lomustine (CCNU) administered intracerebrally to syngeneic 36B-10 rat brain tumors.

Journal: Cancer letters 20061208

Title: Late response to radiochemotherapy in pediatric glioblastoma: report on two patients treated according to HIT-GBM protocols.

Journal: Pediatric hematology and oncology 20061201

Title: New methods for direct delivery of chemotherapy for treating brain tumors.

Journal: The Yale journal of biology and medicine 20061201

Title: Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms.

Journal: British journal of cancer 20061120

Title: Chemotherapy for primary central nervous system lymphoma.

Journal: Neurosurgical focus 20061115

Title: [Long-term outcome in patients with symptomatic low-grade oligodendrogliomatous tumors treated by cytotoxic agents].

Journal: Revue neurologique 20061101

Title: Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog.

Journal: The Journal of veterinary medical science 20061101

Title: [Small cell lung cancer (CPC). Second line treatment].

Journal: Revue des maladies respiratoires 20061101

Title: Secondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas.

Journal: British journal of cancer 20061023

Title: Cerebral blood volume, genotype and chemosensitivity in oligodendroglial tumours.

Journal: Neuroradiology 20061001

Title: Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060920

Title: A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase.

Journal: Cancer gene therapy 20060901

Title: Phase II study of mitomycin-C, adriamycin, cisplatin (MAP) and Bleomycin-CCNU in patients with advanced cancer of the anal canal: An eastern cooperative oncology group study E7282.

Journal: Investigational new drugs 20060901

Title: Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060901

Title: Diagnosis and treatment of a feline oral mast cell tumor.

Journal: Journal of feline medicine and surgery 20060801

Title: Lomustine for the treatment of gastrointestinal mast cell tumour in a dog.

Journal: The Journal of small animal practice 20060801

Title: Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma.

Journal: Neuro-oncology 20060701

Title: Anaplastic oligodendroglial tumors: a tale of two trials.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620

Title: Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620

Title: Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060620

Title: Clinical use of genotype to predict chemosensitivity in oligodendroglial tumors.

Journal: Neurology 20060613

Title: Gliomatosis cerebri treatment in 11 elderly patients.

Journal: Journal of experimental & clinical cancer research : CR 20060601

Title: Re-evaluation of the cost effectiveness of temozolomide for malignant gliomas in British Columbia.

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20060601

Title: [Palliative therapy in glioblastoma multiforme: a multimodal concept].

Journal: Wiener medizinische Wochenschrift (1946) 20060501

Title: High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma: long-term follow-up.

Journal: Neuro-oncology 20060401

Title: Long-term chemotherapy with lomustine of intracranial meningioma occurring in a miniature schnauzer.

Journal: The Journal of veterinary medical science 20060401

Title: Mitoxantrone, vinblastine and CCNU: long-term follow-up of patients treated for advanced and poor-prognosis Hodgkin's disease.

Journal: Leukemia & lymphoma 20060401

Title: Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy.

Journal: International journal of radiation oncology, biology, physics 20060315

Title: Current strategies in treatment of oligodendroglioma: evolution of molecular signatures of response.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060310

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060301

Title: PCV chemotherapy for recurrent glioblastoma.

Journal: Neurology 20060227

Title: Changing paradigms--an update on the multidisciplinary management of malignant glioma.

Journal: The oncologist 20060201

Title: Toxic epidermal necrolysis after PCV combination chemotherapy for relapsed B-cell lymphoma.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20060201

Title: Oligodendroglial tumor chemotherapy using 'decreased-dose-intensity' PCV: a Singapore experience.

Journal: Neurology 20060124

Title: MOPPEBVCAD chemotherapy with limited and conditioned radiotherapy in advanced Hodgkin's lymphoma: 10-year results, late toxicity, and second tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060115

Title: Phase I study of temozolomide and lomustine in the treatment of high grade malignant glioma.

Journal: Frontiers in bioscience : a journal and virtual library 20060101

Title: CCNU in the treatment of canine epitheliotropic lymphoma.

Journal: Journal of veterinary internal medicine 20060101

Title: Solitary pulmonary metastasis from primary melanoma of the oesophagus 5 years after resection of the primary tumor.

Journal: World journal of surgical oncology 20060101

Title: Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma.

Journal: BMC cancer 20060101

Title: Treatments for astrocytic tumors in children: current and emerging strategies.

Journal: Paediatric drugs 20060101

Title: Hospital in the home (HITH) care following autologous stem cell transplantation for lymphoma and multiple myeloma.

Journal: The Australian journal of advanced nursing : a quarterly publication of the Royal Australian Nursing Federation 20060101

Title: Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.

Journal: BMC cancer 20060101

Title: CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo.

Journal: Journal of biology 20060101

Title: Response of canine cutaneous epitheliotropic lymphoma to lomustine (CCNU): a retrospective study of 46 cases (1999-2004).

Journal: Journal of veterinary internal medicine 20060101

Title: ABVD versus modified stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate- and advanced-stage Hodgkin's lymphoma: final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051220

Title: Phase II study of high-dose chemotherapy before radiation in children with newly diagnosed high-grade astrocytoma: final analysis of Children's Cancer Group Study 9933.

Journal: Cancer 20051215

Title: Procarbazine, lomustine, vincristine combination may be effective in adult medulloblastoma patients with systemic metastases.

Journal: Journal of neuro-oncology 20051101

Title: Liposome-mediated transfection of mature taste cells.

Journal: Journal of neurobiology 20051001

Title: Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action.

Journal: Journal of biotechnology 20050929

Title: Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies.

Journal: British journal of cancer 20050905

Title: Ependymal tumors in childhood.

Journal: Pediatric blood & cancer 20050901

Title: Complete remission of brain metastases in three patients with stage IV melanoma treated with BOLD and G-CSF.

Journal: Japanese journal of clinical oncology 20050901

Title: Salvage therapy of progressive and recurrent Hodgkin's disease: results from a multicenter study of the pediatric DAL/GPOH-HD study group.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050901

Title: Oral combination chemotherapy in the treatment of AIDS-associated Hodgkin's disease.

Journal: East African medical journal 20050901

Title: Randomized trial of dacarbazine versus bleomycin, vincristine, lomustine and dacarbazine (BOLD) chemotherapy combined with natural or recombinant interferon-alpha in patients with advanced melanoma.

Journal: Melanoma research 20050801

Title: Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050715

Title: Beneficial effects of spin-labelled nitrosourea on CCNU-induced oxidative stress in rat blood compared with vitamin E.

Journal: Die Pharmazie 20050701

Title: [Favourable result for temozolomide in recurrent high-grade glioma].

Journal: Nederlands tijdschrift voor geneeskunde 20050618

Title: Survival of adults treated for medulloblastoma using paediatric protocols.

Journal: European journal of cancer (Oxford, England : 1990) 20050601

Title: Role of novel targeted therapies in the clinic.

Journal: British journal of cancer 20050601

Title: Lomustine (chloroethylnitrosourea [CCNU]), ifosfamide, bleomycin, vincristine, and cisplatin (CIBO-P) is an effective regimen for patients with poor prognostic refractory or multiple disease recurrent aggressive non-Hodgkin lymphoma.

Journal: Cancer 20050515

Title: P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy.

Journal: Journal of neuro-oncology 20050501

Title: [Brief review of the neuro oncology for recent three decades in Japan].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20050401

Title: Re-induction of hormonal sensitivity in hormone-refractory prostate cancer--fact or fiction?

Journal: Nature clinical practice. Oncology 20050401

Title: Therapeutic effects of Holmium-166 chitosan complex in rat brain tumor model.

Journal: Yonsei medical journal 20050227

Title: Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine.

Journal: Cancer 20050215

Title: Non-small-cell lung cancer in a French department, (1982-1997): management and outcome.

Journal: British journal of cancer 20050214

Title: Chlorambucil and lomustine (CL56) in absolute hormone refractory prostate cancer: re-induction of endocrine sensitivity an unexpected finding.

Journal: British journal of cancer 20050117

Title: Use of lomustine to treat cutaneous nonepitheliotropic lymphoma in a cat.

Journal: Journal of the American Veterinary Medical Association 20050115

Title: Semi-quantification of methionine uptake and flair signal for the evaluation of chemotherapy in low-grade oligodendroglioma.

Journal: Journal of neuro-oncology 20050101

Title: Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma.

Journal: Neuro-oncology 20050101

Title: Combination chemotherapy with carmustine and cisplatin followed by procarbazine, lomustine, and vincristine for adult high-grade astrocytoma.

Journal: Chang Gung medical journal 20050101

Title: Economic evaluation of temozolomide in the treatment of recurrent glioblastoma multiforme.

Journal: PharmacoEconomics 20050101

Title: Assay of CCNU in tumor by RP-HPLC.

Journal: Artificial cells, blood substitutes, and immobilization biotechnology 20050101

Title: Long-term disease-free survival in advanced melanomas treated with nitrosoureas: mechanisms and new perspectives.

Journal: BMC cancer 20050101

Title: Treatment of patients of high-risk group of medulloblastoma with the adjuvant lomustine, cisplatin, and vincristine chemotherapy.

Journal: Medicina (Kaunas, Lithuania) 20050101

Title: Antitumor activity of Nitronaphthal-NU, a novel mixed-function agent.

Journal: Journal of experimental therapeutics & oncology 20050101

Title: [Results of hyperfractionated radiation therapy used in combination with lomustin in malignant gliomas of the brain].

Journal: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 20050101

Title: Amifostine for children with medulloblastoma treated with cisplatin-based chemotherapy.

Journal: Pediatric blood & cancer 20041201

Title: Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity.

Journal: Journal of neurochemistry 20041201

Title: The prognostic role of CD4+ and CD8+ lymphocytes during chemoimmunotherapy in metastatic melanoma.

Journal: Melanoma research 20041201

Title: Metastatic glioblastoma in cervical lymph node after repeated craniotomies: report of a case with diagnosis by fine needle aspiration.

Journal: Journal of Korean medical science 20041201

Title: Efficacy and feasibility of standard procarbazine, lomustine, and vincristine chemotherapy in anaplastic oligodendroglioma and oligoastrocytoma recurrent after radiotherapy. A Phase II study.

Journal: Cancer 20041101

Title: Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study.

Journal: British journal of cancer 20041101

Title: [Therapeutic efficacy of hematopoietic stem cell transplantation in patients with chronic myelogenous leukemia].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20041101

Title: Diagnosis and management of oligodendroglioma.

Journal: Seminars in oncology 20041001

Title: Current controversies in the radiotherapeutic management of adult low-grade glioma.

Journal: Seminars in oncology 20041001

Title: [The molecular genetics of oligodendroglioma].

Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology 20041001

Title: Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas.

Journal: Neurology 20040914

Title: Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs.

Journal: International journal of cancer 20040910

Title: Multi-institutional phase II trial of irinotecan, cisplatin, and etoposide for sensitive relapsed small-cell lung cancer.

Journal: British journal of cancer 20040816

Title: Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.

Journal: Neurology 20040810

Title: Gliomatosis cerebri: better definition, better treatment.

Journal: Neurology 20040727

Title: Initial chemotherapy in gliomatosis cerebri.

Journal: Neurology 20040727

Title: Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study.

Journal: International journal of radiation oncology, biology, physics 20040601

Title: Intrinsic brainstem choroid plexus papilloma. Case report.

Journal: Journal of neurosurgery 20040601

Title: Long-term outcome of oligodendrogliomas.

Journal: Neurology 20040525

Title: [Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults].

Journal: Revue neurologique 20040501

Title: Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice.

Journal: British journal of cancer 20040419

Title: Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404.

Journal: International journal of radiation oncology, biology, physics 20040315

Title: Concurrent chemotherapy and reduced-dose cranial spinal irradiation followed by conformal posterior fossa tumor bed boost for average-risk medulloblastoma: efficacy and patterns of failure.

Journal: International journal of radiation oncology, biology, physics 20040315

Title: Salvage chemotherapy with cyclophosphamide for recurrent, temozolomide-refractory glioblastoma multiforme.

Journal: Cancer 20040315

Title: Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1.

Journal: British journal of pharmacology 20040301

Title: Second-line treatment with carboplatin for recurrent or progressive oligodendroglial tumors after PCV (procarbazine, lomustine, and vincristine) chemotherapy: a phase II study.

Journal: Cancer 20040215

Title: Monitoring individual response to brain-tumour chemotherapy: proton MR spectroscopy in a patient with recurrent glioma after stereotactic radiotherapy.

Journal: Neuroradiology 20040201

Title: Second malignancies after chemotherapy and radiotherapy for Hodgkin disease.

Journal: American journal of clinical oncology 20040201

Title: Chemotherapy of anaplastic oligodendroglial tumours.

Journal: Expert opinion on pharmacotherapy 20040201

Title: Molecular genetic study of a metastatic oligodendroglioma.

Journal: Journal of neuro-oncology 20040201

Title: Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs.

Journal: Journal of veterinary internal medicine 20040101

Title: Metastatic lung disease to the central nervous system: in vitro response to chemotherapeutic agents.

Journal: Journal of neuro-oncology 20040101

Title: Human osteosarcoma xenografts and their sensitivity to chemotherapy.

Journal: Pathology oncology research : POR 20040101

Title: Preradiation chemotherapy with VM-26 and CCNU in patients with glioblastoma multiforme.

Journal: Tumori 20040101

Title: Overdose of lomustine: report of two cases.

Journal: Tumori 20040101

Title: The toxicological study of CCNU controlled release film in vivo.

Journal: Artificial cells, blood substitutes, and immobilization biotechnology 20040101

Title: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea.

Journal: Report on carcinogens : carcinogen profiles 20040101

Title: Oligodendroglioma.

Journal: Current treatment options in oncology 20031201

Title: Medulloblastomas and central nervous system primitive neuroectodermal tumors.

Journal: Current treatment options in oncology 20031201

Title: Systemic chemotherapy in the treatment of malignant melanoma.

Journal: Expert opinion on pharmacotherapy 20031201

Title: The role of PCV chemotherapy in the treatment of central neurocytoma: illustration of a case and review of the literature.

Journal: Surgical neurology 20031201

Title: [Suppression of nitric oxide on cytotoxicity of Lomustine in glioma cell line BT- 325].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031201

Title: The treatment of elderly patients with high-grade gliomas.

Journal: Seminars in oncology 20031201

Title: Promising survival for patients with glioblastoma multiforme treated with individualised chemotherapy based on in vitro drug sensitivity testing.

Journal: British journal of cancer 20031117

Title: Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis.

Journal: Surgical neurology 20031101

Title: High-dose chemotherapy with stem cell rescue as initial therapy for anaplastic oligodendroglioma.

Journal: Journal of neuro-oncology 20031101

Title: Spin labeled antioxidants protect bacteria against the toxicity of alkylating antitumor drug CCNU.

Journal: Toxicology letters 20031015

Title: Adult height and adult sitting height in childhood medulloblastoma survivors.

Journal: The Journal of clinical endocrinology and metabolism 20031001

Title: Outcome of children with centrally reviewed low-grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high-grade glioma study CCG-945.

Journal: Cancer 20030915

Title: Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents.

Journal: Cancer chemotherapy and pharmacology 20030901

Title: First European case of serotype A MATa Cryptococcus neoformans infection.

Journal: Emerging infectious diseases 20030901

Title: Dramatic response to chemotherapy in oligodendroglial gliomatosis cerebri.

Journal: Neurology 20030812

Title: Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin.

Journal: British journal of cancer 20030804

Title: Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy.

Journal: Annals of diagnostic pathology 20030801

Title: Summary version of the Standards, Options and Recommendations for the management of adult patients with intracranial glioma (2002).

Journal: British journal of cancer 20030801

Title: Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.

Journal: British journal of cancer 20030721

Title: Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: a multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030715

Title: Phase II study of first-line chemotherapy with temozolomide in recurrent oligodendroglial tumors: the European Organization for Research and Treatment of Cancer Brain Tumor Group Study 26971.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030701

Title: Tolerance of nitrosurea-based multiagent chemotherapy regime for low-grade pediatric gliomas.

Journal: Journal of neuro-oncology 20030701

Title: Primary leptomeningeal primitive neuroectodermal tumor.

Journal: Journal of neuro-oncology 20030701

Title: [Acute myeloblastic leukemia in adults: evaluation of the AML 06/96 protocol].

Journal: La Tunisie medicale 20030701

Title: Survival improvement in patients with glioblastoma multiforme during the last 20 years in a single tertiary-care center.

Journal: Wiener klinische Wochenschrift 20030624

Title: High-dose therapy and autologous stem-cell transplantation versus conventional therapy for patients with advanced Hodgkin's lymphoma responding to front-line therapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030615

Title: Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030601

Title: Conformal irradiation for pure and mixed oligodendroglioma: the experience of Centre Leon Berard Lyon.

Journal: International journal of radiation oncology, biology, physics 20030501

Title: Irinotecan in the treatment of glioma patients: current and future studies of the North Central Cancer Treatment Group.

Journal: Cancer 20030501

Title: Bleomycin, vincristine, lomustine and dacarbazine (BOLD) in combination with recombinant interferon alpha-2b for metastatic uveal melanoma.

Journal: European journal of cancer (Oxford, England : 1990) 20030501

Title: Combined modality therapy for poorly differentiated gliomas of the posterior fossa in children: a Children's Cancer Group report.

Journal: Journal of neuro-oncology 20030501

Title: New chemotherapy agents in veterinary medicine.

Journal: The Veterinary clinics of North America. Small animal practice 20030501

Title: Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20030401

Title: Partially successful treatment of a patient with chronic lymphocytic leukemia and Hodgkin's disease: case report and literature review.

Journal: American journal of hematology 20030401

Title: Recent developments in the molecular characterization and treatment of oligodendroglial tumors.

Journal: Neuro-oncology 20030401

Title: Survival and prognostic factors of patients with unresectable glioblastoma multiforme.

Journal: Anti-cancer drugs 20030401

Title: Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial.

Journal: Melanoma research 20030401

Title: Interobserver variability in the radiological assessment of response to chemotherapy in glioma.

Journal: Neurology 20030311

Title: Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap.

Journal: Pediatric hematology and oncology 20030301

Title: Glioma treatment, radionecrosis, and growth factors. In regard to Levin et al., IJROBP 2002;53:58-66.

Journal: International journal of radiation oncology, biology, physics 20030301

Title: Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features.

Journal: Cancer 20030301

Title: Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030301

Title: Genetic alterations of human brain tumors as molecular prognostic factors.

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology 20030301

Title: Survival with dacarbazine and fotemustine in newly diagnosed glioblastoma multiforme.

Journal: British journal of cancer 20030224

Title: A prospective study on glioblastoma in the elderly.

Journal: Cancer 20030201

Title: Feasibility and toxicity of CCNU therapy in elderly patients with glioblastoma multiforme.

Journal: Anti-cancer drugs 20030201

Title: Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030115

Title: Dramatic response to chemotherapy in oligodendroglial gliomatosis cerebri.

Journal: Neurology 20030114

Title: Primary intraspinal primitive neuroectodermal tumor: report of two cases and review of the literature.

Journal: Journal of neuro-oncology 20030101

Title: Current chemotherapy for glioblastoma.

Journal: Cancer journal (Sudbury, Mass.) 20030101

Title: Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience.

Journal: Pediatric hematology and oncology 20030101

Title: Chemotherapy versus best supportive care for extensive small cell lung cancer.

Journal: The Cochrane database of systematic reviews 20030101

Title: [Use of modern technologies in the diagnosis and combined treatment of brain stem tumors].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101

Title: Medication sheets for patients. Oral chemotherapy.

Journal: Clinical journal of oncology nursing 20030101

Title: Guidelines for the treatment of adult intra-cranial grade II-III ependymal tumours.

Journal: Forum (Genoa, Italy) 20030101

Title: An elevated serum beta-2-microglobulin level is an adverse prognostic factor for overall survival in patients with early-stage Hodgkin disease.

Journal: Cancer 20021215

Title: Recurrent malignant glioma in adults.

Journal: Current treatment options in oncology 20021201

Title: Chemoimmunotherapy with bleomycin, vincristine, lomustine, dacarbazine (BOLD), and human leukocyte interferon for metastatic uveal melanoma.

Journal: Cancer 20021201

Title: Pulmonary complications in survivors of childhood and adolescent cancer. A report from the Childhood Cancer Survivor Study.

Journal: Cancer 20021201

Title: Coeliac disease following high-dose chemotherapy.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20021201

Title: Acute diarrhea during adjuvant therapy for rectal cancer: a detailed analysis from a randomized intergroup trial.

Journal: International journal of radiation oncology, biology, physics 20021001

Title: Phase I study of fotemustine in pediatric patients with refractory brain tumors.

Journal: Cancer 20020915

Title: Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis.

Journal: Cancer 20020901

Title: Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate.

Journal: Journal of neuro-oncology 20020901

Title: Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020801

Title: Treatment of advanced neuroendocrine tumours using combination chemotherapy with lomustine and 5-fluorouracil.

Journal: Clinical endocrinology 20020801

Title: Intensified PCV-chemotherapy with optional stem cell support in recurrent malignant oligodendroglioma.

Journal: Journal of neurology 20020801

Title: Treatment of intracranial metastatic esthesioneuroblastoma.

Journal: Cancer 20020715

Title: Long-term follow-up in managing anaplastic astrocytoma by multimodality approach with surgery followed by postoperative radiotherapy and PCV-chemotherapy: phase II trial.

Journal: American journal of clinical oncology 20020601

Title: Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma.

Journal: Cancer research 20020501

Title: Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas.

Journal: International journal of radiation oncology, biology, physics 20020501

Title: [Chemo-radiotherapy for malignant brain tumors].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20020501

Title: NO-mediated chemoresistance in C6 glioma cells.

Journal: Annals of the New York Academy of Sciences 20020501

Title: Concurrent modified PCV chemotherapy and radiotherapy in newly diagnosed grade IV astrocytoma.

Journal: Journal of neuro-oncology 20020501

Title: 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop.

Journal: Genes, chromosomes & cancer 20020401

Title: Structure-based design of nitrosoureas containing tyrosine derivatives as potential antimelanoma agents.

Journal: European journal of medicinal chemistry 20020401

Title: Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase.

Journal: Cancer research 20020315

Title: Evaluation of naphthal-NU, a 2-chloroethylnitrosourea derivative of naphthalimide, as a mixed-function anticancer agent.

Journal: Journal of experimental & clinical cancer research : CR 20020301

Title: High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.

Journal: International journal of cancer 20020201

Title: Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood: results of the prospective German brain tumor trials HIT 88/89 and 91.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020201

Title: Treatment of intracranial metastatic esthesioneuroblastoma.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020101

Title: Preradiation chemotherapy for pediatric patients with high-grade glioma.

Journal: Cancer 20020101

Title: Study of three hepatobiliary agents in experimental animals.

Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20020101

Title: Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: critical assessment of a practical dosing regimen.

Journal: Journal of the American Animal Hospital Association 20020101

Title: Radiotherapy alone for lymphocyte-predominant Hodgkin's disease.

Journal: Cancer journal (Sudbury, Mass.) 20020101

Title: [Role of adjuvant chemotherapy in the treatment of medulloblastoma in children].

Journal: Voprosy onkologii 20020101

Title: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea.

Journal: Report on carcinogens : carcinogen profiles 20020101

Title: Adults with newly diagnosed high-grade gliomas.

Journal: Current treatment options in oncology 20011201

Title: Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: clinical results.

Journal: International journal of radiation oncology, biology, physics 20011115

Title: The effectiveness of the O(6)-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O(6)-benzylguanine and sensitisation to dibromoalkane genotoxicity.

Journal: Mutation research 20011018

Title: Medical Research Council adjuvant trial in high-grade gliomas.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20011001

Title: Pilot evaluation of 1p and 19q deletions in anaplastic oligodendrogliomas collected by a national cooperative cancer treatment group.

Journal: American journal of clinical oncology 20011001

Title: PCV chemotherapy for oligodendroglioma: response analyzed on T2 weighted-MRI.

Journal: Journal of neuro-oncology 20011001

Title: Nitric oxide and free stable nitroxyl radicals in the mechanism of biological action of the spin-labeled compounds.

Journal: Medical hypotheses 20010901

Title: Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy.

Journal: International journal of radiation oncology, biology, physics 20010801

Title: PCV for oligodendroglial tumors: in search of prognostic factors for response and survival.

Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20010801

Title: Melanoma-associated retinopathy: does autoimmunity prolong survival?

Journal: Clinical & experimental ophthalmology 20010801

Title: Chemotherapy for the treatment of oligodendroglial tumors.

Journal: Seminars in oncology 20010801

Title: Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU.

Journal: Cancer gene therapy 20010801

Title: Two glycine containing 2-chloroethylnitrosoureas--a comparative study on some physicochemical properties, in vivo antimelanomic effects and immunomodulatory properties.

Journal: International journal of pharmaceutics 20010717

Title: CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release.

Journal: Oncogene 20010712

Title: Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones.

Journal: European journal of haematology 20010701

Title: Retrolective cohort study of an additive therapy with an oral enzyme preparation in patients with multiple myeloma.

Journal: Cancer chemotherapy and pharmacology 20010701

Title: PCV chemotherapy for recurrent glioblastoma multiforme.

Journal: Neurology 20010626

Title: Bleomycin, methotrexate, and CCNU in locally advanced or recurrent, inoperable, squamous-cell carcinoma of the vulva: an EORTC Gynaecological Cancer Cooperative Group Study. European Organization for Research and Treatment of Cancer.

Journal: Gynecologic oncology 20010601

Title: Lipid association improves the therapeutic index of lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea] to suppress 36B-10 tumor growth in rats.

Journal: Cancer research 20010501

Title: Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010501

Title: Inducible nitric oxide synthase neutralizes carbamoylating potential of 1,3-bis(2-chloroethyl)-1-nitrosourea in c6 glioma cells.

Journal: The Journal of pharmacology and experimental therapeutics 20010401

Title: Chemotherapy of low-grade gliomas.

Journal: Seminars in radiation oncology 20010401

Title: Multidisciplinary management of adult anaplastic oligodendrogliomas and anaplastic mixed oligo-astrocytomas.

Journal: Seminars in radiation oncology 20010401

Title: [Post-operative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of German prospective randomised trial HIT'91].

Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20010401

Title: APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis.

Journal: Cell death and differentiation 20010401

Title: Oral combination chemotherapy in conjunction with filgrastim (G-CSF) in the treatment of AIDS-related non-Hodgkin's lymphoma: evaluation of the role of G-CSF; quality-of-life analysis and long-term follow-up.

Journal: American journal of hematology 20010301

Title: Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells.

Journal: Gene therapy 20010301

Title: [Therapeutic effect on glioblastoma of chemotherapy on the basis of brain irradiation].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20010301

Title: Incidence, cost, and outcomes of bleeding and chemotherapy dose modification among solid tumor patients with chemotherapy-induced thrombocytopenia.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010215

Title: Recurrent intracranial ependymoma in children: salvage therapy with oral etoposide.

Journal: Pediatric neurology 20010201

Title: Spin labelled nitrosoureas and triazenes and their non-labelled clinically used analogues--a comparative study on their physicochemical properties and antimelanomic effects.

Journal: International journal of pharmaceutics 20010116

Title: Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010115

Title: PCV chemotherapy for recurrent glioblastoma multiforme.

Journal: Neurology 20010109

Title: Radiotherapy of esthesioneuroblastoma.

Journal: International journal of radiation oncology, biology, physics 20010101

Title: Multiple myeloma in elderly patients: presenting features and outcome.

Journal: European journal of haematology 20010101

Title: Adult medulloblastoma: multiagent chemotherapy.

Journal: Neuro-oncology 20010101

Title: Phase I evaluation of CCNU (lomustine) in tumor-bearing cats.

Journal: Journal of veterinary internal medicine 20010101

Title: Bleomycin, lomustine, cyclophosphamide, vincristine, procarbazine and prednisone (BLEO-CCVPP) in patients with Hodgkin's disease who relapsed after radiotherapy alone: a long-term follow-up study of the Eastern Cooperative Oncology Group (E3481).

Journal: Leukemia & lymphoma 20010101

Title: Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.

Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20010101

Title: Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics.

Journal: Anti-cancer drug design 20010101

Title: A possible correlation between unscheduled DNA repair and cholesterolemia in Wistar rat, modulated by vitamin E.

Journal: Roumanian archives of microbiology and immunology 20010101

Title: Venoocclusive liver disease (VOD) as a complication of Wilms' tumour management in the series of consecutive 206 patients.

Journal: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie 20001001

Title: Myeloablative chemotherapy for recurrent aggressive oligodendroglioma.

Journal: Neuro-oncology 20000401

Title: Synchronous radiochemotherapy in unfavorable brain tumors of children and young adults.

Journal: Journal of neuro-oncology 19980801

Title: Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19941001

Title: Aplastic anemia induced by cyclohexylchloroethylnitrousurea.

Journal: Anti-cancer drugs 19940201

Title: Cardiorespiratory decompensation following methylprednisolone administration.

Journal: Pediatric hematology and oncology 19930101

Title: Acute cerebral oedema induced by methotrexate.

Journal: BMJ (Clinical research ed.) 19890513

Title: CCNU-adriamycin association induces earlier and more severe nephropathy in rats.

Journal: Archives of toxicology 19880101

Title: Chemotherapy for adenocarcinoma of the lung (WHO III): A randomized study of vindesine versus lomustine, cyclophosphamide, and methotrexate versus all four drugs.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 19870801

Title: Sudden onset of blindness in patients treated with oral CCNU and low-dose cranial irradiation.

Journal: Cancer 19870301

Title: Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital.

Journal: Cancer chemotherapy and pharmacology 19870101

Title: Misonidazole-induced chemopotentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea toxicity in O6-methylguanine-DNA methyltransferase proficient (Mer+) and deficient (Mer-) cell lines.

Journal: Cancer research 19860601

Title: [Vipoma. 9-year observations using currently available therapy methods].

Journal: Deutsche medizinische Wochenschrift (1946) 19860221

Title: Cardiotoxicity as a result of 5-fluorouracil therapy.

Journal: Tumori 19850227

Title: Nephrotoxicity of lomustine. A case report and literature review.

Journal: Cancer chemotherapy and pharmacology 19850101

Title: Combination chemotherapy for advanced Hodgkin's disease after failure of MOPP: ABVD and B-CAVe.

Journal: Annals of internal medicine 19841001

Title: Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.

Journal: British journal of cancer 19830501

Title: Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine.

Journal: Cancer treatment reports 19830301

Title: Psychological response of patients receiving two drug regimens for lung carcinoma.

Journal: The American journal of psychiatry 19830101

Title: Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU.

Journal: British journal of cancer 19820801

Title: Enhancement by electron-affinic agents of the therapeutic effects of cytotoxic agents against the KHT tumor: structure-activity relationships.

Journal: International journal of radiation oncology, biology, physics 19820101

Title: Nephrotoxicity of nitrosoureas.

Journal: Cancer 19810915

Title: [Chronic renal failure after CCNU treatment (author's transl)].

Journal: La Nouvelle presse medicale 19801101

Title: Cardiotoxicity of 5-fluorouracil.

Journal: Tumori 19801031

Title: CCNU nephrotoxicity following sustained remission in oat cell carcinoma.

Journal: Cancer treatment reports 19790201

Title: Single-agent chemotherapy of brain tumors. A five-year review.

Journal: Archives of neurology 19761101

Title: Chemotherapeutic effects of some alkylating derivatives of nitrosourea on the development of tumors transplacentally induced in rats by ENU.

Journal: Acta neuropathologica 19760131

Title: Graft versus leukemia. VI. Adoptive immunotherapy in combination with chemoradiotherapy for spontaneous leukemia-lymphoma in AKR mice.

Journal: Journal of the National Cancer Institute 19751101

Title: Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma.

Journal: Cancer 19720801

Title: Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361.

Title: Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56.

Title: Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:13010-47-4 Molecular Formula|13010-47-4 MDL|13010-47-4 SMILES|13010-47-4 Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-