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131707-25-0,MFCD00049133
Catalog No.:AA000ZJ1

131707-25-0 | Arbidol

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100g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000ZJ1
Chemical Name:
Arbidol
CAS Number:
131707-25-0
Molecular Formula:
C22H25BrN2O3S
Molecular Weight:
477.4145
MDL Number:
MFCD00049133
SMILES:
CCOC(=O)c1c(CSc2ccccc2)n(c2c1c(CN(C)C)c(O)c(c2)Br)C
Properties
Computed Properties
 
Complexity:
546  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
4.4  

Literature

Title: Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120501

Title: [The in-vitro effects of arbidol hydrochloride against 2009 new influenza virus A (H1N1)].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20120401

Title: Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20120201

Title: Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions.

Journal: Journal of medical virology 20120101

Title: Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo.

Journal: PLoS currents 20110807

Title: Steady and temporary expressions of smooth muscle actin in hair, vibrissa, arrector pili muscle, and other hair appendages of developing rats.

Journal: Acta histochemica et cytochemica 20110629

Title: In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant.

Journal: Antiviral research 20110601

Title: Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol.

Journal: PloS one 20110101

Title: Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.

Journal: PloS one 20110101

Title: [Information of the Center for Ecology and Epidemiology of Influenza, D. I. Ivanovsky Research Institute of Virology, Russian Academy of Medical Sciences, on the results of the 2009-2010 influenza and acute respiratory viral infection epidemic season (at week 40 of 2009 to week 22 of 2010) in the world and Russia].

Journal: Voprosy virusologii 20110101

Title: [Molecular characterization of pandemic influenza viruses A/H1N1(sw2009) isolated in Russia in 2009-2010].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20110101

Title: [Therapeutic efficacy of Triazavirin, a novel Russian chemotherapeutic, against influenza virus A (H5N1)].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

Title: [Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

Title: [Experience with use of immunomodulators in treatment of tonsillitis developed at the background of preimmunization by TEOVac].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

Title: High-performance liquid chromatography/tandem mass spectrometry method for the determination of arbidol in human plasma.

Journal: Journal of AOAC International 20110101

Title: Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin.

Journal: PloS one 20110101

Title: [Estimation of possible use of interferon inductors for prevention of postvaccional reactions to TEOVac in animal models].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

Title: Targeting cell entry of enveloped viruses as an antiviral strategy.

Journal: Molecules (Basel, Switzerland) 20101230

Title: Synthesis and anti-hepatitis C virus activity of novel ethyl 1H-indole-3-carboxylates in vitro.

Journal: Bioorganic & medicinal chemistry 20100815

Title: A 4-week oral toxicity study of an antiviral drug combination consisting of arbidol and acetaminophen in rats.

Journal: Drug and chemical toxicology 20100701

Title: Membranotropic effects of arbidol, a broad anti-viral molecule, on phospholipid model membranes.

Journal: The journal of physical chemistry. B 20100701

Title: A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes.

Journal: Viruses 20100501

Title: [Research progress of anti-influenza virus agents].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100301

Title: [Interferon inductor cupping of postvaccinal complications after variolation].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20100101

Title: [Study of the antiviral activity of Russian anti-influenza agents in cell culture and animal models].

Journal: Voprosy virusologii 20100101

Title: [Antiviral activity of Ingavirin in experimental lethal influenza due to influenza virus B in albino mice].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20100101

Title: [Prophylactic and therapeutic efficacies of Ingavirin, a novel Russian chemotherapeutic, with respect to influenza pathogen A (H5N1)].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20100101

Title: [Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment].

Journal: Terapevticheskii arkhiv 20100101

Title: [Triazavirin prophylactic efficacy against influenza virus A (H5N1)].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20100101

Title: [Study of Ingavirin antiviral activity against Mexican pandemic influenza virus A/H1N1/2009 in vitro and in vivo].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20100101

Title: Efficacy of arbidol on lethal hantaan virus infections in suckling mice and in vitro.

Journal: Acta pharmacologica Sinica 20090701

Title: Low pH-dependent hepatitis C virus membrane fusion depends on E2 integrity, target lipid composition, and density of virus particles.

Journal: The Journal of biological chemistry 20090626

Title: Pharmacokinetic properties and bioequivalence of two formulations of arbidol: an open-label, single-dose, randomized-sequence, two-period crossover study in healthy Chinese male volunteers.

Journal: Clinical therapeutics 20090401

Title: Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol.

Journal: Antiviral research 20090201

Title: Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo.

Journal: Archives of virology 20090101

Title: Synthetic and natural immunomodulators acting as interferon inducers.

Journal: Current pharmaceutical design 20090101

Title: [Efficacy of ingavirin in adults with influenza].

Journal: Terapevticheskii arkhiv 20090101

Title: [Toxicity estimation of unspecific medicinal antiviral agents for prophylaxis and therapy of hazard and especially hazard viral infections].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: [Viferon efficacy in influenza in adult patients].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: [The 24 May, 2009 isolation of the first A/IIV-Moscow/01/2009 (H1N1)swl strain similar to swine A(H1N1) influenza virus from the first Moscow case detected on May 21, 2009, and its deposit in the state collection of viruses (SCV No. 2452 dated May 24, 2009)].

Journal: Voprosy virusologii 20090101

Title: [Monitoring of the sensitivity of epidemic influenza virus strains isolated in Russia to etiotropic chemical agents].

Journal: Voprosy virusologii 20090101

Title: [Investigation of susceptibility of influenza viruses A (H1N1), the cause of infection in humans in April-May 2009, to antivirals in MDCK cell culture].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: [In vitro activity of Ingavirin against influenza virus A (H3N2)].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20090101

Title: Metabolite identification of arbidol in human urine by the study of CID fragmentation pathways using HPLC coupled with ion trap mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20080801

Title: [Evaluation of the efficacy of wiferon and arbidol in adult influenza].

Journal: Voprosy virusologii 20080101

Title: Arbidol: a broad-spectrum antiviral compound that blocks viral fusion.

Journal: Current medicinal chemistry 20080101

Title: [Antiviral activity of arbidol and its derivatives against the pathogen of severe acute respiratory syndrome in the cell cultures].

Journal: Voprosy virusologii 20080101

Title: [Viferon suppositories in the treatment of influenza in adults].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101

Title: [Therapeutic efficacy of Ingavirin, a new domestic formulation against influenza A virus (H3N2)].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101

Title: [Investigation of prophylactic activity of Ingavirin, a new Russian drug, against grippe A virus (H3N2)].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101

Title: Determination of arbidol in rat plasma by HPLC-UV using cloud-point extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

Title: Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol.

Journal: Biochemistry 20070522

Title: Determination of arbidol in human plasma by LC-ESI-MS.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo.

Journal: Archives of virology 20070101

Title: [Rimantadine and arbidol sensitivity of influenza viruses that caused epidemic morbidity rise in Russia in the 2004-2005 season].

Journal: Voprosy virusologii 20070101

Title: [Studying the effect of antioxidants and/or antihypoxants on cell cultures under conditions of cytotoxic action of rimantadine].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20070101

Title: [Investigation of triazavirin antiviral activity against influenza A virus (H5N1) in cell culture].

Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates.

Journal: Bioorganic & medicinal chemistry 20060215

Title: [In vitro effects of antiviral drugs on the reproduction of highly pathogenic influenza A/H5N1 virus strains that induce epizooty among poultry in the summer of 2005].

Journal: Voprosy virusologii 20060101

Title: Arbidol: a broad-spectrum antiviral that inhibits acute and chronic HCV infection.

Journal: Virology journal 20060101

Title: [Antiviral etiotropic chemicals: efficacy against influenza A viruses A subtype H5N1].

Journal: Voprosy virusologii 20060101

Title: [Sensitivity of various influenza virus strains to arbidol. Influence of arbidol combination with different antiviral drugs on reproduction of influenza virus A].

Journal: Terapevticheskii arkhiv 20050101

Title: [Sensitivity of influenza A/H5 viruses isolated from wild birds on the territory of Russia to arbidol in the cultured MDCK cells].

Journal: Voprosy virusologii 20050101

Title: [Characteristics of the immune status in specific and nonspecific prophylaxis of influenza in elderly persons].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20050101

Title: [Arbidol used in the prophylaxis of acute respiratory viral infections and their complications in servicemen].

Journal: Voenno-meditsinskii zhurnal 20040901

Title: [Efficacy and safety of arbidol in treatment of naturally acquired influenza].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20040601

Title: [Efficacy of arbidol in prophylaxis and treatment of acute respiratory viral infections in servicemen].

Journal: Voenno-meditsinskii zhurnal 20020901

Title: [Study of the effect of antiviral drugs on the reproduction of the respiratory syncytial virus by enzyme immunoassay].

Journal: Voprosy virusologii 20020101

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