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130693-82-2,MFCD00884659
Catalog No.:AA0073L4

130693-82-2 | Dorzolomide hydrochloride

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1mg
98%
in stock  
$7.00   $5.00
- +
10mg
98%
in stock  
$12.00   $8.00
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50mg
98%
in stock  
$34.00   $24.00
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100mg
98%
in stock  
$46.00   $32.00
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250mg
98%
in stock  
$82.00   $57.00
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1g
98%
in stock  
$185.00   $130.00
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5g
98%
in stock  
$571.00   $400.00
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10g
99%
in stock  
$588.00   $412.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0073L4
Chemical Name:
Dorzolomide hydrochloride
CAS Number:
130693-82-2
Molecular Formula:
C10H17ClN2O4S3
Molecular Weight:
360.9010
MDL Number:
MFCD00884659
SMILES:
CCN[C@H]1C[C@H](C)S(=O)(=O)c2c1cc(s2)S(=O)(=O)N.Cl
Properties
Computed Properties
 
Complexity:
534  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: Topical drug delivery to the eye: dorzolamide.

Journal: Acta ophthalmologica 20121101

Title: A novel and rapid validated stability-indicating UPLC method of related substances for dorzolamide hydrochloride and timolol maleate in ophthalmic dosage form.

Journal: Journal of chromatographic science 20121001

Title: In vivo imaging reveals novel aspects of retinal disease progression in Rs1h(-/Y) mice but no therapeutic effect of carbonic anhydrase inhibition.

Journal: Veterinary ophthalmology 20120901

Title: Fixed topical combinations in glaucomatous patients and ocular discomfort.

Journal: Expert opinion on pharmacotherapy 20120901

Title: Comparison of dorzolamide/timolol and latanoprost/timolol fixed combinations on diurnal intraocular pressure control in primary open-angle glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120801

Title: The effects of a fixed combination of 0.5% timolol and 1% dorzolamide on optic nerve head blood circulation.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120801

Title: Retrobulbar hemodynamics before and after oculopression with and without dorzolamide.

Journal: Current eye research 20120801

Title: Effects of ocular administration of ophthalmic 2% dorzolamide hydrochloride solution on aqueous humor flow rate and intraocular pressure in clinically normal cats.

Journal: American journal of veterinary research 20120701

Title: The clinical efficacy of a topical dorzolamide in the management of cystoid macular edema in patients with retinitis pigmentosa.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20120601

Title: Diurnal and nocturnal variations in aqueous humor dynamics of patients with ocular hypertension undergoing medical therapy.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20120601

Title: [The rabbit's IOP values after instillation of the L-arginine HCL with selected antiglaucomatic drugs mixtures prepared in vitro. (comparative study of results of the experimental works)].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20120501

Title: Topical dorzolamide for treatment of cystoid macular edema in patients with choroideremia.

Journal: Retina (Philadelphia, Pa.) 20120401

Title: Meta-analysis of α2-adrenergic agonists versus carbonic anhydrase inhibitors as adjunctive therapy.

Journal: Current medical research and opinion 20120401

Title: A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology.

Journal: Journal of enzyme inhibition and medicinal chemistry 20120201

Title: The long-term outcomes of four alternative treatment strategies for primary open-angle glaucoma.

Journal: Acta ophthalmologica 20120201

Title: Cost-effectiveness comparison between non-penetrating deep sclerectomy and maximum-tolerated medical therapy for glaucoma within the Brazilian National Health System (SUS).

Journal: Arquivos brasileiros de oftalmologia 20120101

Title: Regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model.

Journal: PloS one 20120101

Title: From dorzolamide 2%/timolol 0.5% to brinzolamide 1%/timolol 0.5% fixed combination: a 6-month, multicenter, open-label tolerability switch study.

Journal: Expert opinion on pharmacotherapy 20111101

Title: Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: implications for effects on ocular blood flow.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110901

Title: Diurnal intraocular pressure efficacy of the timolol-brimonidine fixed combination and the timolol-dorzolamide fixed combination as a first choice therapy in patients with pseudoexfoliation glaucoma.

Journal: Current eye research 20110901

Title: The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma.

Journal: Veterinary ophthalmology 20110901

Title: In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment.

Journal: International journal of pharmaceutics 20110830

Title: X-linked retinoschisis maculopathy treated with topical dorzolamide, and relationship to genotype.

Journal: Eye (London, England) 20110701

Title: Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: [Double-masked, phase III comparative study of the combination ophthalmic solution of the 1% dorzolamide hydrochloride/0.5% timolol maleate (MK-0507A) in patients with glaucoma and ocular hypertension].

Journal: Nippon Ganka Gakkai zasshi 20110601

Title: [Comparative study of the pressure lowering efficacy and variations in the ocular pulse amplitude between fixed combinations of dorzolamide/timolol and brinzolamide/timolol].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20110501

Title: A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug.

Journal: Biomedical materials (Bristol, England) 20110401

Title: [Comparison of primary medicament therapy effects and primary argon laser trabeculoplasty on regulation of intraocular pressure and stability of perimetry findings in open angle glaucoma].

Journal: Vojnosanitetski pregled 20110301

Title: Electrophysiological consequences of experimental branch retinal vein occlusion in pigs and the effect of dorzolamide.

Journal: Investigative ophthalmology & visual science 20110216

Title: The use of carbonic anhydrase inhibitors in the retreatment of cystic macular lesions in retinitis pigmentosa and X-linked retinoschisis.

Journal: Retina (Philadelphia, Pa.) 20110201

Title: Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

Journal: Acta ophthalmologica 20110201

Title: Diagnostic and therapeutic challenges.

Journal: Retina (Philadelphia, Pa.) 20110101

Title: The clinical impact of 2 different strategies for initiating therapy in patients with ocular hypertension.

Journal: Journal of glaucoma 20110101

Title: Ability of dorzolamide hydrochloride and timolol maleate to target mitochondria in glaucoma therapy.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110101

Title: Pharmacodynamic equivalence study of two preparations of eye drops containing dorzolamide and timolol in healthy volunteers.

Journal: Arzneimittel-Forschung 20110101

Title: [Assessment of visual function under treatment with topical antiglaucoma agents and systemic vasodilators. Clinical study on glaucoma patients].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20110101

Title: Efficacy of topical dorzolamide for treatment of cystic macular lesions in a patient with enhanced S-cone syndrome.

Journal: Documenta ophthalmologica. Advances in ophthalmology 20101201

Title: Development of dorzolamide hydrochloride in situ gel nanoemulsion for ocular delivery.

Journal: Drug development and industrial pharmacy 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The additive effect of dorzolamide hydrochloride (Trusopt) and a morning dose of bimatoprost (Lumigan) on intraocular pressure and retrobulbar blood flow in patients with primary open-angle glaucoma.

Journal: The British journal of ophthalmology 20101001

Title: Cyclodextrin solubilization of carbonic anhydrase inhibitor drugs: formulation of dorzolamide eye drop microparticle suspension.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101001

Title: Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma.

Journal: Current medical research and opinion 20100901

Title: Efficacy of sustained topical dorzolamide therapy for cystic macular lesions in patients with retinitis pigmentosa and usher syndrome.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20100901

Title: Predictors for visual field progression and the effects of treatment with dorzolamide 2% or brinzolamide 1% each added to timolol 0.5% in primary open-angle glaucoma.

Journal: Acta ophthalmologica 20100801

Title: Chiral separation and quantitation of dorzolamide hydrochloride enantiomers by high-performance liquid chromatography.

Journal: Journal of separation science 20100801

Title: Predictors for visual field progression.

Journal: Acta ophthalmologica 20100801

Title: Efficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide/timolol in open-angle glaucoma or ocular hypertension.

Journal: Eye (London, England) 20100701

Title: Comparison of ocular hypotensive actions of fixed combinations of brimonidine/timolol and dorzolamide/timolol.

Journal: Current medical research and opinion 20100701

Title: Topical carbonic anhydrase inhibitors and visual function in glaucoma and ocular hypertension.

Journal: Current medical research and opinion 20100601

Title: Hyaluronic acid modified chitosan nanoparticles for effective management of glaucoma: development, characterization, and evaluation.

Journal: Journal of drug targeting 20100501

Title: Retinal arteriolar vascular reactivity in untreated and progressive primary open-angle glaucoma.

Journal: Investigative ophthalmology & visual science 20100401

Title: Use of rituximab for periocular and intraocular mucosa-associated lymphoid tissue lymphoma.

Journal: Ocular immunology and inflammation 20100401

Title: Simultaneous quantification of carteolol and dorzolamide in rabbit aqueous humor and ciliary body by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100315

Title: Effect of dorzolamide and timolol on ocular pressure: blood flow relationship in patients with primary open-angle glaucoma and ocular hypertension.

Journal: Investigative ophthalmology & visual science 20100301

Title: Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy.

Journal: Acta ophthalmologica 20100201

Title: Efficacy of sustained topical dorzolamide therapy for cystic macular lesions in patients with X-linked retinoschisis.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20100201

Title: Influence of various concentrations of terpene-4-ol enhancer and carbopol-934 mucoadhesive upon the in vitro ocular transport and the in vivo intraocular pressure lowering effects of dorzolamide ophthalmic formulations using albino rabbits.

Journal: Journal of pharmaceutical sciences 20100101

Title: Skin eruption and thrombocytopaenia in a woman with glaucoma: a case report.

Journal: The West Indian medical journal 20100101

Title: Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20100101

Title: Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation.

Journal: American journal of physiology. Heart and circulatory physiology 20091201

Title: Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Fixed-combination brimonidine/timolol as adjunctive therapy to a prostaglandin analog: a 3-month, open-label, replacement study in glaucoma patients.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20091201

Title: The effects of combination glaucoma medications on ocular surface epithelial cells.

Journal: Advances in therapy 20091001

Title: Nanoemulsion as a potential ophthalmic delivery system for dorzolamide hydrochloride.

Journal: AAPS PharmSciTech 20090901

Title: Brimonidine tartrate 0.15%, dorzolamide hydrochloride 2%, and brinzolamide 1% compared as adjunctive therapy to prostaglandin analogs.

Journal: Ophthalmology 20090901

Title: Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs.

Journal: Veterinary research communications 20090901

Title: Choroidal detachment in association with topical dorzolamide: is hypotony always the cause?

Journal: Clinical & experimental ophthalmology 20090901

Title: Relationship between visual field severity and response to fixed combination dorzolamide/timolol or timolol alone.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090801

Title: Meta-analysis of medical intervention for normal tension glaucoma.

Journal: Ophthalmology 20090701

Title: Three-month, randomized, parallel-group comparison of brimonidine-timolol versus dorzolamide-timolol fixed-combination therapy.

Journal: Current medical research and opinion 20090701

Title: Corneal thickness and glaucoma medications.

Journal: Ophthalmology 20090701

Title: Relative efficacy of prostaglandins.

Journal: Ophthalmology 20090701

Title: Efficacy and safety of latanoprost in eyes with uveitic glaucoma.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090601

Title: A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5%, on retrobulbar hemodynamics and intraocular pressure in open-angle glaucoma patients.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601

Title: Effects of dorzolamide on choroidal blood flow, ciliary blood flow, and aqueous production in rabbits.

Journal: Investigative ophthalmology & visual science 20090501

Title: Short-term effect of topical dorzolamide hydrochloride on intrastromal corneal pressure in rabbit corneas in vivo.

Journal: Cornea 20090201

Title: Efficacy and tolerability of latanoprost compared to dorzolamide combined with timolol in the treatment of patients with elevated intraocular pressure: a meta-analysis of randomized, controlled trials.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090201

Title: Prolongation of activity of single intravitreal bevacizumab by adjuvant topical aqueous depressant (Timolol-Dorzolamide).

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090101

Title: The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition.

Journal: Investigative ophthalmology & visual science 20090101

Title: Relation of response to treatment with dorzolamide in X-linked retinoschisis to the mechanism of functional loss in retinoschisin.

Journal: American journal of ophthalmology 20090101

Title: The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension.

Journal: Journal of glaucoma 20090101

Title: Systematic review of intraocular pressure-lowering effects of adjunctive medications added to latanoprost.

Journal: Ophthalmic research 20090101

Title: Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma.

Journal: European journal of ophthalmology 20090101

Title: Ophthalmologist attitudes regarding fixed combination treatment for glaucoma in the European Union.

Journal: European journal of ophthalmology 20090101

Title: Visual function, optic nerve structure, and ocular blood flow parameters after 1 year of glaucoma treatment with fixed combinations.

Journal: European journal of ophthalmology 20090101

Title: The efficacy and safety of two fixed combinations: timolol-dorzolamide-brimonidine versus timolol-dorzolamide. A prospective, randomized, double-masked, multi-center, 6-month clinical trial.

Journal: Annals of ophthalmology (Skokie, Ill.) 20090101

Title: Intraocular pressure lowering, change of antiapoptotic molecule expression, and neuroretinal changes by dorzolamide 2%/timolol 0.5% combination in a chronic ocular hypertension rat model.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201

Title: A one-week comfort study of BID-dosed brinzolamide 1%/timolol 0.5% ophthalmic suspension fixed combination compared to BID-dosed dorzolamide 2%/timolol 0.5% ophthalmic solution in patients with open-angle glaucoma or ocular hypertension.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201

Title: An eight-week, multicentric, randomized, interventional, open-label, phase 4, parallel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure.

Journal: Journal of glaucoma 20081201

Title: Second-line therapy with dorzolamide/timolol or latanoprost/timolol fixed combination versus adding dorzolamide/timolol fixed combination to latanoprost monotherapy.

Journal: The British journal of ophthalmology 20081101

Title: Effects of the timolol-dorzolamide fixed combination and latanoprost on circadian diastolic ocular perfusion pressure in glaucoma.

Journal: Investigative ophthalmology & visual science 20081001

Title: The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients.

Journal: Eye (London, England) 20080901

Title: Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma.

Journal: Investigative ophthalmology & visual science 20080901

Title: Additive effect of dorzolamide hydrochloride to patients taking travoprost: a retrospective study.

Journal: Optometry (St. Louis, Mo.) 20080901

Title: A patient preference comparison of Azarga (brinzolamide/timolol fixed combination) vs Cosopt (dorzolamide/timolol fixed combination) in patients with open-angle glaucoma or ocular hypertension.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20080901

Title: A comparison of dorzolamide/timolol-fixed combination versus bimatoprost in patients with open-angle glaucoma who are poorly controlled on latanoprost.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801

Title: 24-hour control of intraocular pressure with 2% dorzolamide/0.5% timolol fixed-combination ophthalmic solution in open-angle glaucoma.

Journal: Current medical research and opinion 20080801

Title: Meta-analysis of 24-hour intraocular pressure studies evaluating the efficacy of glaucoma medicines.

Journal: Ophthalmology 20080701

Title: [Intraocular pressure after instillation of amino acid arginine and combination of two antiglaucomatics (Trusopt + Xalatane mixture) in rabbits].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20080701

Title: Success rates for switching to dorzolamide/timolol fixed combination in timolol responders who are insufficiently controlled by latanoprost monotherapy.

Journal: Acta ophthalmologica 20080601

Title: Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: a single-center, 4-year, open-label study.

Journal: Clinical therapeutics 20080601

Title: Effectiveness and safety of dorzolamide-timolol alone or combined with latanoprost in open-angle glaucoma or ocular hypertension.

Journal: The Annals of pharmacotherapy 20080401

Title: A comparative study of the effects of brinzolamide and dorzolamide on retinal oxygen saturation and ocular microcirculation in patients with primary open-angle glaucoma.

Journal: The British journal of ophthalmology 20080401

Title: [Comparative study of the effects of two anti-glaucomatous drugs on the corneal thickness in rabbits with corneal autografts].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20080401

Title: Systemic contact dermatitis to dorzolamide eye drops.

Journal: Contact dermatitis 20080301

Title: Chronic kidney disease--a disease domain complex.

Journal: Geriatrics 20080301

Title: Dorzolamide increases retinal oxygen tension after branch retinal vein occlusion.

Journal: Investigative ophthalmology & visual science 20080301

Title: Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma.

Journal: Saudi medical journal 20080301

Title: Comparison of twice-daily and three-times-daily dosing of dorzolamide in ocular hypertension and primary open-angle glaucoma patients treated with latanoprost.

Journal: Advances in therapy 20080301

Title: Carbonic anhydrases IV and IX: subcellular localization and functional role in mouse skeletal muscle.

Journal: American journal of physiology. Cell physiology 20080201

Title: Erythema multiforme after use of topical dorzolamide.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080201

Title: Intercurrent factors associated with the development of open-angle glaucoma in the European glaucoma prevention study.

Journal: American journal of ophthalmology 20080101

Title: The efficacy and harm of prostaglandin analogues for IOP reduction in glaucoma patients compared to dorzolamide and brimonidine: a systematic review.

Journal: The British journal of ophthalmology 20080101

Title: Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment.

Journal: Ophthalmology 20080101

Title: Drug modification of angiogenesis in a rat cornea model.

Journal: Investigative ophthalmology & visual science 20080101

Title: Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery.

Journal: Eye & contact lens 20080101

Title: The effect of a single dose of topical 0.005% latanoprost and 2% dorzolamide/0.5% timolol combination on the blood-aqueous barrier in dogs: a pilot study.

Journal: Veterinary ophthalmology 20080101

Title: Use of topical dorzolamide for patients with X-linked juvenile retinoschisis: case report.

Journal: Arquivos brasileiros de oftalmologia 20080101

Title: Topical antiglaucoma medications and lacrimal drainage system obstruction.

Journal: Ophthalmic plastic and reconstructive surgery 20080101

Title: Comparison of daytime efficacy and safety of dorzolamide/timolol maleate fixed combination versus latanoprost.

Journal: European journal of ophthalmology 20080101

Title: [Toxic epidermal necrolysis following dorzolamide eyedrops].

Journal: Anales de medicina interna (Madrid, Spain : 1984) 20080101

Title: A European perspective on costs and cost effectiveness of ophthalmic combinations in the treatment of open-angle glaucoma.

Journal: European journal of ophthalmology 20080101

Title: [Fixed combinations of glaucoma medications].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20080101

Title: Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.

Journal: Bioorganic & medicinal chemistry 20071201

Title: Efficacy and safety of brimonidine and dorzolamide for intraocular pressure lowering in glaucoma and ocular hypertension.

Journal: Current medical research and opinion 20071201

Title: Costs and effectiveness of travoprost versus a dorzolamide + timolol fixed combination in first-line treatment of glaucoma: analysis conducted on the United Kingdom General Practitioner Research Database.

Journal: Current medical research and opinion 20071201

Title: [Acute closed-angle glaucoma after gynecological surgery under general anesthesia].

Journal: Revista espanola de anestesiologia y reanimacion 20071101

Title: Adoption of new antiglaucoma drugs in Finland: impact of changes in copayment.

Journal: Clinical therapeutics 20071101

Title: Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination: randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens.

Journal: Journal of cataract and refractive surgery 20071001

Title: Variable involvement of the perivascular retinal tissue in carbonic anhydrase inhibitor induced relaxation of porcine retinal arterioles in vitro.

Journal: Investigative ophthalmology & visual science 20071001

Title: Effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20071001

Title: [Additive therapy with carboanhydrase inhibitors for open angle glaucoma previously treated with timolol 0.5% drops].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20070901

Title: Intercurrent factors associated with the development of open-angle glaucoma in the European glaucoma prevention study.

Journal: American journal of ophthalmology 20070801

Title: Diuretics, placebos, and the European glaucoma prevention study.

Journal: American journal of ophthalmology 20070801

Title: Ocular comfort of combination glaucoma therapies: brimonidine 0.2%/timolol 0.5% compared with dorzolamide 2%/timolol 0.5%.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801

Title: Hypotensive effect of profilin on rabbit intraocular pressure.

Journal: European journal of pharmacology 20070712

Title: Continued use of dorzolamide for the treatment of cystoid macular oedema in patients with retinitis pigmentosa.

Journal: The British journal of ophthalmology 20070601

Title: Retrobulbar haemodynamic effects of the latanoprost/timolol and the dorzolamide/timolol fixed combinations in newly diagnosed glaucoma patients.

Journal: International journal of clinical practice 20070501

Title: X-linked retinoschisis: an update.

Journal: Journal of medical genetics 20070401

Title: Acute visual loss due to serous retinal detachment from acquired optic pit may be a rare presentation of primary open-angle glaucoma.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070401

Title: Comparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressure.

Journal: Current medical research and opinion 20070401

Title: Hypotony and choroidal detachment as a complication of topical combined timolol and dorzolamide.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070401

Title: [Toxic epidermal necrolysis following eyedrop treatment for glaucoma].

Journal: Annales de dermatologie et de venereologie 20070401

Title: Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol.

Journal: British journal of clinical pharmacology 20070301

Title: Central corneal thickness in the European Glaucoma Prevention Study.

Journal: Ophthalmology 20070301

Title: Anosmia as an adverse effect of dorzolamid.

Journal: Acta ophthalmologica Scandinavica 20070301

Title: Comparison of the ocular hypotensive effects of bimatoprost and timolol-dorzolamide combination in patients with elevated intraocular pressure: a 6-month study.

Journal: Acta ophthalmologica Scandinavica 20070201

Title: Drug-induced ectropion: what is best practice?

Journal: Ophthalmology 20070201

Title: Dorzolamide hydrochloride: an antiglaucoma agent.

Journal: Acta crystallographica. Section C, Crystal structure communications 20070201

Title: [Case of pigmentary glaucoma treated with medical therapy, laser treatment, and trabeculotomy].

Journal: Nippon Ganka Gakkai zasshi 20070201

Title: Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs.

Journal: The British journal of ophthalmology 20070101

Title: Intraocular pressure-lowering effect of adding dorzolamide or latanoprost to timolol: a meta-analysis of randomized clinical trials.

Journal: Ophthalmology 20070101

Title: Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study.

Journal: Ophthalmology 20070101

Title: Circadian intraocular pressure control with dorzolamide versus timolol maleate add-on treatments in primary open-angle glaucoma patients using latanoprost.

Journal: Ophthalmic research 20070101

Title: Effects of topical dorzolamide on IOP after phacoemulsification with different types of ophthalmic viscosurgical devices.

Journal: European journal of ophthalmology 20070101

Title: Pheochromocytoma presenting with bithalamic infarction, dementia, and increased intraocular pressure.

Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20070101

Title: Corneal edema after aqueous drainage device implantation.

Journal: Journal of glaucoma 20070101

Title: Effects of topical 2% dorzolamide hydrochloride alone and in combination with 0.5% timolol maleate on intraocular pressure in normal feline eyes.

Journal: Veterinary ophthalmology 20070101

Title: [Neuroprotection in glaucoma].

Journal: Annales Academiae Medicae Stetinensis 20070101

Title: Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.

Journal: American journal of ophthalmology 20061001

Title: The additive effect of topical dorzolamide and systemic acetazolamide in pediatric glaucoma.

Journal: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20061001

Title: A comparative analysis of the effects of the fixed combination of timolol and dorzolamide versus latanoprost plus timolol on ocular hemodynamics and visual function in patients with primary open-angle glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001

Title: Use of dorzolamide for patients with X-linked retinoschisis.

Journal: Retina (Philadelphia, Pa.) 20060901

Title: Comparison of the efficacy and safety of travoprost with a fixed-combination of dorzolamide and timolol in patients with open-angle glaucoma or ocular hypertension.

Journal: Current medical research and opinion 20060901

Title: [Blurred vision after instillation of topical carbonic anhydrase inhibitor].

Journal: Nippon Ganka Gakkai zasshi 20060901

Title: Additive effect of dorzolamide or carteolol to latanoprost in primary open-angle glaucoma: a prospective randomized crossover trial.

Journal: Journal of glaucoma 20060801

Title: Optic nerve pH and PO2: the effects of carbonic anhydrase inhibition, and metabolic and respiratory acidosis.

Journal: Acta ophthalmologica Scandinavica 20060801

Title: Effects of topical hypotensive drugs on circadian IOP, blood pressure, and calculated diastolic ocular perfusion pressure in patients with glaucoma.

Journal: Investigative ophthalmology & visual science 20060701

Title: Effects of topical antiglaucoma application on conjunctival impression cytology specimens.

Journal: American journal of ophthalmology 20060701

Title: Volumetric colour Doppler imaging: a useful tool for the determination of ocular blood flow in glaucoma patients?

Journal: Eye (London, England) 20060601

Title: The effect of timolol-dorzolamide and timolol-pilocarpine combinations on ocular blood flow in patients with glaucoma.

Journal: American journal of ophthalmology 20060601

Title: Allergic contact dermatitis from timolol and dorzolamide eye drops.

Journal: Contact dermatitis 20060601

Title: The in vitro effects of some pesticides on carbonic anhydrase activity of Oncorhynchus mykiss and Cyprinus carpio carpio fish.

Journal: Journal of hazardous materials 20060520

Title: Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.

Journal: American journal of ophthalmology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060401

Title: Inhibition of apoptosis and reduction of intracellular pH decrease in retinal neural cell cultures by a blocker of carbonic anhydrase.

Journal: Investigative ophthalmology & visual science 20060301

Title: Effect of topical dorzolamide on rabbit central corneal thickness.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060201

Title: Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells.

Journal: The Kaohsiung journal of medical sciences 20060201

Title: A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients.

Journal: Current medical research and opinion 20060101

Title: Switching from dorzolamide to brinzolamide: effect on intraocular pressure and patient comfort.

Journal: Japanese journal of ophthalmology 20060101

Title: Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.

Journal: Veterinary ophthalmology 20060101

Title: [Intraocular pressure after ND: YAG laser capsulotomy in pseudophakic patients with glaucoma].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20060101

Title: Brimonidine/Timolol: a viewpoint by Francisco J. Goñi.

Journal: Drugs & aging 20060101

Title: A comparison of latanoprost monotherapy with a combination therapy of timolol/dorzolamide in patients with primary open-angle glaucoma.

Journal: Annals of ophthalmology (Skokie, Ill.) 20060101

Title: Dorzolamide and timolol saves retinal ganglion cells in glaucomatous adult rats.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

Title: Comparison of latanoprost monotherapy and combined therapy of 0.5% timolol and 1% dorzolamide in chronic primary angle-closure glaucoma (CACG) in Japanese patients.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

Title: Toxic epidermal necrolysis secondary to timolol, dorzolamide, and latanoprost eyedrops.

Journal: Journal of the American Academy of Dermatology 20051101

Title: Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension.

Journal: The British journal of ophthalmology 20051001

Title: The efficacy and ocular discomfort of substituting brinzolamide for dorzolamide in combination therapy with latanoprost, timolol, and dorzolamide.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051001

Title: Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.

Journal: Bioorganic & medicinal chemistry letters 20050901

Title: European Glaucoma Prevention Study.

Journal: Ophthalmology 20050901

Title: A randomized trial assessing dorzolamide in patients with glaucoma who are younger than 6 years.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20050901

Title: Efficacy of the dorzolamide/timolol fixed combination versus latanoprost in the treatment of ocular hypertension or glaucoma: combined analysis of pooled data from two large randomized observer and patient-masked studies.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601

Title: Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model.

Journal: The British journal of ophthalmology 20050401

Title: Topical dorzolamide increases pericentral visual function in age-related maculopathy: pilot study findings with short-wavelength automated perimetry.

Journal: Acta ophthalmologica Scandinavica 20050401

Title: 24-hour intraocular pressures with brimonidine purite versus dorzolamide added to latanoprost in primary open-angle glaucoma subjects.

Journal: Ophthalmology 20050401

Title: The efficacy and safety of topical brinzolamide and dorzolamide when added to the combination therapy of latanoprost and a beta-blocker in patients with glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050401

Title: An unusual appearance of limbal conjunctival follicles in a patient on brimonidine and dorzolamide.

Journal: Eye (London, England) 20050301

Title: Results of the European Glaucoma Prevention Study.

Journal: Ophthalmology 20050301

Title: Comparison of additional intraocular pressure-lowering effects of latanoprost vs brimonidine in primary open-angle glaucoma patients with intraocular pressure uncontrolled by timolol-dorzolamide combination.

Journal: Eye (London, England) 20050201

Title: Alphagan allergy may increase the propensity for multiple eye-drop allergy.

Journal: Eye (London, England) 20050201

Title: Comparison of the efficacy and safety of dorzolamide 2% when added to brimonidine 0.2% or timolol maleate 0.5% in patients with primary open-angle glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050201

Title: Contact dermatitis caused by allergy to dorzolamide.

Journal: Contact dermatitis 20050201

Title: Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050201

Title: Dorzolamide influences the autoregulation of major retinal vessels caused by artificial intraocular pressure elevation in patients with POAG: a clinical study.

Journal: Current eye research 20050201

Title: Cyclodextrin formulation of dorzolamide and its distribution in the eye after topical administration.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20050120

Title: Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428].

Journal: BMC ophthalmology 20050101

Title: Safety and efficacy of bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% fixed combination.

Journal: European journal of ophthalmology 20050101

Title: Effect of apraclonidine versus dorzolamide on intraocular pressure after phacoemulsification.

Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20050101

Title: Comparative analysis of the efficacy and safety of latanoprost, travoprost and the fixed combination timolol-dorzolamide; a prospective, randomized, masked, cross-over design study.

Journal: Oftalmologia (Bucharest, Romania : 1990) 20050101

Title: Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%.

Journal: Eye (London, England) 20041201

Title: A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients.

Journal: Acta ophthalmologica Scandinavica 20041201

Title: Two-year follow-up of latanoprost 0.005% monotherapy after changing from previous glaucoma therapies.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041201

Title: Influence of inorganic mobile phase additives on the retention, efficiency and peak symmetry of protonated basic compounds in reversed-phase liquid chromatography.

Journal: Journal of chromatography. A 20040917

Title: Short-term ocular tolerability of dorzolamide 2% and brinzolamide 1% vs placebo in primary open-angle glaucoma and ocular hypertension subjects.

Journal: Eye (London, England) 20040901

Title: [Impact of prostaglandin-F(2alpha)-analogues and carbonic anhydrase inhibitors on central corneal thickness -- a cross-sectional study on 403 eyes].

Journal: Klinische Monatsblatter fur Augenheilkunde 20040901

Title: Comparing the fixed combination dorzolamide-timolol (Cosopt) to concomitant administration of 2% dorzolamide (Trusopt) and 0.5% timolol -- a randomized controlled trial and a replacement study.

Journal: Journal of clinical pharmacy and therapeutics 20040801

Title: Dorzolamide-induced choroidal detachment in a surgically untreated eye.

Journal: American journal of ophthalmology 20040801

Title: Assessment of retinal hemodynamics with the Canon laser blood flowmeter after a single dose of 2% dorzolamide hydrochloride eyedrops.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20040801

Title: Brimonidine purite 0.15% versus dorzolamide 2% each given twice daily to reduce intraocular pressure in subjects with open angle glaucoma or ocular hypertension.

Journal: The British journal of ophthalmology 20040701

Title: Endothelial changes associated with topical dorzolamide do appear to be significant.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20040701

Title: Effects on aqueous flow of dorzolamide combined with either timolol or acetazolamide.

Journal: Journal of glaucoma 20040601

Title: Trends in glaucoma surgery before and after the introduction of new topical glaucoma pharmacotherapies.

Journal: Journal of glaucoma 20040601

Title: Accelerated idioventricular rhythm associated to ophthalmic timolol/dorzolamide solution.

Journal: International journal of cardiology 20040601

Title: Lichenoid drug eruption secondary to topical timolol and dorzolamide eye-drops.

Journal: The Australasian journal of dermatology 20040501

Title: Immediate postoperative use of a topical agent to prevent intraocular pressure elevation after pars plana vitrectomy with gas tamponade.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20040501

Title: Comparison of latanoprost with fixed-combination dorzolamide and timolol in adult patients with elevated intraocular pressure: an eight-week, randomized, open-label, parallel-group, multicenter study in Latin America.

Journal: Clinical therapeutics 20040501

Title: [Comparison of the effectiveness of a mixture of 10% L-arginine and HCl combined with 0.5% Timoptol and with 2% Trusopt: and the individual components on intraocular pressure in an experiment on rabbits].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20040501

Title: Dorzolamide/Timolol fixed combination versus concomitant administration of brimonidine and timolol in patients with elevated intraocular pressure: a 3-month comparison of efficacy, tolerability, and patient-reported measures.

Journal: Journal of glaucoma 20040401

Title: Comparison of the safety and efficacy of dorzolamide 2% and brimonidine 0.2% in patients with glaucoma or ocular hypertension.

Journal: Journal of glaucoma 20040401

Title: [Efficiency of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20040401

Title: [Intraocular pressure in rabbits after administration of 10% L-arginine HCl in 2% Trusopt].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20040401

Title: The effect of carbonic anhydrase inhibition on leptin secretion by rat adipose tissue.

Journal: Journal of enzyme inhibition and medicinal chemistry 20040401

Title: Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension.

Journal: Investigative ophthalmology & visual science 20040301

Title: Studies on the mechanism of action of timolol and on the effects of suppression and redirection of aqueous flow on outflow facility.

Journal: Experimental eye research 20040301

Title: Dorzolamide induces vasodilatation in isolated pre-contracted bovine retinal arteries.

Journal: Experimental eye research 20040201

Title: Optic nerve oxygen tension: the effects of timolol and dorzolamide.

Journal: The British journal of ophthalmology 20040201

Title: Aqueous humor flow in normal human eyes treated with brimonidine and dorzolamide, alone and in combination.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20040201

Title: Effects of dorzolamide hydrochloride on ocular tissues.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040201

Title: Efficacy and safety of the fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressure.

Journal: Ophthalmology 20040201

Title: [Effect of various anti-glaucoma eyedrops on human corneal epithelial cells].

Journal: Nippon Ganka Gakkai zasshi 20040201

Title: Binding affinity of bunazosin, dorzolamide, and timolol to synthetic melanin.

Journal: Japanese journal of ophthalmology 20040101

Title: Comparison of latanoprost and dorzolamide in the treatment of patients with open angle glaucoma.

Journal: Journal of Ayub Medical College, Abbottabad : JAMC 20040101

Title: [Timolol topical ophthalmic combination].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20040101

Title: [Structural and immunohistochemical changes of conjunctiva induced by topical glaucoma medication].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20040101

Title: [Neuroprotection and vasoprotection in glaucoma].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20040101

Title: [Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients].

Journal: Klinika oczna 20040101

Title: Ocular factors relevant to anti-glaucomatous eyedrop-related keratoepitheliopathy.

Journal: Journal of glaucoma 20031201

Title: Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops.

Journal: Die Pharmazie 20031201

Title: Efficacy and safety of brimonidine, dorzolamide and latanoprost as adjunctive therapy in primary open angle glaucoma.

Journal: International journal of clinical practice 20031201

Title: The efficacy and safety of dose escalation of dorzolamide used in combination with other topical antiglaucoma agents.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

Title: Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients.

Journal: Acta ophthalmologica Scandinavica 20031001

Title: A six-week, parallel, randomized, double-blind study comparing the efficacy and safety of the 0.5% timolol/2.0% MK-507 combination b.i.d. to the concomitant administration of 0.5% timolol b.i.d. and 2.0% MK-507 b.i.d.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031001

Title: Prescription of topical antiglaucoma agents for patients with contraindications to beta-blockers.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20031001

Title: Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat.

Journal: Journal of cataract and refractive surgery 20030901

Title: [Effects of ocular hypotensive agents on the circadian rhythm in intraocular pressure in rabbits as measured by telemetry].

Journal: Nippon Ganka Gakkai zasshi 20030901

Title: Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.

Journal: Bioorganic & medicinal chemistry letters 20030901

Title: Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients.

Journal: Acta ophthalmologica Scandinavica 20030801

Title: Topical dorzolamide and metabolic acidosis in a neonate.

Journal: The British journal of ophthalmology 20030801

Title: Replacing maximum-tolerated medications with latanoprost versus adding latanoprost to maximum-tolerated medications: a two-center randomized prospective trial.

Journal: Journal of glaucoma 20030801

Title: Twenty-four-hour diurnal curve comparison of commercially available latanoprost 0.005% versus the timolol and dorzolamide fixed combination.

Journal: Ophthalmology 20030701

Title: Rapid and sensitive HPLC method for the simultaneous determination of dorzolamide hydrochloride and timolol maleate in eye drops with diode-array and UV detection.

Journal: Die Pharmazie 20030701

Title: Patient persistency with pharmacotherapy in the management of glaucoma.

Journal: European journal of ophthalmology 20030701

Title: Effects of twice daily application of 2% dorzolamide on intraocular pressure in normal cats.

Journal: Veterinary ophthalmology 20030601

Title: The effects of dorzolamide on choroidal and retinal perfusion in non-exudative age related macular degeneration.

Journal: The British journal of ophthalmology 20030601

Title: The effect of topical glaucoma medications evaluated by perimetry.

Journal: The British journal of ophthalmology 20030601

Title: Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030601

Title: Unoprostone as adjunctive therapy to timolol: a double masked randomised study versus brimonidine and dorzolamide.

Journal: The British journal of ophthalmology 20030501

Title: Short-term effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20030501

Title: Acute and chronic ocular symptoms of dorzolamide 2% compared with placebo.

Journal: Journal of glaucoma 20030401

Title: Elevated intraocular pressure associated with steroid treatment for infantile spasms.

Journal: Ophthalmology 20030401

Title: The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20030401

Title: Comparison of the efficacy of the fixed-combination timolol/dorzolamide versus concomitant administration of timolol and dorzolamide.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401

Title: Switching from systemic to the topical carbonic anhydrase inhibitor dorzolamide: effect on the quality of life of glaucoma patients with drug-related side effects.

Journal: The Israel Medical Association journal : IMAJ 20030401

Title: Dorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy and tolerability.

Journal: Ophthalmology 20030301

Title: Four years later: a clinical update on latanoprost.

Journal: European journal of ophthalmology 20030301

Title: Timolol 0.5%/dorzolamide 2% fixed combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily to patients with primary open-angle glaucoma or ocular hypertension.

Journal: American journal of ophthalmology 20030201

Title: Blockers of carbonic anhydrase can cause increase of retinal capillary diameter, decrease of extracellular and increase of intracellular pH in rat retinal organ culture.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030201

Title: [Glaucoma: an ocular blood flow disorder?].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20030201

Title: Cost-minimisation study of dorzolamide versus brinzolamide in the treatment of ocular hypertension and primary open-angle glaucoma: in four European countries.

Journal: PharmacoEconomics 20030101

Title: The efficacy and safety of the timolol/dorzolamide fixed combination vs latanoprost in exfoliation glaucoma.

Journal: Eye (London, England) 20030101

Title: Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients.

Journal: European journal of ophthalmology 20030101

Title: Influence of dorzolamide on corneal endothelium.

Journal: Japanese journal of ophthalmology 20030101

Title: Experience with COSOPT, the fixed combination of timolol and dorzolamide, gained in Swiss ophthalmologists' offices.

Journal: Current medical research and opinion 20030101

Title: The free amino acids and the aqueous humor pH after antiglaucomatics in vitro.

Journal: Bratislavske lekarske listy 20030101

Title: Comparison of brimonidine/latanoprost and timolol/dorzolamide: two randomized, double-masked, parallel clinical trials.

Journal: Advances in therapy 20030101

Title: Experience with Cosopt, the fixed combination of timolol and dorzolamide, after switch from free combination of timolol and dorzolamide, in Swiss ophthalmologists' offices.

Journal: Current medical research and opinion 20030101

Title: Interventions for normal tension glaucoma.

Journal: The Cochrane database of systematic reviews 20030101

Title: Hypotony and choroidal effusion induced by topical timolol and dorzolamide in patients with previous glaucoma drainage device implantation.

Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20030101

Title: Choroidal detachment induced by dorzolamide 20 years after cataract surgery.

Journal: The British journal of ophthalmology 20021201

Title: An update on bimatoprost in glaucoma therapy.

Journal: Expert opinion on pharmacotherapy 20021201

Title: The short-term IOP-lowering effect of brimonidine 0.2% and dorzolomide 2% combination in primary open-angle glaucoma.

Journal: Acta ophthalmologica Scandinavica 20021201

Title: A comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucoma.

Journal: Acta ophthalmologica Scandinavica 20021201

Title: Primary glaucoma in Burmese cats.

Journal: Australian veterinary journal 20021101

Title: Functional analysis of retinal vessel diameter reaction to artificially raised intraocular pressure in glaucoma patients with and without dorzolamide therapy.

Journal: VASA. Zeitschrift fur Gefasskrankheiten 20021101

Title: Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide.

Journal: Investigative ophthalmology & visual science 20021001

Title: Dorzolamide X apraclonidine in the prevention of the intraocular pressure spike after Nd : YAG laser posterior capsulotomy.

Journal: Current eye research 20021001

Title: The European glaucoma prevention study design and baseline description of the participants.

Journal: Ophthalmology 20020901

Title: Reappraising first-line treatment in glaucoma management.

Journal: Hospital medicine (London, England : 1998) 20020901

Title: The effect of latanoprost on circadian intraocular pressure.

Journal: Survey of ophthalmology 20020801

Title: Latanoprost versus combined timolol and dorzolamide.

Journal: Survey of ophthalmology 20020801

Title: [Weill-Marchesani syndrome. Late athalamia following antiglaucomatous surgery].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20020701

Title: Rapid high-performance liquid chromatographic assay of dorzolamide in rabbit aqueous humor.

Journal: Biomedical chromatography : BMC 20020601

Title: Additive intraocular pressure lowering effect of various medications with latanoprost.

Journal: American journal of ophthalmology 20020601

Title: Inhibitors of NHE-1 Na+/H+ exchange reduce mouse intraocular pressure.

Journal: Investigative ophthalmology & visual science 20020601

Title: Tolerability and efficacy of dorzolamide versus acetazolamide added to timolol.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020601

Title: [Comparison of latanoprost monotherapy with timolol-dorzolamide combination in patients with open-angle glaucoma or ocular hypertension].

Journal: Journal francais d'ophtalmologie 20020601

Title: The effects of new topical treatments on management of glaucoma in Scotland: an examination of ophthalmological health care.

Journal: The British journal of ophthalmology 20020501

Title: Simultaneous determination of dorzolamide HCL and timolol maleate in eye drops by two different spectroscopic methods.

Journal: Journal of pharmaceutical and biomedical analysis 20020415

Title: Periorbital dermatitis as a side effect of topical dorzolamide.

Journal: The British journal of ophthalmology 20020401

Title: Dorzolamide and ocular blood flow in previously untreated glaucoma patients: a controlled double-masked study.

Journal: Acta ophthalmologica Scandinavica 20020401

Title: [Study on hypotensive effect of latanoprost vs timolol-dorzolamide association].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20020401

Title: Effect of Xalatan(R) and Cosopt(R) on the vascular tone of quiescent isolated pig ciliary arteries.

Journal: Klinische Monatsblatter fur Augenheilkunde 20020401

Title: Advances in topical glaucoma therapy.

Journal: Veterinary ophthalmology 20020301

Title: [Corneal descompensation in patients with endothelial compromise treated with topical dorzolamide].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20020301

Title: Application of TLC-densitometry, first-derivative UV-spectrophotometry and ratio derivative spectrophotometry for the determination of dorzolamide hydrochloride and timolol maleate.

Journal: Journal of pharmaceutical and biomedical analysis 20020201

Title: Effects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucoma.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20020101

Title: Clinical pharmacokinetics of dorzolamide.

Journal: Clinical pharmacokinetics 20020101

Title: Cutaneous drug reaction case reports: from the world literature.

Journal: American journal of clinical dermatology 20020101

Title: Topical bimatoprost: a review of its use in open-angle glaucoma and ocular hypertension.

Journal: Drugs & aging 20020101

Title: Comparison of latanoprost, brimonidine and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with primary open-angle glaucoma and ocular hypertension.

Journal: Acta ophthalmologica Scandinavica. Supplement 20020101

Title: The pulsatile ocular blood flow behaviour in open angle glaucoma patients after replacing timolol therapy with timolol and dorzolamide fixed combination: preliminary study.

Journal: Acta ophthalmologica Scandinavica. Supplement 20020101

Title: Contact dermatitis to topical drugs for glaucoma.

Journal: American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20011201

Title: Refractive change after dorzolamide use in patients with primary open-angle glaucoma and ocular hypertension.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20011201

Title: Retrobulbar blood flow in glaucoma patients with nocturnal over-dipping in systemic blood pressure.

Journal: American journal of ophthalmology 20011101

Title: Drug points. Exacerbation of angina associated with latanoprost.

Journal: BMJ (Clinical research ed.) 20011006

Title: Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma.

Journal: American journal of ophthalmology 20011001

Title: Allergic contact blepharoconjunctivitis from dorzolamide.

Journal: Contact dermatitis 20011001

Title: [Innovative glaucoma therapy. Glaucoma therapy with topical carbonic anhydrase inhibitors].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001

Title: [Prevention of early postoperative increase in intraocular pressure after phacoemulsification. Comparison of different antiglaucoma drugs].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001

Title: [The pH reaction in aqueous humor to antiglaucoma agents of various concentrations and pH levels].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20010901

Title: Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension.

Journal: American journal of ophthalmology 20010801

Title: Comparison of the additive intraocular pressure-lowering effect of latanoprost and dorzolamide when added to timolol in patients with open-angle glaucoma or ocular hypertension: a randomized, open-label, multicenter study in Greece.

Journal: Journal of glaucoma 20010801

Title: Allergic contact dermatitis due to dorzolamide eyedrops.

Journal: Contact dermatitis 20010701

Title: Treatment of intraocular pressure elevation after photorefractive keratectomy.

Journal: Journal of cataract and refractive surgery 20010701

Title: [Additive effects of topical carbonic anhydrase inhibitors].

Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20010701

Title: Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.

Journal: American journal of veterinary research 20010601

Title: [Severe hyperglycemia caused by dorzolamide].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20010601

Title: Effect of topical administration of 2% dorzlamide hydrochloride or 2% dorzlamide hydrochloride-0.5% timolol maleate on intraocular pressure in clinically normal horses.

Journal: American journal of veterinary research 20010501

Title: Intraindividual comparison of the effects of a fixed dorzolamide-timolol combination and latanoprost on intraocular pressure after small incision cataract surgery.

Journal: Journal of cataract and refractive surgery 20010501

Title: [Ocular hemodynamics and visual field in glaucoma treated with dorzolamide].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20010501

Title: Update on topical carbonic anhydrase inhibitors.

Journal: Current opinion in ophthalmology 20010401

Title: Dorzolamide-induced immune thrombocytopenia: a case report and literature review.

Journal: Journal of glaucoma 20010401

Title: Efficacy of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers in adult patients with glaucoma or ocular hypertension.

Journal: Clinical therapeutics 20010401

Title: Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs.

Journal: Veterinary ophthalmology 20010301

Title: Latanoprost versus combined therapy with timolol plus dorzolamide: IOP-lowering effect in open-angle glaucoma.

Journal: Acta ophthalmologica Scandinavica 20010201

Title: Management of glaucoma in pregnancy and lactation.

Journal: Survey of ophthalmology 20010101

Title: Comparisons of intraocular-pressure- lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

Title: Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties.

Journal: Journal of enzyme inhibition 20010101

Title: The one-month effects of topical betaxolol, dorzolamide and apraclonidine on ocular blood flow velocities in patients with newly diagnosed primary open-angle glaucoma.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

Title: [Clinical evaluation of isopropyl unoprostone (Rescula), in the adjunctive treatment of primary open angle glaucoma].

Journal: Klinika oczna 20010101

Title: Dorzolamide, a 40-year wait. From an oral to a topical carbonic anhydrase inhibitor for the treatment of glaucoma.

Journal: Pharmaceutical biotechnology 19980101

Title: Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension.

Journal: Drugs & aging 19970501

Title: J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60.

Title: Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8.

Title: Belal M Ali, et al. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1271-82.

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Tags:130693-82-2 Molecular Formula|130693-82-2 MDL|130693-82-2 SMILES|130693-82-2 Dorzolomide hydrochloride