Home Amines 131270-08-1
131270-08-1,MFCD11615764
Catalog No.:AA000VRR

131270-08-1 | (R)-3-Amino-4-phenylbutanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
97%
in stock  
$22.00   $15.00
- +
250mg
97%
in stock  
$30.00   $21.00
- +
1g
97%
in stock  
$90.00   $63.00
- +
5g
97%
in stock  
$411.00   $288.00
- +
10g
97%
in stock  
$710.00   $497.00
- +
25g
97%
in stock  
$1,407.00   $985.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000VRR
Chemical Name:
(R)-3-Amino-4-phenylbutanoic acid
CAS Number:
131270-08-1
Molecular Formula:
C10H13NO2
Molecular Weight:
179.2157
MDL Number:
MFCD11615764
SMILES:
N[C@H](Cc1ccccc1)CC(=O)O
Properties
Computed Properties
 
Complexity:
164  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
-1.5  

Downstream Synthesis Route

[1]Gmeiner[TetrahedronLetters,1990,vol.31,#40,p.5717-5720]

[2]Gmeiner[ArchivderPharmazie,1991,vol.324,#9,p.551-557]

131270-08-1    137795-35-8   
(R)-3-(R)-5-(8-Aza-spiro4.5dec-8-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoylamino-4-phenyl-butyricacid 

[1]Makovec,Francesco;Peris,Walter;Frigerio,Sandra;Giovanetti,Roberto;Letari,Ornella;Mennuni,Laura;Revel,Laura[JournalofMedicinalChemistry,1996,vol.39,#1,p.135-142]

((S)-2-Oxo-5-phenyl-oxazolidin-4-yl)-aceticacid 
  131270-08-1 

[1]Seki,Masahiko;Matsumoto,Kazuo[TetrahedronLetters,1996,vol.37,#18,p.3165-3168]

(R)-3-Amino-4-phenyl-butyricacidmethylester;hydrochloride 
  131270-08-1 

[1]Seki,Masahiko;Matsumoto,Kazuo[Bioscience,BiotechnologyandBiochemistry,1996,vol.60,#5,p.916-917]

[1]TetrahedronAsymmetry,2007,vol.18,p.2841-2844

Literature

Title: The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.

Journal: Bioorganic & medicinal chemistry letters 20091115

Title: From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: 1,3,5-Tri- and 1,3,4,5-tetra-substituted 1,4-diazepin-2-one solid-phase synthesis.

Journal: Journal of combinatorial chemistry 20080101

Title: Analogues of arginine vasopressin and its agonist and antagonist modified in the N-terminal part of the molecule with l-beta-homophenylalanine.

Journal: The journal of peptide research : official journal of the American Peptide Society 20050401

Title: Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040920

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:131270-08-1 Molecular Formula|131270-08-1 MDL|131270-08-1 SMILES|131270-08-1 (R)-3-Amino-4-phenylbutanoic acid