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130477-52-0,MFCD02684528
Catalog No.:AA000UE3

130477-52-0 | L-655708

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5mg
≥98%
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$152.00   $106.00
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10mg
≥98%
in stock  
$239.00   $167.00
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25mg
≥98%
in stock  
$445.00   $311.00
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50mg
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$815.00   $570.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000UE3
Chemical Name:
L-655708
CAS Number:
130477-52-0
Molecular Formula:
C18H19N3O4
Molecular Weight:
341.3612
MDL Number:
MFCD02684528
SMILES:
CCOC(=O)c1ncn2c1[C@@H]1CCCN1C(=O)c1c2ccc(c1)OC
Properties
Computed Properties
 
Complexity:
542  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
4  
XLogP3:
1.8  

Literature

Title: Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia.

Journal: Anesthesia and analgesia 20120401

Title: Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.

Journal: Bioorganic & medicinal chemistry 20120315

Title: Neurosteroid modulation of benzodiazepine-sensitive GABAA tonic inhibition in supraoptic magnocellular neurons.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20110601

Title: α5GABAA receptors regulate hippocampal sharp wave-ripple activity in vitro.

Journal: Neuropharmacology 20110301

Title: Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.

Journal: Nature 20101111

Title: Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708.

Journal: Anesthesiology 20101101

Title: alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.

Journal: Neuropharmacology 20100301

Title: Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade.

Journal: Anesthesiology 20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Effects of chronic exposure to an anabolic androgenic steroid cocktail on alpha5-receptor-mediated GABAergic transmission and neural signaling in the forebrain of female mice.

Journal: Neuroscience 20090630

Title: Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.

Journal: Neuropharmacology 20080801

Title: Differential pharmacological properties of GABAA/benzodiazepine receptor complex in dorsal compared to ventral rat hippocampus.

Journal: Neurochemistry international 20080501

Title: Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons.

Journal: Journal of neurophysiology 20071001

Title: Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20070801

Title: Diversity of GABA(A) receptor synaptic currents on individual pyramidal cortical neurons.

Journal: The European journal of neuroscience 20070201

Title: L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

Journal: Neuropharmacology 20061101

Title: The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated.

Journal: European journal of pharmacology 20061024

Title: Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20051026

Title: In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.

Journal: Neuropharmacology 20050801

Title: Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

Journal: Journal of medicinal chemistry 20040701

Title: 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

Journal: Journal of medicinal chemistry 20040325

Title: Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist.

Journal: Journal of medicinal chemistry 20031218

Title: Anxiogenic-like activity of L-655,708, a selective ligand for the benzodiazepine site of GABA(A) receptors which contain the alpha-5 subunit, in the elevated plus-maze test.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20021201

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.

Journal: Journal of neurochemistry 20010401

Title: Evaluation of native GABA(A) receptors containing an alpha 5 subunit.

Journal: European journal of pharmacology 20010209

Title: Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.

Journal: Journal of medicinal chemistry 20000113

Title: Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.

Journal: Journal of medicinal chemistry 19981008

Title: Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113(5):1061-1071.

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