Title: Why are most phospholipidosis inducers also hERG blockers?
Journal: Archives of toxicology 20171201
Title: Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females.
Journal: Expert opinion on drug metabolism & toxicology 20121101
Title: An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.
Journal: Bioorganic & medicinal chemistry letters 20121001
Title: Identification and structural elucidation of two process impurities and stress degradants in darifenacin hydrobromide active pharmaceutical ingredient by LC-ESI/MS(n).
Journal: The Analyst 20120807
Title: Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review.
Journal: Annals of internal medicine 20120619
Title: Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats.
Journal: Urology 20120501
Title: Blood-brain barrier permeation and efflux exclusion of anticholinergics used in the treatment of overactive bladder.
Journal: Drugs & aging 20120401
Title: Interactions between cholinergic and prostaglandin signaling elements in the urothelium: role for muscarinic type 2 receptors.
Journal: Urology 20120101
Title: Neurogenic bladder.
Journal: Advances in urology 20120101
Title: Role of Cholinergic Innervation and RGS2 in Atrial Arrhythmia.
Journal: Frontiers in physiology 20120101
Title: A review and additional post-hoc analyses of the incidence and impact of constipation observed in darifenacin clinical trials.
Journal: Drug, healthcare and patient safety 20120101
Title: Contractions of the mouse prostate elicited by acetylcholine are mediated by M(3) muscarinic receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20111201
Title: Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol.
Journal: Urology 20111201
Title: Time-to-effect with darifenacin in overactive bladder: a pooled analysis.
Journal: International urogynecology journal 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers.
Journal: Neurourology and urodynamics 20111101
Title: Antimuscarinic drugs: review of the cognitive impact when used to treat overactive bladder in elderly patients.
Journal: Current urology reports 20111001
Title: Muscarinic receptors stimulate cell proliferation in the human urothelium-derived cell line UROtsa.
Journal: Pharmacological research 20111001
Title: Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex.
Journal: The Journal of pharmacology and experimental therapeutics 20111001
Title: Alternatives to potentially inappropriate medications for use in e-prescribing software: triggers and treatment algorithms.
Journal: BMJ quality & safety 20111001
Title: Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: an animal model.
Journal: Schizophrenia research 20110901
Title: Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard.
Journal: Urology 20110901
Title: α1-Adrenoceptors and muscarinic receptors in voiding function - binding characteristics of therapeutic agents in relation to the pharmacokinetics.
Journal: British journal of clinical pharmacology 20110801
Title: A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder.
Journal: British journal of clinical pharmacology 20110801
Title: The effects of jatrorrhizine on contractile responses of rat ileum.
Journal: European journal of pharmacology 20110801
Title: Design-driven LO: the discovery of new ultra long acting dibasic β2-adrenoceptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20110801
Title: 2,2-Diphenyl-acetamide.
Journal: Acta crystallographica. Section E, Structure reports online 20110801
Title: Enhanced sensitivity to afferent stimulation and impact of overactive bladder therapies in the conscious, spontaneously hypertensive rat.
Journal: The Journal of pharmacology and experimental therapeutics 20110701
Title: Systematic review and meta-analysis: do clinical trials testing antimuscarinic agents for overactive bladder adequately measure central nervous system adverse events?
Journal: Journal of the American Geriatrics Society 20110701
Title: 2,2-Diphenyl-4-(piperidin-1-yl)butanamide.
Journal: Acta crystallographica. Section E, Structure reports online 20110701
Title: Antimuscarinics suppress adenosine triphosphate and prostaglandin E2 release from urothelium with potential improvement in detrusor overactivity in rats with cerebral infarction.
Journal: The Journal of urology 20110601
Title: Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.
Journal: Bioorganic & medicinal chemistry letters 20110301
Title: Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay.
Journal: Journal of the American Geriatrics Society 20110301
Title: Patient experience with darifenacin - results of a short-term community-based survey in managing overactive bladder.
Journal: Current medical research and opinion 20110201
Title: Activation state of the M3 muscarinic acetylcholine receptor modulates mammalian odorant receptor signaling.
Journal: Science signaling 20110111
Title: Overactive bladder drugs and constipation: a meta-analysis of randomized, placebo-controlled trials.
Journal: Digestive diseases and sciences 20110101
Title: Patient satisfaction with the benefits of overactive bladder treatment: exploration of influencing factors and development of a satisfaction assessment instrument.
Journal: Neurourology and urodynamics 20110101
Title: Adverse event assessment of antimuscarinics for treating overactive bladder: a network meta-analytic approach.
Journal: PloS one 20110101
Title: An overview of the clinical use of antimuscarinics in the treatment of overactive bladder.
Journal: Advances in urology 20110101
Title: Overactive bladder: the importance of tailoring treatment to the individual patient.
Journal: Journal of multidisciplinary healthcare 20110101
Title: Comparative Evaluation of the Safety and Efficacy of Long-Term Use of Imidafenacin and Solifenacin in Patients with Overactive Bladder: A Prospective, Open, Randomized, Parallel-Group Trial (the LIST Study).
Journal: Advances in urology 20110101
Title: Tolerance of bladder antispasmodics in children with urinary incontinence: An observational study from North India.
Journal: Indian journal of pharmacology 20110101
Title: Assessment of Association of Increased Heart Rates to Cardiovascular Events among Healthy Subjects in the United States: Analysis of a Primary Care Electronic Medical Records Database.
Journal: ISRN cardiology 20110101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20101201
Title: Complex actions of neurotensin in ascending and sigmoid colonic muscle: Involvement of enteric mediators.
Journal: European journal of pharmacology 20101010
Title: Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
Journal: Urology 20101001
Title: New insights into molecular targets for urinary incontinence.
Journal: Indian journal of pharmacology 20101001
Title: The cost-effectiveness of solifenacin vs fesoterodine, oxybutynin immediate-release, propiverine, tolterodine extended-release and tolterodine immediate-release in the treatment of patients with overactive bladder in the UK National Health Service.
Journal: BJU international 20100801
Title: Do gender, age or lifestyle factors affect responses to antimuscarinic treatment in overactive bladder patients?
Journal: International journal of clinical practice 20100801
Title: Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography.
Journal: Life sciences 20100731
Title: Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100701
Title: AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder.
Journal: British journal of pharmacology 20100701
Title: Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptors.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100401
Title: Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats.
Journal: Urology 20100401
Title: Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse.
Journal: American journal of physiology. Heart and circulatory physiology 20100201
Title: The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: bladder selectivity based on in vivo drug-receptor binding characteristics of antimuscarinic agents for treatment of overactive bladder.
Journal: Journal of pharmacological sciences 20100101
Title: Functional role of cannabinoid receptors in urinary bladder.
Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20100101
Title: Pharmacological characterization of itch-associated response induced by repeated application of oxazolone in mice.
Journal: Journal of pharmacological sciences 20100101
Title: Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week, multicentre, double-blind, parallel-group trial of trospium chloride in patients with urinary urge incontinence.
Journal: BMC urology 20100101
Title: Tiotropium bromide inhibits TGF-β-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro.
Journal: International journal of chronic obstructive pulmonary disease 20100101
Title: Functional expression of muscarinic and purinoceptors in the urinary bladder of male and female rats and guinea pigs.
Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101
Title: Medical management of overactive bladder.
Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20100101
Title: New approaches in the management of multiple sclerosis.
Journal: Drug design, development and therapy 20100101
Title: Etiopathogenesis and management of bladder dysfunction in patients with posterior urethral valves.
Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20100101
Title: Bladder dysfunction in diabetes mellitus.
Journal: Frontiers in pharmacology 20100101
Title: Basic mechanisms of urgency: roles and benefits of pharmacotherapy.
Journal: World journal of urology 20091201
Title: Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20091201
Title: Treatment of dysautonomia associated with Parkinson's disease.
Journal: Parkinsonism & related disorders 20091201
Title: Anticholinergic drug use for overactive bladder in Sweden: a nationwide pharmacoepidemiological study.
Journal: International urogynecology journal and pelvic floor dysfunction 20091101
Title: Listening to the patient: a flexible approach to the use of antimuscarinic agents in overactive bladder syndrome.
Journal: BJU international 20091001
Title: Practical aspects of lifestyle modifications and behavioural interventions in the treatment of overactive bladder and urgency urinary incontinence.
Journal: International journal of clinical practice 20090801
Title: Tolterodine extended release is well tolerated in older subjects.
Journal: International journal of clinical practice 20090801
Title: Darifenacin hydro-bromide.
Journal: Acta crystallographica. Section E, Structure reports online 20090601
Title: Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 receptor single knockout mice.
Journal: British journal of pharmacology 20090401
Title: Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa.
Journal: The Journal of pharmacology and experimental therapeutics 20090301
Title: [Anticholinergic treatment of overactive bladder syndrome. Is it all the same?].
Journal: Der Urologe. Ausg. A 20090301
Title: Urodynamic measurements by radiotelemetry in conscious, freely moving beagle dogs.
Journal: The Journal of urology 20090301
Title: Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist.
Journal: European journal of pharmacology 20090301
Title: [Drug-drug interactions in urology].
Journal: Der Urologe. Ausg. A 20090301
Title: In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder.
Journal: British journal of pharmacology 20090301
Title: Psychometric validation of the overactive bladder satisfaction with treatment questionnaire (OAB-SAT-q).
Journal: Neurourology and urodynamics 20090101
Title: Muscarinic receptor antagonists for overactive bladder treatment: does one fit all?
Journal: Current opinion in urology 20090101
Title: The safety and efficacy of tolterodine extended release in the treatment of overactive bladder in the elderly.
Journal: Clinical interventions in aging 20090101
Title: Use of antimuscarinics in the elderly.
Journal: TheScientificWorldJournal 20090101
Title: A meta-analysis of the placebo response in antimuscarinic drug trials for overactive bladder.
Journal: BMC medical research methodology 20090101
Title: Resting sinus heart rate and first degree av block: modifiable risk predictors or epiphenomena?
Journal: Indian pacing and electrophysiology journal 20090101
Title: Oxybutynin extended release for the management of overactive bladder: a clinical review.
Journal: Drug design, development and therapy 20090101
Title: Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence.
Journal: BMC urology 20090101
Title: Fesoterodine for the treatment of urinary incontinence and overactive bladder.
Journal: Therapeutics and clinical risk management 20090101
Title: Behavioral intervention versus pharmacotherapy or their combinations in the management of overactive bladder dysfunction.
Journal: Advances in urology 20090101
Title: The symptomatic management of multiple sclerosis.
Journal: Annals of Indian Academy of Neurology 20090101
Title: Differential pharmacological effects of antimuscarinic drugs on heart rate: a randomized, placebo-controlled, double-blind, crossover study with tolterodine and darifenacin in healthy participants > or = 50 years.
Journal: Journal of cardiovascular pharmacology and therapeutics 20081201
Title: Gateways to clinical trials. December 2008.
Journal: Methods and findings in experimental and clinical pharmacology 20081201
Title: Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro.
Journal: International journal of chronic obstructive pulmonary disease 20081201
Title: Preserving cognitive function for patients with overactive bladder: evidence for a differential effect with darifenacin.
Journal: International journal of clinical practice 20081101
Title: Darifenacin treatment for overactive bladder in patients who expressed dissatisfaction with prior extended-release antimuscarinic therapy.
Journal: International journal of clinical practice 20081101
Title: Gateways to Clinical Trials.
Journal: Methods and findings in experimental and clinical pharmacology 20081101
Title: Human urine with solifenacin intake but not tolterodine or darifenacin intake blocks detrusor overactivity.
Journal: International urogynecology journal and pelvic floor dysfunction 20081001
Title: The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis.
Journal: European urology 20080901
Title: Choice of antimuscarinic agents for overactive bladder in the older patient: focus on darifenacin.
Journal: Clinical interventions in aging 20080901
Title: Interstitial granulomatous dermatitis associated with darifenacin.
Journal: Journal of drugs in dermatology : JDD 20080901
Title: Contribution of the M3 muscarinic receptors to the vasodilator response to acetylcholine in the human forearm vascular bed.
Journal: British journal of clinical pharmacology 20080801
Title: Similarities and differences in the autonomic control of airway and urinary bladder smooth muscle.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080801
Title: Clinical relevance of health-related quality of life outcomes with darifenacin.
Journal: BJU international 20080701
Title: Activated cholinergic signaling provides a target in squamous cell lung carcinoma.
Journal: Cancer research 20080615
Title: Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and beta-adrenoceptors.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080601
Title: In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment.
Journal: The Journal of pharmacology and experimental therapeutics 20080601
Title: Muscarinic acetylcholine receptors: new potential therapeutic targets in antinociception and in cancer therapy.
Journal: Recent patents on CNS drug discovery 20080601
Title: A journey to continence: a case study of overactive bladder syndrome.
Journal: Urologic nursing 20080601
Title: Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis.
Journal: Neuroscience letters 20080502
Title: Urgency in overactive bladder: translating experimental data into clinical practice.
Journal: Drugs of today (Barcelona, Spain : 1998) 20080501
Title: A comparison of the efficacy of darifenacin alone vs. darifenacin plus a Behavioural Modification Programme upon the symptoms of overactive bladder.
Journal: International journal of clinical practice 20080401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080301
Title: A review of solifenacin in the treatment of urinary incontinence.
Journal: Therapeutics and clinical risk management 20080201
Title: The effect of darifenacin on overactive bladders in female and male rabbits.
Journal: International urology and nephrology 20080101
Title: Pharmacological analysis of the interaction of antimuscarinic drugs at M(2) and M(3) muscarinic receptors in vivo using the pithed rat assay.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080101
Title: [Anticholinergic drugs in overactive bladder].
Journal: Gynecologie, obstetrique & fertilite 20080101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Long-term benefits of darifenacin treatment for patient quality of life: results from a 2-year extension study.
Journal: Neurourology and urodynamics 20080101
Title: Practical management of nocturia in urology.
Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20080101
Title: A novel metered dose transdermal spray formulation for oxybutynin.
Journal: Indian journal of pharmaceutical sciences 20080101
Title: Long-term darifenacin treatment for overactive bladder in patients aged 65 years and older: analysis of results from a 2-year, open-label extension study.
Journal: Current medical research and opinion 20071101
Title: Muscarinic receptor antagonists for overactive bladder.
Journal: BJU international 20071101
Title: Comparative in vivo uroselectivity profiles of anticholinergics, tested in a novel anesthetized rabbit model.
Journal: European journal of pharmacology 20071031
Title: Darifenacin treatment of patients >or= 65 years with overactive bladder: results of a randomized, controlled, 12-week trial.
Journal: Current medical research and opinion 20071001
Title: [The recommendations of the Polish Gynecologic Society regarding the use of darifenacin, selective muscarinic antagonists in the treatment of overactive bladder].
Journal: Ginekologia polska 20071001
Title: Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20070915
Title: Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve.
Journal: European urology 20070901
Title: Editorial comment on: effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve.
Journal: European urology 20070901
Title: Editorial comment on: effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve.
Journal: European urology 20070901
Title: Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3- and M2-dependent components of a motor/sensory system.
Journal: BJU international 20070901
Title: Pharmacologic management of overactive bladder.
Journal: Clinical interventions in aging 20070901
Title: Human idiopathic and neurogenic overactive bladders and the role of M2 muscarinic receptors in contraction.
Journal: European urology 20070801
Title: Overactive bladder treatments in early phase clinical trials.
Journal: Expert opinion on investigational drugs 20070701
Title: Agents for treatment of overactive bladder: a therapeutic class review.
Journal: Proceedings (Baylor University. Medical Center) 20070701
Title: Maximizing anticholinergic therapy for overactive bladder: has the ceiling been reached?
Journal: BJU international 20070601
Title: Update on drugs for overactive bladder syndrome.
Journal: Drug and therapeutics bulletin 20070601
Title: Treatment of overactive bladder: selective use of anticholinergic agents with low drug-drug interaction potential.
Journal: Geriatrics 20070501
Title: M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion.
Journal: Cancer research 20070415
Title: [Treatment of overactive bladder in elderly and old people].
Journal: Der Urologe. Ausg. A 20070401
Title: [How do medications used to treat urinary incontinence affect the cerebral function of the elderly?].
Journal: Der Urologe. Ausg. A 20070401
Title: Darifenacin: a muscarinic M3-selective receptor antagonist for the treatment of overactive bladder.
Journal: Expert opinion on pharmacotherapy 20070301
Title: Effect of antimuscarinic drugs used for overactive bladder on learning in a rat passive avoidance response test.
Journal: European journal of pharmacology 20070227
Title: Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder.
Journal: The Journal of urology 20070201
Title: M2 mediated contractions of human bladder from organ donors is associated with an increase in urothelial muscarinic receptors.
Journal: Neurourology and urodynamics 20070101
Title: Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents.
Journal: Biological & pharmaceutical bulletin 20070101
Title: Effects of imidafenacin (KRP-197/ONO-8025), a new anti-cholinergic agent, on muscarinic acetylcholine receptors. High affinities for M3 and M1 receptor subtypes and selectivity for urinary bladder over salivary gland.
Journal: Arzneimittel-Forschung 20070101
Title: Pharmacological effects of imidafenacin (KRP-197/ONO-8025), a new bladder selective anti-cholinergic agent, in rats. Comparison of effects on urinary bladder capacity and contraction, salivary secretion and performance in the Morris water maze task.
Journal: Arzneimittel-Forschung 20070101
Title: [Darifenacine--Emselex].
Journal: Journal de pharmacie de Belgique 20070101
Title: Newer agents for the management of overactive bladder.
Journal: American family physician 20061215
Title: In vivo demonstration of M3 muscarinic receptor subtype selectivity of darifenacin in mice.
Journal: Life sciences 20061214
Title: Pharmacoeconomic evaluation of antimuscarinic agents for the treatment of overactive bladder.
Journal: Pharmacotherapy 20061201
Title: New developments in the treatment of urinary incontinence.
Journal: Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20061201
Title: Treatment of overactive bladder in the aging population: focus on darifenacin.
Journal: Clinical interventions in aging 20061201
Title: Long-term treatment with darifenacin for overactive bladder: results of a 2-year, open-label extension study.
Journal: BJU international 20061101
Title: Darifenacin: Pharmacology and clinical usage.
Journal: The Urologic clinics of North America 20061101
Title: Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites?
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20061101
Title: Anticholinergic drugs versus placebo for overactive bladder syndrome in adults.
Journal: The Cochrane database of systematic reviews 20061018
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061001
Title: Differential effects of the antimuscarinic agents darifenacin and oxybutynin ER on memory in older subjects.
Journal: European urology 20060801
Title: [Anticholinergics for overactive bladder: does subtype selectivity play a role?].
Journal: Der Urologe. Ausg. A 20060701
Title: [Oral anticholinergics in overactive bladder].
Journal: Der Urologe. Ausg. A 20060701
Title: Regulation of bladder muscarinic receptor subtypes by experimental pathologies.
Journal: Autonomic & autacoid pharmacology 20060701
Title: Dose response with darifenacin, a novel once-daily M3 selective receptor antagonist for the treatment of overactive bladder: results of a fixed dose study.
Journal: International urogynecology journal and pelvic floor dysfunction 20060501
Title: The causes and consequences of overactive bladder.
Journal: Journal of women's health (2002) 20060401
Title: Practical considerations of new drugs: new choices for old problems.
Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20060401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060401
Title: Using anticholinergics to treat overactive bladder: the issue of treatment tolerability.
Journal: The American journal of medicine 20060301
Title: Pharmacologic management of overactive bladder: practical options for the primary care physician.
Journal: The American journal of medicine 20060301
Title: Management of overactive bladder and urge urinary incontinence in the elderly patient.
Journal: The American journal of medicine 20060301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060301
Title: M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder.
Journal: The Journal of pharmacology and experimental therapeutics 20060201
Title: M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder.
Journal: The Journal of pharmacology and experimental therapeutics 20060201
Title: New drugs 06, part I.
Journal: Nursing 20060201
Title: Muscarinic receptors in the bladder: from basic research to therapeutics.
Journal: British journal of pharmacology 20060201
Title: Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.
Journal: Bioorganic & medicinal chemistry letters 20060115
Title: Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
Journal: The Journal of pharmacology and experimental therapeutics 20060101
Title: Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder.
Journal: The Journal of urology 20060101
Title: Efficacy, tolerability and safety of darifenacin, an M(3) selective receptor antagonist: an investigation of warning time in patients with OAB.
Journal: International journal of clinical practice 20060101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060101
Title: The clinical pharmacokinetics of darifenacin.
Journal: Clinical pharmacokinetics 20060101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060101
Title: Public Relations: Ketchum brands new product with innovative PR strategy.
Journal: Profiles in healthcare communications 20060101
Title: Pharmacodynamic effects of darifenacin, a muscarinic M selective receptor antagonist for the treatment of overactive bladder, in healthy volunteers.
Journal: BJU international 20051101
Title: The Q-T interval and antimuscarinic drugs.
Journal: Current urology reports 20051101
Title: Darifenacin for the treatment of overactive bladder.
Journal: Women's health (London, England) 20051101
Title: Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.
Journal: Journal of medicinal chemistry 20051020
Title: Solifenacin in the management of the overactive bladder syndrome.
Journal: International journal of clinical practice 20051001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20051001
Title: Treatment of overactive bladder in the older patient: pooled analysis of three phase III studies of darifenacin, an M3 selective receptor antagonist.
Journal: European urology 20050901
Title: Role of muscarinic receptor antagonists in urgency and nocturia.
Journal: BJU international 20050901
Title: Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist (M3 SRA), compared with oxybutynin in the treatment of patients with overactive bladder.
Journal: World journal of urology 20050901
Title: QT and QTc interval with standard and supratherapeutic doses of darifenacin, a muscarinic M3 selective receptor antagonist for the treatment of overactive bladder.
Journal: Journal of clinical pharmacology 20050901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050901
Title: Solifenacin and darifenacin for overactive bladder.
Journal: Obstetrics and gynecology 20050801
Title: Comparison of darifenacin and oxybutynin in patients with overactive bladder: assessment of ambulatory urodynamics and impact on salivary flow.
Journal: European urology 20050701
Title: Darifenacin in the treatment of overactive bladder.
Journal: International journal of clinical practice 20050701
Title: Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050701
Title: Darifenacin in the treatment of overactive bladder.
Journal: Drugs of today (Barcelona, Spain : 1998) 20050701
Title: A role for muscarinic receptors or rho-kinase in hypertension associated rat bladder dysfunction?
Journal: The Journal of urology 20050601
Title: New treatment options for overactive bladder.
Journal: South Dakota journal of medicine 20050601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050601
Title: Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence.
Journal: Therapeutics and clinical risk management 20050601
Title: A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder.
Journal: BJU international 20050501
Title: Darifenacin: another antimuscarinic for overactive bladder.
Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20050501
Title: Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing.
Journal: British journal of pharmacology 20050401
Title: Increased warning time with darifenacin: a new concept in the management of urinary urgency.
Journal: The Journal of urology 20050401
Title: Solifenacin and darifenacin for overactive bladder.
Journal: The Medical letter on drugs and therapeutics 20050314
Title: An investigation of dose titration with darifenacin, an M3-selective receptor antagonist.
Journal: BJU international 20050301
Title: Assessment of cognitive function of the elderly population: effects of darifenacin.
Journal: The Journal of urology 20050201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050101
Title: New drugs: palifermin, eszopiclone, and darifenacin hydrobromide.
Journal: Journal of the American Pharmacists Association : JAPhA 20050101
Title: [Overactive bladder].
Journal: Krankenpflege Journal 20050101
Title: Improving the tolerability of anticholinergic agents in the treatment of overactive bladder.
Journal: Drug safety 20050101
Title: Contemporary and emerging drug treatments for urinary incontinence in children.
Journal: Paediatric drugs 20050101
Title: Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions.
Journal: BMC pharmacology 20050101
Title: Overactive bladder in the elderly: a guide to pharmacological management.
Journal: Drugs & aging 20050101
Title: Solifenacin in overactive bladder syndrome.
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Title: Darifenacin: a novel M3 muscarinic selective receptor antagonist for the treatment of overactive bladder.
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Title: The emerging role of solifenacin in the treatment of overactive bladder.
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Title: Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine.
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Title: Darifenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder.
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Title: Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: a Ca2+ mobilization study in monkey cells.
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Title: Muscarinic receptor subtypes in the human colon: lack of evidence for atypical subtypes.
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Title: Population pharmacokinetic modelling of darifenacin and its hydroxylated metabolite using pooled data, incorporating saturable first-pass metabolism, CYP2D6 genotype and formulation-dependent bioavailability.
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Title: Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats.
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Title: Model of rapid gastrointestinal transit in dogs: effects of muscarinic antagonists and a nitric oxide synthase inhibitor.
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Title: Irritable bowel syndrome neuropharmacology. A review of approved and investigational compounds.
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Title: Molecular and pharmacological characterization of muscarinic receptor subtypes in a rat parotid gland cell line: comparison with native parotid gland.
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Title: Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle.
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Title: Comparison of the in vitro and in vivo profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists.
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