Home Quinolines 131631-89-5
131631-89-5,MFCD00903893
Catalog No.:AA000ZGS

131631-89-5 | Acetamide, N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-

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5mg
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10mg
≥98%(HPLC)
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25mg
≥98%(HPLC)
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  • Technical Information
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  • Technical Information
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Technical Information
Catalog Number:
AA000ZGS
Chemical Name:
Acetamide, N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-
CAS Number:
131631-89-5
Molecular Formula:
C26H31N3O4
Molecular Weight:
449.5420
MDL Number:
MFCD00903893
SMILES:
CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2
Properties
Computed Properties
 
Complexity:
683  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
2.6  

Literature

Title: Mechanism of 1-deamino-arginine vasotocin induced natriuresis in rats.

Journal: General and comparative endocrinology 20110201

Title: Oral oxytocin antagonists.

Journal: Journal of medicinal chemistry 20100923

Title: Effects of arginine vasotocin and mesotocin on the activation and development of amiloride-blockable short-circuit current across larval, adult, and cultured larval bullfrog skins.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20100301

Title: Effects of hypertonic stimuli and arginine vasotocin (AVT) on water absorption response in Japanese treefrog, Hyla japonica.

Journal: General and comparative endocrinology 20080601

Title: Effects of arginine vasotocin and vasopressin receptor antagonists on Na+ and Cl- transport in the isolated skin of two frog species, Hyla japonica and Rana nigromaculata.

Journal: General and comparative endocrinology 20080515

Title: Oxytocin and vasopressin stimulate anion secretion by human and porcine vas deferens epithelia.

Journal: Biology of reproduction 20070901

Title: Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway.

Journal: American journal of physiology. Renal physiology 20070801

Title: Impaired arginine-vasopressin-induced aldosterone release from adrenal gland cells in mice lacking the vasopressin V1A receptor.

Journal: European journal of pharmacology 20070702

Title: Vasopressin promotes cardiomyocyte hypertrophy via the vasopressin V1A receptor in neonatal mice.

Journal: European journal of pharmacology 20070322

Title: [Renal action of vasopressin].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060201

Title: Enhanced cardiovascular alteration and Fos expression induced by central salt loading in a conscious rat transgenic for the metallothionein-vasopressin fusion gene.

Journal: Neuroscience research 20051001

Title: Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.

Journal: Archives of biochemistry and biophysics 20050615

Title: The effect of AVP-V receptor stimulation on local GFR in the rat kidney.

Journal: Acta physiologica Scandinavica 20041001

Title: Vasopressin stimulates insulin release from islet cells through V1b receptors: a combined pharmacological/knockout approach.

Journal: Molecular pharmacology 20040301

Title: Altered cardiovascular regulation in arginine vasopressin-overexpressing transgenic rat.

Journal: American journal of physiology. Endocrinology and metabolism 20031201

Title: Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus.

Journal: The European journal of neuroscience 20031201

Title: Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.

Journal: Clinical science (London, England : 1979) 20030701

Title: Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor.

Journal: Journal of medicinal chemistry 20020606

Title: N-Methylbenzanilide derivatives as a novel class of selective V(1A) receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20020121

Title: Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands.

Journal: Progress in brain research 20020101

Title: Intranephron localization and regulation of the V1a vasopressin receptor during chronic metabolic acidosis and dehydration in rats.

Journal: Pflugers Archiv : European journal of physiology 20010801

Title: Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells.

Journal: British journal of pharmacology 19981201

Title: The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.

Journal: Endocrinology 19971001

Title: Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells.

Journal: Life sciences 19950101

Title: Yamamura Y, et al. OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science. 1991 Apr 26;252(5005):572-4.

Title: Bemana I, et al. Treatment of brain edema with a nonpeptide arginine vasopressin V1 receptor antagonist OPC-21268 in rats. Neurosurgery. 1999 Jan;44(1):148-54.

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Tags:131631-89-5 Molecular Formula|131631-89-5 MDL|131631-89-5 SMILES|131631-89-5 Acetamide, N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-