Home Other Building Blocks 1305115-80-3
1305115-80-3,MFCD22665721
Catalog No.:AA01EOCH

1305115-80-3 | PF-04957325

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
1 week  
$336.00   $235.00
- +
5mg
98
1 week  
$454.00   $318.00
- +
10mg
98
1 week  
$676.00   $473.00
- +
50mg
98
1 week  
$1,760.00   $1,232.00
- +
100mg
98
1 week  
$2,332.00   $1,632.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EOCH
Chemical Name:
PF-04957325
CAS Number:
1305115-80-3
Molecular Formula:
C14H15F3N8OS
Molecular Weight:
400.3821
MDL Number:
MFCD22665721
SMILES:
Nc1nc(nc2c1nnn2C[C@@H]1OCCN(C1)Cc1nccs1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
517  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
0.5  

Literature

Title: PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex.

Journal: Cellular signalling 20171201

Title: Advances in targeting cyclic nucleotide phosphodiesterases.

Journal: Nature reviews. Drug discovery 20140401

Title: Vang AG, et al. Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Front Pharmacol. 2016 Aug 23;7:259.

Title: Dong H, et al. Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat. 2015 Jul;152(1):17-28.

Title: Tsai LC, et al. Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family. Horm Metab Res. 2012 Sep;44(10):790-4.

Title: Shimizu-Albergine M, et al. cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. Mol Pharmacol. 2012 Apr;81(4):556-66.

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Tags:1305115-80-3 Molecular Formula|1305115-80-3 MDL|1305115-80-3 SMILES|1305115-80-3 PF-04957325