Home Other Building Blocks 1307245-86-8
1307245-86-8,MFCD31726209
Catalog No.:AA01EGOC

1307245-86-8 | LY 2940094 - Bio-X

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$259.00   $182.00
- +
25mg
98%
in stock  
$1,022.00   $715.00
- +
50mg
98%
in stock  
$1,424.00   $997.00
- +
100mg
98%
in stock  
$2,120.00   $1,484.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EGOC
Chemical Name:
LY 2940094 - Bio-X
CAS Number:
1307245-86-8
Molecular Formula:
C22H23ClF2N4O2S
Molecular Weight:
480.9584
MDL Number:
MFCD31726209
SMILES:
OCc1cccnc1n1nc(c(c1)CN1CCC2(CC1)OCC(c1c2sc(c1)Cl)(F)F)C
Properties
Computed Properties
 
Complexity:
672  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.1  

Downstream Synthesis Route

[1]Patent:US2011/118251,2011,A1.Locationinpatent:Page/Pagecolumn41

87-69-4    1307245-86-8   
2-4-(2-chloro-4,4-difluoro-spiro5H-thieno2,3-cpyran-7,4'-piperidine-1'-yl)methyl-3-methyl-pyrazol-1-yl-3-pyridylmethanol(L)-tartrate 

[1]Patent:US2011/118251,2011,A1.Locationinpatent:Page/Pagecolumn22

[1]Patent:US2011/118251,2011,A1.Locationinpatent:Page/Pagecolumn42-43

[1]Patent:US2011/118251,2011,A1

[2]OrganicProcessResearchandDevelopment,2015,vol.19,p.1568-1575

[1]Patent:US2011/118251,2011,A1

[2]OrganicProcessResearchandDevelopment,2015,vol.19,p.1568-1575

[3]OrganicProcessResearchandDevelopment,2015,vol.19,p.1568-1575

[4]OrganicProcessResearchandDevelopment,2015,vol.19,p.1568-1575

[5]OrganicProcessResearchandDevelopment,2015,vol.19,p.1568-1575

[6]OrganicProcessResearchandDevelopment,2015,vol.19,p.1568-1575

[7]OrganicProcessResearchandDevelopment,2015,vol.19,p.1568-1575

Literature

Title: Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.

Journal: Pharmacology research & perspectives 20161201

Title: Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence.

Journal: Alcoholism, clinical and experimental research 20160901

Title: A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20160601

Title: Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.

Journal: Journal of medicinal chemistry 20140424

Title: Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.

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SDS
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