Home Other Building Blocks 130964-39-5
130964-39-5,MFCD00214120
Catalog No.:AA009CFG

130964-39-5 | H-89 DIHYDROCHLORIDE HYDRATE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
50mg
98%
in stock  
$86.00   $61.00
- +
250mg
98%
in stock  
$286.00   $200.00
- +
1g
98%
in stock  
$856.00   $600.00
- +
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA009CFG
Chemical Name:
H-89 DIHYDROCHLORIDE HYDRATE
CAS Number:
130964-39-5
Molecular Formula:
C20H22BrCl2N3O2S
Molecular Weight:
519.2826
MDL Number:
MFCD00214120
SMILES:
Brc1ccc(cc1)/C=C/CNCCNS(=O)(=O)c1cccc2c1ccnc2.Cl.Cl
Properties
Computed Properties
 
Complexity:
570  
Covalently-Bonded Unit Count:
3  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  

Literature

Title: Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhibitors of basophilic protein kinases.

Journal: Journal of medicinal chemistry 20090122

Title: Chijiwa T, et al. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N--(p-bromocinnamylamino)ethyl-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem. 1990 Mar 25;265(9):5267-72.

Title: Blazev R, et al. Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres. J Muscle Res Cell Motil. 2001;22(3):277-86.

Title: Hosseini-Zare MS, et al. Effects of BL-191 and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice. Eur J Pharmacol. 2011 Nov 30;670(2-3):464-70.

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