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133040-77-4,MFCD00907856
Catalog No.:AA0011I1

133040-77-4 | 4(3H)-Quinazolinone, 2-[2-(5-bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-

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10mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0011I1
Chemical Name:
4(3H)-Quinazolinone, 2-[2-(5-bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-
CAS Number:
133040-77-4
Molecular Formula:
C27H24BrN3O2
Molecular Weight:
502.4024
MDL Number:
MFCD00907856
SMILES:
CC(Oc1cccc(c1)n1c(CCc2c[nH]c3c2cc(Br)cc3)nc2c(c1=O)cccc2)C
Properties
Computed Properties
 
Complexity:
728  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
5.9  

Literature

Title: Anxiogenic effect of CCK8s in the ventral hippocampus of rats: possible involvement of GABA(A) receptors.

Journal: Pharmacological reports : PR 20120101

Title: Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK(2) receptor in mice.

Journal: Peptides 20110201

Title: Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100701

Title: Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.

Journal: Peptides 20100501

Title: Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system.

Journal: Molecular psychiatry 20090301

Title: The CCK-system underpins novelty-seeking behavior in the rat: gene expression and pharmacological analyses.

Journal: Neuropeptides 20080601

Title: The CCK-system mediates adaptation to novelty-induced stress in the rat: a pharmacological evidence.

Journal: Neuroscience letters 20071120

Title: Cholecystokinin-2 receptors modulate freezing and escape behaviors evoked by the electrical stimulation of the rat dorsolateral periaqueductal gray.

Journal: Brain research 20070702

Title: Lack of interaction between NMDA and cholecystokinin-2 receptor-mediated neurotransmission in the dorsolateral periaqueductal gray in the regulation of rat defensive behaviors.

Journal: Life sciences 20061102

Title: Involvement of dorsolateral periaqueductal gray cholecystokinin-2 receptors in the regulation of a panic-related behavior in rats.

Journal: Brain research 20051012

Title: Cholecystokinin and GABA interaction in the dorsal hippocampus of rats in the elevated plus-maze test of anxiety.

Journal: Physiology & behavior 20050413

Title: Analysis of strain difference in behavior to Cholecystokinin (CCK) receptor mediated drugs in PVG hooded and Sprague-Dawley rats using elevated plus-maze test apparatus.

Journal: Neuroscience letters 20040401

Title: Genetic variations in CCK2 receptor in PVG hooded and Sprague-Dawley rats and its mRNA expression on cat exposure.

Journal: Behavioral neuroscience 20030401

Title: Strain differences in freezing behavior of PVG hooded and Sprague-Dawley rats: differential cortical expression of cholecystokinin2 receptors.

Journal: Neuroreport 20010828

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Tags:133040-77-4 Molecular Formula|133040-77-4 MDL|133040-77-4 SMILES|133040-77-4 4(3H)-Quinazolinone, 2-[2-(5-bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-